著者

Tsutsumi Naotaka Kimura Takeshi Arita Kyohei Ariyoshi Mariko Ohnishi Hidenori Yamamoto Takahiro Zuo Xiaobing Maenaka Katsumi Park Enoch Y Kondo Naomi Shirakawa Masahiro Tochio Hidehito Kato Zenichiro

出版者

Nature Publishing Group

雑誌

Nature communications (ISSN:20411723)

巻号頁・発行日

vol.5, 2014-12-15

被引用文献数

92

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免疫・神経難治疾患の治療薬開発を促進するインターロイキン18複合体立体構造を解明. 京都大学プレスリリース. 2014-12-16.

著者

中川 靖章 錦見 俊雄 桑原 宏一郎 岡 昌吾 木下 秀之 中尾 一泰 趙 晃済 稲住 英明 加藤 貴雄 中尾 一和 木村 剛 Nishida Motohiro Kato Takao Fukushima Hiroyuki Yamashita Jun K. Wijnen Wino J. Creemers Esther E. Kangawa Kenji Minamino Naoto Nakao Kazuwa Kimura Takeshi

出版者

Wiley Blackwell

雑誌

Journal of the American Heart Association (ISSN:20479980)

巻号頁・発行日

vol.6, no.2, 2017-02

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Background-Recent studies have shown that plasma levels of the biologically inactive prohormone for brain natriuretic peptide (proBNP) are increased in patients with heart failure. This can contribute to a reduction in the effectiveness of circulating BNP and exacerbate heart failure progression. The precise mechanisms governing the increase in proBNP remain unclear, however. Methods and Results-We used our recently developed, highly sensitive human proBNP assay system to investigate the mechanisms underlying the increase in plasma proBNP levels. We divided 53 consecutive patients hospitalized with heart failure into 2 groups based on their aortic plasma levels of immunoreactive BNP. Patients with higher levels exhibited more severe heart failure, a higher proportion of proBNP among the immunoreactive BNP forms secreted from failing hearts, and a weaker effect of BNP as estimated from the ratio of plasma cyclic guanosine monophosphate levels to log-transformed plasma BNP levels. Glycosylation at threonines 48 and 71 of human proBNP contributed to the increased secretion of proBNP by attenuating its processing, and GalNAc-transferase (GALNT) 1 and 2 mediated the glycosylation-regulated increase in cardiac human proBNP secretion. Cardiac GALNT1 and 2 expression was suppressed by microRNA (miR)-30, which is abundantly expressed in the myocardium of healthy hearts, but is suppressed in failing hearts. Conclusions-We have elucidated a novel miR-30-GALNT1/2 axis whose dysregulation increases the proportion of inactive proBNP secreted by the heart and impairs the compensatory actions of BNP during the progression of heart failure.

著者

青木 良尚 浜本 滋 神田 宏 佐藤 衛 木村 毅 西島 寛典 Aoki Yoshihisa Hamamoto Shigeru Kanda Hiroshi Sato Mamoru Kimura Takeshi Nishijima Hironori

出版者

宇宙航空研究開発機構(JAXA)

雑誌

宇宙航空研究開発機構特別資料: 第86-第90回風洞研究会議論文集 = JAXA Special Publication: Proceedings of the Wind Tunnel Technology Association 86th-90th meeting (ISSN:1349113X)

巻号頁・発行日

vol.JAXA-SP-14-011, pp.1-6, 2015-03-25

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第86回風洞研究会議 (2011年5月19日-20日)

著者

木村 武史 KIMURA Takeshi

出版者

筑波大学人文社会科学研究科 国際地域研究専攻

雑誌

筑波大学地域研究 (ISSN:09121412)

巻号頁・発行日

no.39, pp.39-56, 2018

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This paper attempts to examine the symbolic representation of Windigo, the cannibal monster, feared by the Algonquian people such as the Anishinabe and the Cree in the Northeastern North America. The first section introduces the topic. The second section, mainly based upon recent scholarly work by S. Smallman, reviews a history of the scholarly works on Windigo and presents the perspective to be taken for this paper. In the third section, it examines the historical changes of the Windigo images. As the historical phenomenon, the so-called Windigo Psychosis ceased to be reported by the end of the 19th century. The image of Windigo continues to be referred to by both the native people and the American-Canadian people. While this paper recognizes the contemporary native representation of Windigo as a proof of cultural creativity, it also sees historical changes in the religious perception of the image of Windigo with the recognition of etymological resemblance between the indigenous terms of owl and Windigo. In the fourth section, while admitting the importance of the moral interpretation of Windigo narrative, this paper tries to read the bodily experiential dimension as the location of religious fear of Windigo. Paying a special attention to the shamanistic narrative of Windigo, this paper attempts to read the religious meaning of personal transformation induced by the spiritual possession by Windigo.

著者

Horie Takahiro Nishino Tomohiro Baba Osamu Kuwabara Yasuhide Nakao Tetsushi Nishiga Masataka Usami Shunsuke Izuhara Masayasu Nakazeki Fumiko Ide Yuya Koyama Satoshi Sowa Naoya Yahagi Naoya Shimano Hitoshi Nakamura Tomoyuki Hasegawa Koji Kume Noriaki Yokode Masayuki Kita Toru Kimura Takeshi Ono Koh

出版者

Nature Publishing Group

雑誌

Scientific reports (ISSN:20452322)

巻号頁・発行日

vol.4, 2014-06-16

被引用文献数

44

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マウスへのマイクロRNA-33bの導入に成功 -ヒトでのHDL-コレステロールの質の改善に期待-. 京都大学プレスリリース. 2014-06-17.

著者

Hiraoka Yoshinori Matsuoka Tatsuhiko Ohno Mikiko Nakamura Kazuhiro Saijo Sayaka Matsumura Shigenobu Nishi Kiyoto Sakamoto Jiro Chen Po-Min Inoue Kazuo Fushiki Tohru Kita Toru Kimura Takeshi Nishi Eiichiro

出版者

Nature Publishing Group

雑誌

Nature communications (ISSN:20411723)

巻号頁・発行日

vol.5, 2014-02-04

被引用文献数

33

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「体温恒常性維持のメカニズムの解明」に成功. 京都大学プレスリリース. 2014-02-04.

著者

Kimura Takeshi Geya Yuto Terada Yasuhiko Kose Katsumi Haishi Tomoyuki Gemma Hiroshi Sekozawa Yoshihiko

出版者

American Institute of Physics

雑誌

Review of scientific instruments (ISSN:00346748)

巻号頁・発行日

vol.82, no.5, pp.053704, 2011-05

被引用文献数

48 12

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By combining a 0.3 T permanent magnet with flexible rotation and translation mechanism, a probe with a local electromagnetic shielding, several electrical units, a mobile lift, and an electric wagon, a mobile magnetic resonance imaging (MRI) system was developed for outdoor tree measurements. 2D cross-sectional images of normal and diseased branches of a pear tree were acquired for measurements of T1, T2, proton density, and apparent diffusion constant (ADC). The ADC map clearly differentiated diseased from normal branches. A whole-day measurement of the ADC map demonstrated that microscopic water flow in the normal branch changed proportionally with solar radiation. Therefore, we have concluded that our mobile MRI system is a powerful tool for studies of plants in outdoor environments.