著者

瀧井 猛将 林 大介 山本 三郎

出版者

公益社団法人 日本薬学会

雑誌

ファルマシア (ISSN:00148601)

巻号頁・発行日

vol.49, no.3, pp.206-210, 2013-03-01 (Released:2016-09-26)

著者

藤浪 得二 相模 成一郎 外山 孟生 阪口 啓一 山本 三郎 山崎 果 畑中 茂 山本 義彦 秋本 祐三

出版者

Meeting of Osaka Dermatological Association

雑誌

皮膚 (ISSN:00181390)

巻号頁・発行日

vol.4, no.3-4, pp.193-204, 1962 (Released:2010-08-25)

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The skin irritating effect of various compounds was examined and the following results were obtained.1) Alcohols and esters are, in general, non-irritating effect. Acids, lactones and phenolshave a slight irritating effect. Aldehydes are strongly irritating and halogen compounds have also a strong irritating action.2) The greater the degree of unsaturation, the stronger is the irritating effect. Double bond compounds, especially, have a strong irritating action.3) Ketones are slightly irritating but those which are readily enolized have a strong irritating action.4) The irritability of aromatic aldehydes differs according to the type and position of the substituting radical.5) Water soluble but fat insoluble and water insoluble compounds are non-irritating. Skin irritants have the property of being both water and fat soluble in a certain ratio.