著者

原田 慎一 中本 賀寿夫 森 隆治 徳山 尚吾

出版者

一般社団法人 日本医療薬学会

雑誌

日本医療薬学会年会講演要旨集

巻号頁・発行日

vol.23, 2013

著者

相澤 風花 中本 賀寿夫 徳山 尚吾

出版者

日本疼痛学会

雑誌

PAIN RESEARCH (ISSN:09158588)

巻号頁・発行日

vol.33, no.3, pp.203-213, 2018-09-15 (Released:2018-11-06)

参考文献数

47

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It has been accepted the fact that patients with chronic pain comorbid with depression or anxiety appeal profoundly severe pain condition more than healthful emotional condition. The critical treatment of chronic pain has not been appeared although noradrenergic and serotonergic neurons were discovered as a target of treatment such as depression or anxiety. Recently, the importance of function of the n–3 free fatty acids (FFAs) such as docosahexaenoic acid (DHA) and eicosapentaenoic acid is focused on the novel target of chronic pain. However, the mechanism has not been elucidated. The G–protein coupled receptor 40 ⁄ free fatty acid receptor 1 (GPR40 ⁄ FFAR1), a receptor of middle–long chain FFAs including DHA, distribute in the brain of human and rodents. We previously reported that the GPR40 ⁄ FFAR1 suppressed not only various pain stimuli via activation of endogenous pain regulation systems but also depression–like behavior. Our previous study demonstrated that the GPR40 ⁄ FFAR1 knock–out mice show the persistent of mecha­nical allodynia after hind–paw incision. Furthermore, the GPR40 ⁄ FFAR1 knock–out mice show the abnormal emotional behaviors. Our results suggested that the GPR40 ⁄ FFAR1 has the potential of the novel therapeutic target of stress–induced chronic pain.

著者

中本 賀寿夫 小畑 友紀雄 平澤 明 金 啓二 金 守良 徳山 尚吾

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.136, no.4, pp.583-589, 2016-04-01 (Released:2016-04-01)

参考文献数

41

被引用文献数

2 2

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Nonalcoholic fatty liver disease (NAFLD) is characterized by the pathological accumulation of fat in the liver in the absence of any other disease related to liver steatosis, which includes a wide spectrum of liver diseases ranging from mild asymptomatic fatty liver to nonalcoholic steatohepatitis (NASH) and cirrhosis. Recently, it was reported that NAFLD is characterized by the impaired bioavailability of liver n-6 and n-3 long-chain polyunsaturated fatty acids (PUFAs). That is, compared with healthy individuals, steatosis and steatohepatitis patients have higher n-6/n-3 PUFA ratios. Furthermore, per recent research, decreasing the intake of total fats and increasing the intake of n-3 PUFAs may be beneficial in the treatment of NAFLD. In contrast, some reports describe that NASH patients have more metabolic abnormalities than NAFLD patients; however, these are not influenced by dietary fatty acids. Thus, at present, various opinions exist regarding the efficacy of n-3 PUFA in the treatment of NAFLD. In this review, we discuss the considerable interest n-3 PUFA has attracted as a potential treatment for NAFLD.

著者

徳山 尚吾 中本 賀寿夫

出版者

Japanese Society of Pharmaceutical Health Care and Sciences

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.39, no.9, pp.511-520, 2013-09-10 (Released:2014-09-10)

