1 0 0 0 OA 大都市周辺におけるメディア
1 0 0 0 副鼻腔炎とエリスロマイシン少量長期投与
- 著者
- 菊地 茂 洲崎 春海 青木 彰彦 伊藤 修 野村 恭也
- 出版者
- The Society of Practical Otolaryngology
- 雑誌
- 耳鼻咽喉科臨床 (ISSN:00326313)
- 巻号頁・発行日
- vol.84, no.1, pp.41-47, 1991
- 被引用文献数
- 41 27
Twenty six adult patients with chronic sinusitis who had undergone Caldwell-Luc operation and received conservative therapy for a long time, but still complained of nasal symptoms, were treated with 400-600mg of erythromycin (EM) per day for 7.9 months on the average.<br>1) Rhinorrhea was reduced in 60.0%, postnasal drip in 50.0%, nasal obstruction in 60.0%, hyposmia in 11.8% and sense of dullness in the head in 100%.<br>2) Rhinoscopy showed reduced mucosal swelling in 10.5%, lower volume of rhinorrhea in 80.0%, better quality of rhinorrhea in 70.0% and reduced postnasal drip in 85.7%.<br>3) This therapy was effective even when EM-resistant bacteria such as Hemophilus influenzae were present.<br>4) No significant side effects were noted in any of the patients during this therapy. Long-term low-dose EM therapy is useful in the treatment of chronic sinusitis. We consider that its effect is not due to its antibacterial activity but to some as yet unknown mechanism.