著者

Keisuke Ikegami Megumi Saito Shungo Imai Hayato Kizaki Osamu Yasumuro Ryohkan Funakoshi Satoko Hori

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.46, no.1, pp.95-101, 2023-01-01 (Released:2023-01-01)

参考文献数

15

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To prevent denosumab-induced hypocalcemia in patients with renal dysfunction, combination therapy with 1α,25-dihydroxy-vitamin D3 (active vitamin D) is recommended. We previously developed a risk prediction model for hypocalcemia in patients with cholecalciferol/calcium (natural vitamin D). However, the prescription status and the risk factors of patients with active vitamin D have not been identified, so we designed this retrospective observational study using a large practice database covering June 2013 to May 2020 to analyze prescription status and risk factors. Patients were classified according to vitamin D type. After that, factors associated with development of hypocalcemia in patients with active vitamin D were explored. Univariate analysis was conducted to compare patient backgrounds between the hypocalcemia and non-hypocalcemia groups. Receiver operating characteristic analysis was conducted to evaluate the predictive potential of the extracted factors. Of the 33442 patients who received denosumab, 22347 and 3560 patients were co-administered natural and active vitamin D, respectively. Patients with active vitamin D had significantly lower renal function (estimated glomerular filtration rate (eGFR) median: 74.0 vs. 69.7 mL/min/1.73 m2), but some patients (23.6%) with sufficient renal function (eGFR ≥90) were also receiving active vitamin D. Of the 3560 patients with active vitamin D, non-hypocalcemia (n = 166) and hypocalcemia (n = 17) groups who met the study criteria were analyzed. Renal function was lower in the hypocalcemia group, and alkaline phosphatase gave the best discrimination. High aspartate aminotransferase (AST), renal dysfunction, high alkaline phosphatase (ALP), and low hemoglobin may be significant factors in risk prediction for hypocalcemia in patients with active vitamin D.

著者

齋藤 めぐみ 山田 和芳 スタッフ リチャード 中川 毅 米延 仁志 原口 強 竹村 恵二 ラムジー クリストファー Megumi SAITO-KATO Kazuyoshi YAMADA Richard A STAFF Takeshi NAKAGAWA Hitoshi YONENOBU Tsuyoshi HARAGUCHI Keiji TAKEMURA RAMSEY Christopher BRONK

出版者

東京地学協会

雑誌

地学雑誌 = Journal of geography (ISSN:0022135X)

巻号頁・発行日

vol.122, no.3, pp.493-501, 2013

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Sediment cores from Lake Suigetsu, Japan, reveal the absence of seawater intrusion into the lake caused by the historically documented tsunami of AD 1586 (Tensho Tsunami). A highprecision chronology of the cores established by Bayesian modeling radiocarbon determinations enables us to ascertain the precise position of the historical event in the sediment depth. Diatom analysis of the core shows that a diatom assemblage dominated by freshwater taxa persisted through the period. This makes a clear contrast with the core section around AD 1664 when the lake was artificially connected to the sea by a channel, and the subsequent intrusion of seawater was clearly recorded in the sediment cores by the occurrence of marine diatom fossils.

著者

齋藤 恵美 サイトウ メグミ Megumi Saito

雑誌

立教ビジネスデザイン研究

巻号頁・発行日

vol.16, pp.45-59, 2019

著者

Kazufumi KASUYA Nobuyuki TANAKA Fumi OSHIMA Nozomi FUJISAWA Megumi SAITO Katsunori TAGAMI Hidekazu NIWA Kazumi SASAI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.18-0656, (Released:2019-04-24)

被引用文献数

2

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Strangles is a commonly diagnosed and important infectious disease of equids worldwide, caused by Streptococcus equi subsp. equi. We determined the SeM genotypes of S. equi isolated from imported horses at the Japanese border within the past 8 years, which allowed us to classify 12 strains isolated from these horses from each exporter into four allelic groups. These alleles were different from the alleles of past isolates found in Japan. Furthermore, four strains classified into the same allele were isolated from horses from one exporter over several years. In this study, S. equi isolates from different exporters had different SeM alleles. Attention to the hygiene status of farms will be necessary to prevent the incursion of strangles.