著者

黒田 誠 MAKOTO KURODA

出版者

和洋女子大学

雑誌

和洋女子大学紀要 = The journal of Wayo Women's University (ISSN:18846351)

巻号頁・発行日

vol.50, pp.201-216, 2010-03

著者

黒田 誠 MAKOTO KURODA

出版者

和洋女子大学

雑誌

和洋女子大学紀要 = The journal of Wayo Women's University (ISSN:18846351)

巻号頁・発行日

vol.53, pp.59-70, 2013-03

---

本稿はSFというジャンルに代表される科学的世界観を超出した存在/現象理解をプレゼンテーションの基軸に据えた思弁的アニメ作品 Ergo Proxy を対象にして、形而上的映像表現に仮託し得る“意味”の全方位的拡張を模索することにより、現実と仮構を連続体として捕捉する統括的なシステム理論の適用を通して神と人の位格的遷移を辿った神話的表象の註解を試みるものである。そこには存在と現象、概念と質料、記述と創造の相互変換を可能にする仮想的基幹原理を反映した二次創作的記述/論考が企図されている。

著者

Noriko Nakajima Satoru Hata Yuko Sato Minoru Tobiume Harutaka Katano Keiko Kaneko Noriyo Nagata Michiyo Kataoka Akira Ainai Hideki Hasegawa Masato Tashiro Makoto Kuroda Tamami Odai Nobuyuki Urasawa Tomoyoshi Ogino Hiroaki Hanaoka Masahide Watanabe Tetsutaro Sata

出版者

National Institute of Infectious Diseases

雑誌

Japanese Journal of Infectious Diseases (ISSN:13446304)

巻号頁・発行日

vol.63, no.1, pp.67-71, 2010-01-29 (Released:2022-03-31)

参考文献数

1

被引用文献数

2 57

---

We report the pathological and virological findings of the first autopsy case of the 2009 pandemic influenza (A/H1N1pdm) virus infection in Japan. A man aged 33 years with chronic heart failure due to dilated cardiomyopathy, mild diabetes mellitus, atopic dermatitis, bronchial asthma, and obesity died of respiratory failure and multiple organ dysfunction syndrome. Macroscopic examination showed severe plumonary edema and microscopically the lung sections showed very early exudative-stage diffuse alveolar damage (DAD). Immunohistochemistry revealed proliferation of the influenza (A/H1N1pdm) virus in alveolar epithelial cells, some of which expressed SAα2-3Gal on the cell surface. Influenza (A/H1N1pdm) virus genomic RNA and mRNA were also detected in alveolar epithelial cells. Real-time PCR revealed 723 copies/cell in the left lower lung section from which the influenza (A/H1N1pdm) virus was isolated. Electron microscopic analysis revealed filamentous viral particles in the lung tissue. The concentrations of various cytokines/chemokines in the serum and the autopsied lung tissue were measured. IL-2R, IL-6, IL-8, IL-10, IFN-α, MCP-1, and MIG levels were elevated in both. These findings indicated a case of viral pneumonia caused by influenza (A/H1N1pdm) virus infection, showing characteristic pathological findings of the early stage of DAD.

著者

黒田 誠 MAKOTO KURODA

出版者

和洋女子大学

雑誌

和洋女子大学紀要 = The journal of Wayo Women's University (ISSN:18846351)

巻号頁・発行日

vol.52, pp.49-60, 2012-03

著者

黒田 誠 MAKOTO KURODA

出版者

和洋女子大学

雑誌

和洋女子大学紀要 = The journal of Wayo Women's University (ISSN:18846351)

巻号頁・発行日

vol.51, pp.79-89, 2011-03

著者

Tsuyoshi Sekizuka Kentaro Itokawa Masumichi Saito Michitsugu Shimatani Shutoku Matsuyama Hideki Hasegawa Tomoya Saito Makoto Kuroda

出版者

National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee

雑誌

Japanese Journal of Infectious Diseases (ISSN:13446304)

巻号頁・発行日

pp.JJID.2021.844, (Released:2022-02-28)

参考文献数

12

被引用文献数

22

---

Prominent genomic recombination has been observed between the Delta and Alpha variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) isolated from clinical specimens in Japan. Interestingly, the recombination variant detected in this study carries a spike protein identical to the one in the domestic Delta variant, thereby suggesting that further risks would not be concerned with infectivity and immune escape. The recombinant has been classified as XC lineage in the PANGOLIN database. It is necessary to intensively study such marked genetic variations and characterize the emerging variants after careful verification of their lineage and clade assignment.

