著者

Masaki TAKAHASHI Yu TAHARA

出版者

Center for Academic Publications Japan

雑誌

Journal of Nutritional Science and Vitaminology (ISSN:03014800)

巻号頁・発行日

vol.68, no.Supplement, pp.S2-S4, 2022-11-30 (Released:2022-11-25)

参考文献数

15

被引用文献数

8

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Growing evidence from animal and human research indicates the importance of homeostatic regulation of the circadian clock in the body. Dysfunction of the circadian clock caused by jet lag or night-shift work increases the risk of obesity, diabetes, cardiovascular diseases, and cancer. Thus, it is important to consider the circadian clock function for prevention of these diseases. Chrono-nutrition is a recently established research field that examines the relationship between the timing of food/nutrition and health. It is well known that breakfast skipping and late-night meals are independent risk factors for diabetes and cardiovascular diseases. Chrono-nutrition also advocates research on nutrition and the biological clock and the social implementation of the research. Breakfast can advance the phase of the peripheral clock, but late dinner can delay it. Moreover, many functional foods and nutrients, such as caffeine and polyphenols, regulate the circadian clock. In this review, we discuss how diet/nutrition entrains the peripheral clock and the relationship between meal timing and health outcomes. In addition, the effects of time-restricted feeding/eating on metabolism and related diseases are discussed. Lastly, we introduce “personalized chrono-nutrition,” that uses recent progress of technology such as sensors and the artificial intelligence/internet of things (AI/IOT) to promote personalized chrono-nutritional suggestions and health systems.

著者

Masaki Takahashi Hidekazu Kondo Keisuke Yonezu Tetsuji Shinohara Mikiko Nakagawa Naohiko Takahashi

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.8716-21, (Released:2021-11-13)

参考文献数

12

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A 54-year-old man with early repolarization syndrome (ERS) implanted with an implantable cardioverter-defibrillator (ICD) developed persistent atrial fibrillation (AF) three years after the implantation. Similarly, the remote monitoring system begun frequently detecting ventricular fibrillation (VF) and polymorphic ventricular tachycardia (PVT). Longer RR intervals were repeatedly observed just before the initiation of PVT/VF. Catheter ablation for AF successfully diminished both the PVT and VF events.

著者

Masayuki Konishi Masaki Takahashi Naoya Endo Shigeharu Numao Shun Takagi Masashi Miyashita Taishi Midorikawa Katsuhiko Suzuki Shizuo Sakamoto

出版者

一般社団法人日本体力医学会

雑誌

The Journal of Physical Fitness and Sports Medicine (ISSN:21868131)

巻号頁・発行日

vol.2, no.1, pp.121-126, 2013-03-25 (Released:2013-04-08)

参考文献数

31

被引用文献数

1 2

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The aim of this study was to investigate the effects of one night of sleep deprivation on maximal fat oxidation during a graded exercise test. Ten healthy young males underwent two 2-day control and sleep deprivation trials. Participants were allowed normal sleep from 2300 to 0700 for the control trial, whereas they were required to stay awake for 34 h during the sleep deprivation trial. At 1700 on day 2, participants performed a graded exercise test to exhaustion on a treadmill; this allowed us to determine maximal oxygen uptake and maximal fat oxidation. Before and immediately after the graded exercise test, blood samples were collected in order to measure glucose, insulin, free fatty acid, and triglyceride concentrations. Plasma glucose concentrations were significantly higher in the sleep deprivation trial than in the control trial before the graded exercise test. Serum insulin and free fatty acid concentrations were not significantly different between the two trials. Serum triglyceride concentrations were significantly lower in the sleep deprivation trial than in the control trial. The maximal fat oxidation rate, oxygen uptake, and heart rate at maximal fat oxidation intensity, during the graded exercise test, were not significantly different between the two trials. These findings suggest that maximal fat oxidation during graded exercise is unaffected by one night of sleep deprivation.

著者

Masaki Takahashi Katsuhiko Suzuki Hideki Matoba Shizuo Sakamoto Shigeru Obara

出版者

一般社団法人日本体力医学会

雑誌

The Journal of Physical Fitness and Sports Medicine (ISSN:21868131)

巻号頁・発行日

vol.1, no.1, pp.183-189, 2012-05-25 (Released:2012-08-22)

