著者

川村 恒夫 西村 功

出版者

農業食料工学会

雑誌

農業機械学会誌 (ISSN:02852543)

巻号頁・発行日

vol.50, no.2, pp.85-92, 1988 (Released:2010-04-30)

参考文献数

9

被引用文献数

6

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果菜類, 特にスイカの熟度や内部品質を非破壊式で測定する事を目的として打撃式の試験装置を試作し, スイカの振動特性と音響特性を測定した。ここで, 打撃による試料の振動を拘束しないよう, 単振子式の支持方法を用いて実験を行った。第1報では, 打撃式試験装置によりスイカの側面及び底面を打撃した時の振動波形及び打撃音波形の結果と, それから得られる振動・音響特性及び供試スイカの基礎物性値について報告する。第2報では, 食味検査の結果と物性値との関係, 第3報では, スイカの諸物性値と振動及び音響データの解析結果に基づく熟度又は内部品質の判定方法について報告する。

著者

花井 雄貴 松尾 和廣 横尾 卓也 大谷 真理子 西村 功史 木村 伊都紀 平山 忍 植草 秀介 草野 歩 小杉 隆祥 西澤 健司

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.41, no.1, pp.1-10, 2015-01-10 (Released:2016-01-15)

参考文献数

22

被引用文献数

2 2

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Hepatotoxicity associated with administration of voriconazole (VRCZ) is a major treatment-related adverse event and in some cases requires discontinuation of therapy. This study aimed to investigate the clinical course and risk factors for VRCZ-induced hepatotoxicity.Demographic and laboratory data were retrieved retrospectively from the medical records of 66 Japanese patients who underwent VRCZ treatment. VRCZ-induced hepatotoxicity was defined as an abnormal increase in liver function tests.VRCZ-induced hepatotoxicity was observed in 30 patients (45%), with 11 (37%) of these patients needing to discontinue the drug. Most of the events were observed within 1 to 2 weeks after the first dose of VRCZ. Of the liver function tests, an abnormal increase in γ-glutamyl transferase tended to occur earlier than changes in the other tests (ie, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and total bilirubin). Multiple logistic regression analysis showed that the trough concentration of VRCZ was a risk factor for hepatotoxicity (adjusted odds ratio = 2.89, 95%CI 1.49-5.59, P = 0.002). Based on this result, a VRCZ trough concentration < 4 μg/mL was considered to be the target for minimizing the risk of developing hepatotoxicity. After discontinuation of VRCZ in patients who developed hepatotoxicity, every liver enzyme abnormality improved within approximately 1 week.In conclusion, this study shows that VRCZ-induced hepatotoxicity may occur early after the initiation of VRCZ therapy. We therefore recommend appropriate adjustments of the starting dose and frequent liver function tests in patients treated with VRCZ, especially during the first 2 weeks.

著者

西村 功 山田 俊一 坂本 光雄 近藤 明洋 小堀 鐸二

出版者

日本建築学会

雑誌

日本建築学会構造系論文集 (ISSN:13404202)

巻号頁・発行日

vol.63, no.505, pp.61-68, 1998

被引用文献数

4 1

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Discussed in this paper is the vertical load supporting mechanism of laminated rubber bearings with hollow circular sections. The compressive stiffness of the hollow circular rubber bearings is analytically studied. Key issues discussed in this paper are 1) derivation of the governing equation that determines the compressive stiffness of the device 2) effect of bulk modulus on the compressive stiffness 3) proposition of a simple formula which is close to the rigorous solution. As a result of this analytical study, the compressive stiffness of the rubber bearings is proved to be 20 % smaller than is expected from the commonly used conventional model.

著者

西村 功

出版者

日本建築学会

雑誌

日本建築学会構造系論文集 (ISSN:13404202)

巻号頁・発行日

vol.69, no.579, pp.23-30, 2004

参考文献数

12

被引用文献数

3 8

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This paper discusses a vibration control performance of damping devices installed in a building structure. The motivation of this study comes from the recognition that we often observe much smaller damping performance than is expected from the pre-analytical study in many application projects. Emphasis is placed on the stiffness increase of the structure that is equipped with those damping devices. The relationship between the damping and stiffness augmentation is analytically obtained and expressed in a closed form solution. Therefore, the performance in terms of damping factor is easily evaluated by means of real eigen-value analysis. Numerical simulation is also conducted to ascertain the validity of the proposed method for a relatively large structure under earthquake disturbances.

著者

西村 功 植竹 富一 中村 亮一 菅野 裕一

出版者

一般社団法人日本建築学会

雑誌

学術講演梗概集. B-2, 構造II, 振動, 原子力プラント (ISSN:13414461)

巻号頁・発行日

vol.1995, pp.55-56, 1995-07-20