文献一覧: 金守良 (著者)

1 0 0 0 OA 病理組織学的なMetastatic carcinomatous cirrhosisをきたした浸潤性小葉癌の1症例

著者: 金守良金秀基小林久人奥田豊一中井敦史藤井友実早雲孝信佐々木素子狛雄一朗朝井章西川浩樹
出版者: 一般社団法人日本肝臓学会
雑誌: 肝臓 (ISSN:04514203)
巻号頁・発行日: vol.64, no.11, pp.575-582, 2023-11-01 (Released:2023-11-10)
参考文献数: 18

症例は60歳代女性.X年2月乳癌の診断のもと,左乳房切除,病理所見は浸潤性小葉癌であった.同年3月に多発リンパ節,骨転移に対して薬物療法を開始したが,8月より肝障害が出現した.薬剤性肝障害を疑い,薬物治療を中止するも肝障害は増悪した.造影CT,EOB-MRIなどの画像診断で肝転移巣は認めなかったが,腫瘍マーカーCA15-3の上昇がみられた.10月に腹部超音波カラードップラー画像・ソナゾイド造影所見から類洞閉塞などによる門脈血流低下が示唆された.経頸静脈的肝生検を施行したところ,類洞内に浸潤性小葉癌転移と肝硬変様の高度線維化を認めた.

2023-11-10 16:40:20
1 + 0 Twitter

1 0 0 0 OA NAFLD/NASH発症におけるn-3系多価不飽和脂肪酸の関与と将来展望

著者: 中本賀寿夫小畑友紀雄平澤明金啓二金守良徳山尚吾
出版者: 公益社団法人日本薬学会
雑誌: YAKUGAKU ZASSHI (ISSN:00316903)
巻号頁・発行日: vol.136, no.4, pp.583-589, 2016-04-01 (Released:2016-04-01)
参考文献数: 41
被引用文献数: 2 2

Nonalcoholic fatty liver disease (NAFLD) is characterized by the pathological accumulation of fat in the liver in the absence of any other disease related to liver steatosis, which includes a wide spectrum of liver diseases ranging from mild asymptomatic fatty liver to nonalcoholic steatohepatitis (NASH) and cirrhosis. Recently, it was reported that NAFLD is characterized by the impaired bioavailability of liver n-6 and n-3 long-chain polyunsaturated fatty acids (PUFAs). That is, compared with healthy individuals, steatosis and steatohepatitis patients have higher n-6/n-3 PUFA ratios. Furthermore, per recent research, decreasing the intake of total fats and increasing the intake of n-3 PUFAs may be beneficial in the treatment of NAFLD. In contrast, some reports describe that NASH patients have more metabolic abnormalities than NAFLD patients; however, these are not influenced by dietary fatty acids. Thus, at present, various opinions exist regarding the efficacy of n-3 PUFA in the treatment of NAFLD. In this review, we discuss the considerable interest n-3 PUFA has attracted as a potential treatment for NAFLD.