参考文献数

36

被引用文献数

2 7

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The purpose of this study was to investigate the effects of three different intensities of exercise on oxidative stress and antioxidant capacity. Eight healthy male subjects performed three different intensities of exercise for 20 minutes: (1) 70% anaerobic threshold (AT) (light intensity, LI), (2) 100% AT (moderate intensity, MI), and (3) 130% AT (high intensity, HI) on a cycle ergometer. A control (C) trial was conducted under resting conditions. Blood samples were taken pre-exercise, immediately and 30 min after exercise. In the HI trial only, the concentrations of plasma derivatives of reactive oxygen metabolites (d-ROMs) were significantly higher immediately (P<0.01) and 30 min after exercise (P<0.05) than at pre-exercise. Furthermore, plasma trolox equivalent antioxidant capacity was significantly higher immediately after exercise in the HI trial (P<0.01). And, plasma glutathione peroxidase (GPX) activity was significantly higher immediately after exercise than at pre-exercise in the MI (P<0.05) and HI trials (P<0.01). These data suggest that 20 min of pedaling exercise above the AT level may increase ROS production, while endogenous enzyme activity (especially GPX activity) or non-enzymatic antioxidants may modulate exercise-induced ROS generation. Thus, exercise under the AT level induces very little oxidative stress damage in young people.

著者

Toshiki Azuma Kentaro Sasaki Ayako Yokota Yousuke Watanabe Kazunari Kuroda Masaki Takahashi Ryousuke Asa Kyouichi Sakamoto Yusuke Ohta Toshihiro Haba Shinsuke Goto

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.35, no.6, pp.465-470, 2023 (Released:2023-06-01)

参考文献数

18

被引用文献数

1

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[Purpose] This study aimed to assess the correlation between lateral thrust and clinical symptoms after high tibial osteotomy and determine lower limb alignments that may decrease lateral thrust. [Participants and Methods] We included 54 patients (73 knees) who underwent high tibial osteotomy. Clinical symptoms, including the Japanese Orthopaedic Association score and the hip–knee–ankle angle measured via radiography, were assessed 12 months postoperatively. Lateral thrust was measured using three-dimensional motion analyses. Logistic regression was used to calculate the cut-off values with good Japanese Orthopaedic Association score and lateral thrust as dependent variables and both lateral thrust and hip–knee–ankle angle as independent variables. [Results] The lateral thrust cut-off was 3.1° (sensitivity: 0.83; specificity: 0.74; area under the curve: 0.76), while that of the hip–knee–ankle angle was 1.9° of valgus (sensitivity: 0.71; specificity: 0.81; area under the curve: 0.72). [Conclusion] Good clinical outcomes after high tibial osteotomy can be expected with a lateral thrust of ≤3.0°, indicating that the target hip–knee–ankle angle should be 2.0° valgus. In cases where valgus alignment is insufficient, lateral thrust may develop, which should be assessed using gait analysis.

著者

Toshiki Azuma Katsuya Ueno Shinsuke Goto Syunsuke Sugiki Tomo Izumoji Mototaka Kamiji Kazunari Kuroda Masaki Takahashi Ryousuke Asa Tatsuo Katsuki Toshihiro Haba

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.35, no.5, pp.373-378, 2023 (Released:2023-05-01)

参考文献数

25

被引用文献数

2

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[Purpose] This study aimed to investigate the relationship between clinical outcomes after high tibial osteotomy and metabolic syndrome-related factors, such as hypertension, dyslipidemia, diabetes mellitus, and obesity. [Participants and Methods] A total of 73 patients (73 knees) who underwent high tibial osteotomy for knee osteoarthritis between 2018 and 2020 were included. We investigated the correlation between metabolic syndrome-related factors and clinical symptom assessment (Japanese Orthopedic Association Score) and examined knee function and lower alignment. [Results] At three months postoperatively, the Japanese Orthopedic Association score showed no main and synergistic effects on metabolic syndrome-related factors, and the preoperative Japanese Orthopedic Association score only showed a main effect on metabolic syndrome-related factors. At 12 months postoperatively, the Japanese Orthopedic Association score showed main and synergistic effects on diabetes mellitus, obesity, hypertension and dislipidemia. [Conclusion] Metabolic syndrome-related factors are associated with poorer clinical outcomes after high tibial osteotomy.

著者

Masaki Takahashi Maya Yasui Tatsuo Kanamaru Mitsuhiro Nakagawa

出版者

Fuji Technology Press Ltd.

