著者

Kimiko Tomioka Kenji Uno Masahiro Yamada

出版者

The Japanese Society for Hygiene

雑誌

Environmental Health and Preventive Medicine (ISSN:1342078X)

巻号頁・発行日

vol.28, pp.7, 2023 (Released:2023-01-21)

参考文献数

34

被引用文献数

5

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Background: Many previous studies have reported COVID-19 vaccine effectiveness, but there are few studies in Japan. This community-based, retrospective observational study investigated the association between vaccination status and COVID-19-related health outcomes in COVID-19 patients by SARS-CoV-2 variant type.Methods: The study participants were 24,314 COVID-19 patients aged 12 or older whose diagnoses were reported to the Nara Prefecture Chuwa Public Health Center from April 2021 to March 2022, during periods when the alpha, delta, and omicron variants of COVID-19 were predominant. The outcome variables were severe health consequences (SHC) (i.e., ICU admission and COVID-19-related death), hospitalization, and extension of recovery period. The explanatory variable was vaccination status at least 14 days prior to infection. Covariates included gender, age, population size, the number of risk factors for aggravation, and the number of symptoms at diagnosis. The generalized estimating equations of the multivariable Poisson regression models were used to estimate the adjusted incidence proportion (AIP) and 95% confidence interval (CI) for each health outcome. We performed stratified analyses by SARS-CoV-2 variant type, but the association between vaccination status and COVID-19-related health outcomes was stratified only for the delta and omicron variants due to the small number of vaccinated patients during the alpha variant.Results: Of the 24,314 participants, 255 (1.0%) had SHC; of the 24,059 participants without SHC, 2,102 (8.7%) were hospitalized; and of the 19,603 participants without SHC, hospitalization, and missing data on recovery period, 2,960 (15.1%) had extension of recovery period. Multivariable Poisson regression models showed that regardless of SARS-CoV-2 variant type or health outcome, those who received two or more vaccine doses had significantly lower risk of health outcomes than those who did not receive the vaccine, and there was a dose-response relationship in which the AIP for health outcomes decreased with an increased number of vaccinations.Conclusion: A higher number of vaccinations were associated with lower risk of COVID-19-related health outcomes, not only in the delta variant but also in the omicron variant. Our findings suggest that increasing the number of COVID-19 vaccine doses can prevent severe disease and lead to early recovery of patients not requiring hospitalization.

著者

山田 真裕 坂本 元来 Masahiro Yamada Genki Sakamoto

雑誌

法と政治 (ISSN:02880709)

巻号頁・発行日

vol.61, no.4, pp.163(761)-204(802), 2011-01-20

著者

Masahiro Yamada Eiji Hosoi Hidetoshi B. Tamate Junco Nagata Shirow Tatsuzawa Hiroyuki Tado Shinobu Ozawa

出版者

THE MAMMAL SOCIETY OF JAPAN

雑誌

Mammal Study (ISSN:13434152)

巻号頁・発行日

vol.31, no.1, pp.23-28, 2006 (Released:2006-07-08)

参考文献数

17

被引用文献数

22

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Nucleotide sequences of sika deer (Cervus nippon) collected from the eastern part of Shikoku Island were investigated & compared with those from other areas. Nucleotide sequence of the whole D-loop region of the mitochondrial DNA was determined by direct sequencing technique for each sample. The phylogenetic tree constructed by the sequences indicates that sika deer from Shikoku Island are divided into two distinct lineages: the northern Japan group and the southern Japan group. Proportion of the northern Japan lineage was higher in the northeastern part of the sampling area. There was no border between the distribution of the two lineages, rather it seemed that their distribution intermingled. Besides, there were locations where both lineages were found within a small area. These results indicate that two lineages might be hybridized in some areas of eastern Shikoku.

