著者

伊藤 聡 Satoshi Ito

出版者

放送大学

雑誌

放送大学文化科学研究 = The OUJ Journal of Arts and Sciences

巻号頁・発行日

vol.2, pp.102-109, 2023-02-20

著者

Hiroe Sato Junichiro James Kazama Akira Murasawa Hiroshi Otani Asami Abe Satoshi Ito Hajime Ishikawa Kiyoshi Nakazono Takeshi Kuroda Masaaki Nakano Ichiei Narita

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.55, no.2, pp.121-126, 2016 (Released:2016-01-15)

参考文献数

33

被引用文献数

3 33

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Objective Rheumatoid arthritis (RA) is a chronic inflammatory disease accompanied by periarticular and systemic osteoporosis. Fibroblast growth factor 23 (FGF23), which is mainly produced by osteocytes, circulates to the kidneys and regulates bone metabolism. We herein assessed serum FGF23 and its relationship to inflammation and osteoporosis in patients with RA. Methods Sixty-one patients with RA were included. Serum concentrations of FGF23 were determined using a sandwich enzyme-linked immunosorbent assay. Results The mean (± standard deviation) serum FGF23 concentration was 34.9±9.2 (range, 21.0-61.0) pg/mL. The serum FGF23 level was significantly and positively correlated with the erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) levels, disease activity score-28 based on the ESR (DAS-28 ESR) and DAS-28 CRP (r=0.261, p=0.044, r=0.280, p=0.029, r=0.409, p=0.001 and r=0.421, p=0.001, respectively). The serum matrix metalloproteinase-3 level was also significantly and positively correlated with the serum FGF23 level (r=0.331, p=0.015). Concentrations of type I collagen cross-linked N-telopeptide in the serum was significantly correlated with the serum FGF23 level (r=0.272, p=0.034). Neither the bone mineral density in the femoral neck nor lumbar was significantly correlated with the serum FGF23 level. Serum phosphate, calcium, 25-hydroxy vitamin D, and intact parathyroid hormone were not related to the serum FGF23 level. Conclusion In patients with RA, serum FGF23 is correlated with inflammation, the disease activity of RA, and bone absorption markers. Serum FGF23 may be associated with abnormal bone absorption related to RA inflammation. Further studies are necessary to clarify the mechanism underlying this association.

著者

Shigeaki Moriura Satoko Ono Kumiko Sugiyama Satoshi Ito Yuji Ito

出版者

Japan Society of Ningen Dock

雑誌

Ningen Dock International (ISSN:21878072)

巻号頁・発行日

vol.3, no.1, pp.20-22, 2016 (Released:2018-12-10)

参考文献数

5

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Background: The management of asymptomatic pneumonia-like opacity detected by CT has not been clarified.Methods: We reviewed 12 cases of asymptomatic pneumonia-like opacity from 2,762 chest CTs performed at our check-up center between 2012 and 2014. Cases under treatment for respiratory disorders and those suspicious of specific infections were excluded.Results: In all 12 cases, CT findings of pneumonia-like opacity disappeared without chemotherapy.Conclusion: Patients with asymptomatic pneumonia-like opacity can be managed by observation if chronic respiratory disorders and specific infections have been ruled out.

著者

伊藤 哲 Satoshi Ito

出版者

麗澤大学経済学会

雑誌

麗澤学際ジャーナル = Reitaku Journal of Interdisciplinary Studies (ISSN:21895333)

巻号頁・発行日

vol.23, pp.165-175, 2015-03-20

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I intend to insist that both Keynes and Smith considered the common respect of Economics as one of Social Science. Keynes stated that Economics was one of Moral Science, as Smith pointed out the difference between Moral philosophy and Natural philosophy. However, Hume emphasized Moral philosophy should adopted Newton's experimental method in the analysis of human nature. Keynes doubted whether human acts were based on Mathematical expectation, and indicated the instability due to the characteristic of human nature. Equally Smith submitted that the casuists made mistakes their end for the rules of justice. Criticizing Casuistry, Keynes and Smith recognized that Economics connoted the insecurity of human nature which created social dynamics.

著者

Taro Sugai Kohei Takano Shohei Ouchi Satoshi Ito

出版者

Japanese Society for Magnetic Resonance in Medicine

雑誌

Magnetic Resonance in Medical Sciences (ISSN:13473182)

巻号頁・発行日

pp.mp.2020-0073, (Released:2021-02-11)

