著者
Shun Yamashita Midori Tokushima Tomotaro Nakashima Naoko E Katsuki Masaki Tago Shu-ichi Yamashita
出版者
The Japanese Society of Internal Medicine
雑誌
Internal Medicine (ISSN:09182918)
巻号頁・発行日
vol.59, no.12, pp.1497-1507, 2020-06-15 (Released:2020-06-15)
参考文献数
24
被引用文献数
2

Objective No research on infective endocarditis (IE) concerning populations of more than 40 patients from all departments of the hospitals they may have visited in Japan has been conducted since 2000. The present study clarified the status quo of IE in a university hospital in Japan. Methods Data of inpatients of Saga University Hospital with definite IE from September 2007 to August 2017 were retrospectively analyzed. Patients Records of inpatients with diagnosed IE admitted to any department were scrutinized; those with "definite IE" according to the modified Duke's criteria comprised the study cohort. Results The study cohort was 74 patients with a median age 66.5 years old. Symptoms within 2 months before the first visit to our hospital included a fever (73.0%), general malaise (33.8%), disturbance of consciousness (24.3%), and dyspnea (24.3%). High-frequency causative microorganisms were Staphylococcus aureus (28.4%), followed by Streptococcus viridans (18.9%) and Enterococcus spp. (6.8%). The most frequently involved valves were the mitral valve (48.6%), followed by the aortic valve (25.7%) and multiple valves (14.9%). Patients without cardiac murmurs accounted for 37.8%, and those without or with only mild valvular disease accounted for 32.4%. The incidence of complications was 93.2%, and high-frequency complications were central nervous system disorder (60.8%), followed by glomerulonephritis (45.9%) and extracranial embolism (36.5%). Conclusion The incidences of IE without cardiac murmurs and IE without or with only minor valvular disease were higher than those values previously reported in 2000 in Japan. When IE is suspected clinically, clinicians must check thoroughly for common complications, even in patients without cardiac murmurs or valvular disease.
著者
友沢 稔 高田 雅介 John ACOCELLA E. Bruce WATSON 高森 剛
出版者
公益社団法人 日本セラミックス協会
雑誌
窯業協會誌 (ISSN:00090255)
巻号頁・発行日
vol.91, no.1056, pp.377-383, 1983-08-01 (Released:2010-04-30)
参考文献数
31
被引用文献数
7 9

約8wt%までの水を含むNa2O・3SiO2ガラスを高温高圧下で合成し, そのガラス転移点 (Tg) をDTA法により測定した. ガラス中の水はTgより高温で発泡を伴って溶離した. ガラス転移点と発泡温度はともに含水量の増加につれて減少した. 含水量の変化に対するガラス転移点の変化を高分子の可塑剤に対する種々の方程式と比較し, OHと分子状H2Oの両方の寄与を考慮に入れた方程式により, 最もよく記述されることを見出した. OHはTgを急激に下げ, 一方分子状H2Oは単にガラスを薄める効果によりわずかにTgを下げることが結論付けられた.
著者
Koichi HARAGUCHI Mineshi SAKAMOTO Akito MATSUYAMA Megumi YAMAMOTO Dang T. HUNG Hiromitsu NAGASAKA Keisuke UCHIDA Yasunori ITO Hitoshi KODAMATANI Milena HORVAT Hing M. CHAN Matthew RAND Ciprian M. CIRTIU Byoung-Gwon KIM Flemming NIELSEN Akane YAMAKAWA Nikolay MASHYANOV Nikolai PANICHEV Elena PANOVA Tomoaki WATANABE Naoki KANEKO Jun YOSHINAGA Ranny F. HERWATI Alfrida E. SUOTH Hirokatsu AKAGI
出版者
The Japan Society for Analytical Chemistry
雑誌
Analytical Sciences (ISSN:09106340)
巻号頁・発行日
vol.36, no.5, pp.561-567, 2020-05-10 (Released:2020-05-10)
参考文献数
28
被引用文献数
5

A certified reference material, NIMD-01, was developed for the analysis of mercury speciation in human hair. We collected the hair of Vietnamese males from a barbershop in Hanoi in 2016 and prepared 1200 bottles containing 3 g of sieved and blended hair powder. The certified value was given on a dry-mass basis, with the moisture content obtained by drying at 85°C for 4 h. Certified values with the expanded uncertainties (coverage factor, k = 2) were as follows: methylmercury, 0.634 ± 0.071 mg kg−1 as mercury; total mercury, 0.794 ± 0.050 mg kg−1; copper, 12.8 ± 1.4 mg kg−1; zinc, 234 ± 29 mg kg−1; selenium, 1.52 ± 0.29 mg kg−1. An indicative arsenic concentration of 0.17 ± 0.03 mg kg−1 was measured. Extended uncertainties were estimated by sample homogeneity, long- and short-term stabilities, and a characterization from measurements made by collaborating laboratories.
著者
Junkichi Kanda Megumi Furukawa Nobuo Izumo Taketoshi Shimakura Noriaki Yamamoto Hideaki E. Takahashi Hiroyuki Wakabayashi
出版者
International Research and Cooperation Association for Bio & Socio-Sciences Advancement
雑誌
Drug Discoveries & Therapeutics (ISSN:18817831)
巻号頁・発行日
vol.14, no.2, pp.77-83, 2020-04-30 (Released:2020-05-06)
参考文献数
39

Tacrolimus, a calcineurin inhibitor, affects bone metabolism and increases the risk of fracture due to marked bone loss. Bisphosphonates increase the bone mineral density (BMD) in osteoporosis patients. Menatetrenone has less positive effects on BMD but reduces the risk of fracture by improving bone quality. In this study, we investigated the effectiveness of the combined administration of risedronate and menatetrenone against bone loss induced by tacrolimus. Wistar rats were divided into four groups: [1] control, [2] tacrolimus at 1.5 mg/kg, [3] tacrolimus + risedronate at 1.0 mg/kg, and [4] tacrolimus + risedronate + menatetrenone at 20 mg/kg. After the drugs were administered for 4 weeks, bone histomorphometric analysis was performed and bone strength was evaluated using a three point bending method. BMD was measured using quantitative computed tomography. Tacrolimus significantly reduced the BMD and strength properties of the lower limb bones. These tacrolimusinduced decreases were suppressed by risedronate treatment. The combined administration of risedronate and menatetrenone more significantly improved bone strength properties than risedronate alone. Bone histomorphometric analysis revealed a significant increase in bone resorption with tacrolimus. Risedronate alone significantly suppressed the tacrolimus-induced increase in bone resorption but simultaneously reduced bone formation. On the other hand, the combined administration of risedronate and menatetrenone suppressed the tacrolimus-induced increase in bone resorption, in addition to the significant risedronate-induced decrease in bone formation. This study suggests that the combined administration of risedronate and menatetrenone improves bone strength in tacrolimus-treated rats by preventing and ameliorating the risedronate-induced suppression of bone formation.
著者
HARDY D. E.
雑誌
Pacific Insects
巻号頁・発行日
vol.2, pp.383-449, 1960
被引用文献数
1