雑誌

Journal of Disaster Research (ISSN:18812473)

巻号頁・発行日

vol.17, no.6, pp.1080-1089, 2022-10-01 (Released:2022-10-01)

参考文献数

30

被引用文献数

1

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The eruptive volumes and ages of the large-scale pumice eruptions of the Asama-Maekake volcano were obtained from extensive trench-based surveys. The calibrated radiocarbon age unit (CRAU) was adopted instead of each calibrated radiocarbon age. From the high-resolution tephro-stratigraphy of large-scale pumice eruptions and CRAU dating, the eruptive history of the Asama-Maekake volcano is divided into three active and two moderately active stages as follows: active stage I (9430 to 7260 ycalBP), moderately active stage 1 (7261 to 6446 ycalBP), active stage II (6447 to 3160 ycalBP), moderately active stage 2 (3161 to 1819 ycalBP), and active stage III (1820 ycalBP to present). The eruptions of the Asama-Maekake volcano consists of small-scale (phreatic to phreato-magmatic), intermediate-scale (Vulcanian), and large-scale pumice eruptions (sub-Plinian). The active stages were characterized by the occurrence of large-scale pumice eruptions. In the moderately active stages, pumice producing eruptions were lacking but instead Vulcanian eruptions dominated. A step diagram showing the relationship between eruption volumes (DRE) and ages (CRAU) is proposed, which indicates that active stage III is not time-predictable but is volume-predictable; if the large-scale pumice eruption occurs in 2022 AD, the forecasted eruptive volume is approximately 0.21 km3. The eruption rate is not constant and changes in each stage, and the average eruption rate of active stage III (0.0011 km3/year) is larger than those of active stage I (0.00006 km3/year) and II (0.0001 km3/year).

著者

Sayaka Tomatsu Masaki Takahashi Masakazu Kakuni Gen Toshima Fumiko Kimura Junichiro Takahashi Yui Umekawa Akira Sasaki Keishi Hata

出版者

Japan Science Society of Biological Macromolecules

雑誌

Journal of Biological Macromolecules (ISSN:13472194)

巻号頁・発行日

vol.21, no.1, pp.51, 2021 (Released:2021-01-20)

参考文献数

6

著者

Keishi HATA TOMATSU Sayaka Masaki TAKAHASHI Akira SASAKI Yui UMEKAWA Kazuya MIYASHITA Kazumi OGURA Gen TOSHIMA Masahiro MAEDA Junichiro TAKAHASHI Masakazu KAKUNI

出版者

Biomedical Research Press

雑誌

Biomedical Research (ISSN:03886107)

巻号頁・発行日

vol.41, no.1, pp.33-42, 2020-02-01 (Released:2020-02-22)

参考文献数

24

被引用文献数

5

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We investigated lipid metabolism in PXB-cells, which are human primary hepatocytes isolated from liver-humanized mice, and HepG2 and HuH-7 human hepatoma cell lines. Lipoprotein levels were higher in PXB-cells than in the 2 other cell lines, and PXB-cells mainly released triglycerides and cholesterol as very low density lipoprotein (VLDL), similar to actual liver tissue, whereas the major lipoprotein released from the 2 hepatoma cell lines was LDL. RT-PCR analysis demonstrated that the gene expression levels of apolipoprotein B100 (ApoB100), the apolipoprotein of VLDL/LDL, were similar in PXB-cells and HepG2 cells, while the overexpression of ApoC2, ApoC3, and ApoE, which are components of VLDL, but not LDL, was observed in PXBcells. A protein immunoassay revealed that ApoB100 levels secreted from PXB-cells and HuH-7 cells were similar; however, ApoC3 levels were higher in PXB-cells than in the two other cell lines. We also examined the anti-lipidemic activities of fenofibrate using this assay system. Fenofibrate suppressed lipoprotein production from PXB-cells in a dose-dependent manner mainly by activating the β-oxidation pathway. These results suggest that PXB-cells produce high levels of lipoproteins and are suitable for screening anti-lipidemic agents.

著者

Shizuo Sakamoto Masayuki Konishi Hyeon Ki Kim Naoya Endoh Masaki Takahashi Syun Takagi Taishi Midorikawa

出版者

一般社団法人日本体力医学会

雑誌

The Journal of Physical Fitness and Sports Medicine (ISSN:21868131)

巻号頁・発行日

vol.1, no.3, pp.499-504, 2012-09-25 (Released:2012-10-23)

参考文献数

17

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There have been several reports on exercise prescriptions and the effects of exercise on various diseases, particularly for fat metabolism disorder. In recent years, notably from the latter half of the 1990s, studies on effective exercise prescriptions for fat metabolism disorder have taken into account the type of exercise content (type, intensity and duration per session) that has beneficial effects on fat metabolism disorder and the post-exercise recovery period. These studies have analysed the fat oxidation rate as a parameter for examining the beneficial effects of exercise on fat metabolism disorder. In this review, studies, undertaken in Japan and overseas, are introduced that are related to exercise and the fat oxidation rate.