著者

大園 享司 広瀬 大 Takashi Osono Dai Hirose

出版者

同志社大学ハリス理化学研究所

雑誌

同志社大学ハリス理化学研究報告 = The Harris science review of Doshisha University (ISSN:21895937)

巻号頁・発行日

vol.61, no.1, pp.41-51, 2020-04-30

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樹木の生葉に由来する内生菌が枯死葉からも出現しその分解に関与することが知られている。本総説では、樹木の葉リターの分解に関わる内生菌の分類と生態を集約した。内生菌の葉リターにおける出現、定着、遷移、存続と、分解プロセスへの貢献についてまとめた。環境DNAを対象とした分子生物学的手法を用いた予備的な研究から、亜熱帯林と熱帯林の樹木葉でのリグニン分解に果たす内生菌の役割は小さいことが示唆された。

著者

Kohei Watanabe Takashi Yaguchi Dai Hirose

出版者

The Japanese Society for Medical Mycology

雑誌

Medical Mycology Journal (ISSN:21856486)

巻号頁・発行日

vol.62, no.4, pp.71-78, 2021 (Released:2021-11-30)

参考文献数

37

被引用文献数

2

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Aspergillus fumigatus-related species are responsible for causing aspergillosis, which is a fatal infectious disease. Recently, there has been a series of reports of A. fumigatus-related species that are resistant to azole drugs used in clinical practice for the treatment of fungal infections. Some of these species have been isolated from outdoor environments. Testing the drug susceptibility of the strains from outdoor environments, therefore, is important. In this study, we isolated and cultured 72 strains of A. fumigatus-related species from the outdoor environment in Japan. The isolates identified via morphological observation and molecular phylogenetic analysis were Aspergillus felis, Aspergillus lentulus, Aspergillus pseudoviridinutans, Aspergillus udagawae, and Aspergillus wyomingensis. The results of the drug susceptibility testing revealed that A. felis (6 of 14 strains) and A. pseudoviridinutans (13 of 17 strains) were resistant to itraconazole (ITCZ), with 4 mg/L or higher minimum inhibitory concentrations (MICs). The voriconazole (VRCZ)-resistant strains with 4 mg/L or higher MICs were A. felis (14 of 14), A. lentulus (4 of 4), A. pseudoviridinutans (15 of 17), A. udagawae (23 of 34), A. wyomingensis (1 of 3), and A. pseudoviridinutans (1 of 3). Among them, A. felis (1 of 14) and A. pseudoviridinutans (7 of 17) demonstrated 8 mg/L or higher MICs for ITCZ and VRCZ. These results indicate that A. fumigatus-related species resistant to ITCZ and VRCZ are widely distributed in outdoor environments in Japan.