参考文献数

24

被引用文献数

1

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Purpose: To improve the performance of a denoising convolutional neural network (DnCNN) and to make it applicable to images with inhomogeneous noise, a refinement involving an activation function (AF) and an application of the refined method for inhomogeneous-noise images was examined in combination with parallelized image denoising.Methods: Improvements in the DnCNN were performed by three approaches. One is refinement of the AF of each neural network that constructs the DnCNN. Swish was used in the DnCNN instead of rectifier linear unit. Second, blind noise removal was introduced to the DnCNN in order to adapt spatially variant noises. Third, blind noise removal was applied to parallelized image denoising, referred to herein as ParBID. The ParBID procedure is as follows: (1) adjacent 2D slice images are linearly combined to obtained higher peak SNR (PSNR) images, (2) combined images with different weight coefficients are denoised using the blind DnCNN, and (3) denoised combined images are separated into original position images by algebraic calculation.Results: Experimental studies showed that the PSNR and the structural similarity index (SSIM) were improved by using Swish for all noise levels, from 2.5% to 7.5%, as compared to the conventional DnCNN. It was also shown that a well-trained CNN could remove spatially variant noises superimposed on images. Experimental studies with ParBID showed that the greatest PSNR and SSIM improvements were obtained at the middle slice when three slice images were used for linear image combination. More fine structures of images and image contrast remained when the proposed ParBID procedure was used.Conclusion: Swish can improve the denoising performance of the DnCNN, and the denoising performance and effectiveness were further improved by ParBID.

著者

Shohei Ouchi Satoshi Ito

出版者

Japanese Society for Magnetic Resonance in Medicine

雑誌

Magnetic Resonance in Medical Sciences (ISSN:13473182)

巻号頁・発行日

pp.mp.2019-0139, (Released:2020-07-02)

参考文献数

28

被引用文献数

8

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Purpose: A deep residual learning convolutional neural network (DRL-CNN) was applied to improve image quality and speed up the reconstruction of compressed sensing magnetic resonance imaging. The reconstruction performances of the proposed method was compared with iterative reconstruction methods.Methods: The proposed method adopted a DRL-CNN to learn the residual component between the input and output images (i.e., aliasing artifacts) for image reconstruction. The CNN-based reconstruction was compared with iterative reconstruction methods. To clarify the reconstruction performance of the proposed method, reconstruction experiments using 1D-, 2D-random under-sampling and sampling patterns that mix random and non-random under-sampling were executed. The peak-signal-to-noise ratio (PSNR) and the structural similarity index (SSIM) were examined for various numbers of training images, sampling rates, and numbers of training epochs.Results: The experimental results demonstrated that reconstruction time is drastically reduced to 0.022 s per image compared with that for conventional iterative reconstruction. The PSNR and SSIM were improved as the coherence of the sampling pattern increases. These results indicate that a deep CNN can learn coherent artifacts and is effective especially for cases where the randomness of k-space sampling is rather low. Simulation studies showed that variable density non-random under-sampling was a promising sampling pattern in 1D-random under-sampling of 2D image acquisition.Conclusion: A DRL-CNN can recognize and predict aliasing artifacts with low incoherence. It was demonstrated that reconstruction time is significantly reduced and the improvement in the PSNR and SSIM is higher in 1D-random under-sampling than in 2D. The requirement of incoherence for aliasing artifacts is different from that for iterative reconstruction.

著者

Masashi Matsuyama Takeshi Suzuki Hiroto Tsuboi Satoshi Ito Mizuko Mamura Daisuke Goto Isao Matsumoto Akito Tsutsumi Takayuki Sumida

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.46, no.11, pp.771-774, 2007 (Released:2007-06-01)

参考文献数

14

被引用文献数

59 66

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We report three cases of multicentric Castleman's disease (MCD) successfully treated with anti-interleukin-6 receptor antibody (tocilizumab). Tocilizumab was administered intravenously at a dose of 8 mg/kg every 2 weeks. In each case, tocilizumab alleviated symptoms, including generalized fatigue, pyrexia, and alleviated biochemical abnormalities, including anemia, hypoalbuminemia, hypergammaglobulinemia, and increased C-reactive protein (CRP). Side effects included hypercholesterolemia, acute pyelonephritis, mild inflammation of the parotid glands, and upper respiratory system inflammation. Other severe side effects were not observed. These results indicate that tocilizumab is effective for the treatment of MCD. This is the first report on tocilizumab efficacy for Castleman's disease after approval for use for Castleman's disease.

著者

Tomoki Watanabe Satoshi Ito Kentaro Yokoi

出版者

Information and Media Technologies 編集運営会議

雑誌

Information and Media Technologies (ISSN:18810896)

巻号頁・発行日

vol.5, no.2, pp.659-667, 2010 (Released:2010-06-15)

参考文献数

23

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The purpose of the work reported in this paper is to detect humans from images. This paper proposes a method for extracting feature descriptors consisting of co-occurrence histograms of oriented gradients (CoHOG). Including co-occurrence with various positional offsets, the feature descriptors can express complex shapes of objects with local and global distributions of gradient orientations. Our method is evaluated with a simple linear classifier on two well-known human detection benchmark datasets: “DaimlerChrysler pedestrian classification benchmark dataset” and “INRIA person data set”. The results show that our method reduces the miss rate by half compared with HOG, and outperforms the state-of-the-art methods on both datasets. Furthermore, as an example of a practical application, we applied our method to a surveillance video eight hours in length. The result shows that our method reduces false positives by half compared with HOG. In addition, CoHOG can be calculated 40% faster than HOG.