著者

黒田 誠 Makoto KURODA

出版者

和洋女子大学

雑誌

和洋女子大学紀要 (ISSN:18846351)

巻号頁・発行日

vol.54, pp.49-61, 2014-03

---

映画作品Peter Pan と原作の文学作品Peter and Wendy を対象にして、それぞれのシーンやストーリーの詳細項目の対比から同等性と差異性の要素となる具体例を検証することにより、作品の保有する固有名詞概念に関する同等性判断の外延範囲の拡張を要求すると思われる存在論的問題性についての考察を試みる。手法としては観念小説の概念記述と映画作品の映像記述の間の種々の位相変換の過程を辿ることにより、量子的多世界解釈における平行宇宙において指摘し得ると思われる間世界的存在同一性と類比的な、意味空間における相当的同等性と可能態における分岐的発現可能性に対する示唆として仮構記述の内実を評価し、人格や現象において指摘し得ると同様の多宇宙的存在発現様態が映像的仮構において変換記述されていることの実例を示す。

著者

Fumihiko Takeuchi Tsuyoshi Sekizuka Akifumi Yamashita Yumiko Ogasawara Katsumi Mizuta Makoto Kuroda

出版者

National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee

雑誌

Japanese Journal of Infectious Diseases (ISSN:13446304)

巻号頁・発行日

vol.67, no.1, pp.62-65, 2014 (Released:2014-01-22)

参考文献数

13

被引用文献数

21 38

---

Next-generation DNA sequencing technologies have led to a new method of identifying the causative agents of infectious diseases. The analysis comprises three steps. First, DNA/RNA is extracted and extensively sequenced from a specimen that includes the pathogen, human tissue and commensal microorganisms. Second, the sequenced reads are matched with a database of known sequences, and the organisms from which the individual reads were derived are inferred. Last, the percentages of the organisms' genomic sequences in the specimen (i.e., the metagenome) are estimated, and the pathogen is identified. The first and last steps have become easy due to the development of benchtop sequencers and metagenomic software. To facilitate the middle step, which requires computational resources and skill, we developed a cloud-computing pipeline, MePIC: “Metagenomic Pathogen Identification for Clinical specimens.” In the pipeline, unnecessary bases are trimmed off the reads, and human reads are removed. For the remaining reads, similar sequences are searched in the database of known nucleotide sequences. The search is drastically sped up by using a cloud-computing system. The webpage interface can be used easily by clinicians and epidemiologists. We believe that the use of the MePIC pipeline will promote metagenomic pathogen identification and improve the understanding of infectious diseases.

著者

Hiroki Ozawa Shigeru Tajima Eri Nakayama Kengo Kato Akifumi Yamashita Tsuyoshi Sekizuka Makoto Kuroda Shuzo Usuku

出版者

National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee

雑誌

Japanese Journal of Infectious Diseases (ISSN:13446304)

巻号頁・発行日

pp.JJID.2017.256, (Released:2017-12-26)

参考文献数

14

被引用文献数

3

---

Zika virus (ZIKV) infection has been documented within Central and South America, Asia, and Africa. Here we report the isolation of virus from a patient infected with ZIKV returning to Japan from the Dominican Republic. The ZIKV strain was imaged by electron microscopy and its complete genome sequence was analyzed. Phylogenetic analysis and molecular characterization revealed that the strain was of the Asian lineage, and carried two unique mutations in its NS5 region. These mutations are characteristic of strains that originated in the Dominican Republic and the USA in 2016.