参考文献数

70

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Fatty acids are an important source of energy and an essential component of cell membranes. They also function as signal transduction molecules in a range of biological phenomena. There are several reports on the transport mechanisms of fatty acids including fatty acid transport proteins, and lipid chaperones fatty acid-binding proteins. Furthermore, fatty acids can signal through G-protein-coupled receptors or toll-like receptors.The recent westernization of dietary habits and food satiation is becoming a problem. Accordingly, the dietary intake ratio of n-3 fatty acids has dramatically decreased over several decades. Although the health influence in the change of these food habits has received little attention, in a recent study, the functional relationship between n-3 fatty acids and psychiatric disease or neurodegenerative disease has been the focus of many studies. Also, it has become apparent that the functional properties of fatty acids are modulated by factors such as the amount of individual fatty acid intake and their distribution among organs.In particular, it is reported that, in patients with depression, n-3 fatty acid contents in the brain decrease and the intake of the n-3 fatty acids can relieve psychiatric symptoms of depression. Therefore, it is thought that a fatty acid signal in the central nervous system relates to nerve activity and modulation of the synapse plasticity. However, the detailed mechanisms of these disorders have not been fully elucidated.In this mini review, we summarize a number of basic and clinical studies on n-3 fatty acids and psychiatric diseases and neurodegenerative disorders.

著者

西中 崇 中本 賀寿夫 徳山 尚吾

出版者

公益社団法人 日本薬理学会

雑誌

日本薬理学雑誌 (ISSN:00155691)

巻号頁・発行日

vol.149, no.2, pp.79-83, 2017 (Released:2017-02-01)

参考文献数

30

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幼少期に受ける精神的・身体的なストレスは,成熟期において精神疾患を含む様々な疾患の発症や重症度と強く関連する.この原因として,幼少期ストレスによる内分泌系の調節異常や神経系の機能・構造的変化を介したストレス応答性の変化,すなわちストレス脆弱性が関与することが示唆される.神経障害性疼痛のような慢性疼痛では,痛みの認知や情動に関わる脳神経系の機能変化が認められる.つまり,神経障害などの器質的異常だけでなく,精神的,心理的,社会的な要因が複雑に関与し,慢性疼痛の病態を形成している可能性が考えられる.このような痛みの慢性化に影響する精神的・社会的な要因の一つに幼少期の養育環境が挙げられる.実際に,幼少期の劣悪な養育環境によって,成人期における慢性疼痛の発症リスクが増加することが報告されており,幼少期に受けるストレスは脳内の疼痛制御機構に悪影響を及ぼすことが示唆される.しかしながら,幼少期ストレスと成熟期における慢性疼痛との関係性については明らかにされていない.最近我々は,幼少期ストレスによる慢性疼痛に対する影響を解析するための動物モデルを確立した.幼少期のストレス負荷は,成熟期における神経障害後の痛覚過敏や情動障害の増悪を引き起こす.さらに,幼少期ストレスは疼痛や情動の調節に関わる脳領域において,神経の活性化や可塑的変化の指標となるphosphorylated extracellular signal-regulated kinase(p-ERK)発現を増加させた.これらの知見は,幼少期による脳神経系の機能変化が,慢性疼痛の増悪に関与することを示唆する.本総説では,幼少期ストレスによる成熟期における脳神経系の機能変化と慢性疼痛の関係について紹介する.

著者

森本 泰子 原田 慎一 中本 賀寿夫 徳山 尚吾

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.133, no.11, pp.1243-1248, 2013 (Released:2013-11-01)

参考文献数

8

被引用文献数

1 1

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The usefulness as one of the tools for self-medication of oral rehydration therapy (ORT), recommended as a safe and effective therapy for mild to moderate dehydration, was surveyed by questionnaire for pharmacists in community pharmacies. ORT products were sold in 112 pharmacies (61%), and the common product was OS-1®. Approximately 50% of sellers answered that they had no particular difficulty in explaining ORT. Percentage to answer “hard to describe” is significantly higher in pharmacists who believe there is a need to consider underlying health conditions of customers or patients when implementing ORT. Around 77% of pharmacists considered ORT to be useful in patients as a method of self-medication. A significant number of pharmacists selling ORT products depends on the consultation from customers or patients and provide advice to them confirming that ORT was useful. From these results, it was suggested that further information concerning ORT, such as its use in patients with chronic disorders or signs for completion, and the initiative of pharmacists to participate are necessary for spread the efficacy of ORT for self-medication in patients.