著者

大嶽 秀夫 谷 聖美 橋本 信之 山田 真裕 Hideo Otake Satomi Tani Nobuyuki Hashimoto Masahiro Yamada

雑誌

総研ジャーナル

巻号頁・発行日

no.92, pp.27-36, 2008-03-31

著者

Masahiro Yamada Eiji Hosoi Junco Nagata Hidetoshi B. Tamate Hiroyuki Tado

出版者

日本哺乳類学会

雑誌

Mammal Study (ISSN:13434152)

巻号頁・発行日

vol.32, no.3, pp.121-127, 2007 (Released:2007-10-10)

参考文献数

22

被引用文献数

12 2

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Samples of the sika deer (Cervus nippon) were collected from Kyushu and Shikoku Islands of Japan and surrounding areas, and their nucleotide sequences were analyzed. Sequences of the whole control region of the mitochondrial DNA were determined and phylogenetic trees were constructed using the neighbor-joining method and the maximum likelihood method. We also investigated gene genealogies for the sequences using the statistical parsimony network approach. Phylogenetic trees showed that only the Yakushima/Tanegashima populations were genetically distant from other populations. The statistical parsimony network, however, indicated a close relationship of the Miyazaki populations to some of the Shikoku populations. It was suggested that Shikoku Island played an important role in the divergence from the southern Japan lineage of C. nippon.

著者

山田 昌弘 Masahiro Yamada

雑誌

社会学部紀要 (ISSN:04529456)

巻号頁・発行日

no.別冊, pp.29-52, 2011-03-15

著者

Masato Narita Masahiro Yamada Michiko Tsushima Natsumi Kudo Tomo Kato Yoshikazu Yokono Yuichi Toyama Maiko Senoo Manabu Yonekura Noritomo Narita Yoshihiro Kimura Kaori Sawada Itoyo Tokuda Hirofumi Tomita

出版者

International Heart Journal Association

雑誌

International Heart Journal (ISSN:13492365)

巻号頁・発行日

pp.18-511, (Released:2019-04-25)

参考文献数

37

被引用文献数

11

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Although there are several diagnostic criteria for left ventricular hypertrophy (LVH), their sensitivity remains low. A recent study reported that the sum of the amplitude of the deepest S wave in any lead (SD) and the S wave in lead V4 (SV4) (SD + SV4) improved sensitivity compared with commonly used criteria. To test whether this new formula improves sensitivity in the Japanese general population, we analyzed 12-lead electrocardiograms for Japanese residents participating in the Iwaki Health Promotion Project (n = 866). Left ventricular mass was calculated by echocardiography, indicating that 156 (18%) of the study population had LVH. In receiver operating characteristic analyses, the sum of the R wave in limb lead Ι (RLΙ) and the S wave in V4 (SV4) (RLΙ + SV4) showed a higher area under the curve (AUC = 0.76) than the Sokolow-Lyon voltage criteria (0.61) and the SD + SV4 criteria (0.63), and almost the same AUC as the Cornell voltage criteria (0.74) and the Cornell product criteria (0.76). The validation study also showed similar results. The cutoff values of RLΙ + SV4 criteria were ≥1.6 mV in men and ≥1.4 mV in women with a sensitivity of 39% and a specificity of 89%, whereas the sensitivity and specificity calculated based on SD + SV4 criteria were 21% and 94%, respectively. Thus, the diagnostic criterion of RLΙ + SV4 seems to be more useful than the previous criteria for diagnosing LVH in the Japanese general population.

著者

山田 昌裕 Masahiro YAMADA

出版者

恵泉女学園大学紀要委員会

雑誌

恵泉女学園大学紀要 (ISSN:18812554)

巻号頁・発行日

no.27, pp.107-125, 2015-02

著者

山田 昌裕 ヤマダ マサヒロ Masahiro YAMADA

雑誌

恵泉女学園大学紀要 = Keisen University Bulletin

巻号頁・発行日

vol.23, pp.111-126, 2011-02

著者

山田 真裕 Masahiro Yamada

雑誌

関西学院大学高等教育研究 (ISSN:21859124)

巻号頁・発行日

no.5, pp.59-71, 2015-03-13