著者

Ryuichi SAITO Naoki SATO Yoichi OKINO Dian-Sheng WANG Genichiro SEO

出版者

BMFH Press

雑誌

Bioscience of Microbiota, Food and Health (ISSN:21863342)

巻号頁・発行日

vol.42, no.2, pp.124-130, 2023 (Released:2023-04-01)

参考文献数

33

被引用文献数

2

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Clostridium butyricum TO-A, Enterococcus faecium T-110, and Bacillus subtilis TO-A are sold as oral probiotic preparations and reportedly exhibit many beneficial effects on the health of hosts, including humans and livestock. In this study, we compared the ability of these clinically applied probiotic bacteria with Escherichia coli OP50 in extending the lifespan of Caenorhabditis elegans. To compare the C. elegans lifespan-extending effects of the three bacteria, experiments were performed using a nematode growth medium containing a small amount of trypticase soy agar. The maximum lifespans of worms fed C. butyricum TO-A, E. faecium T-110, or B. subtilis TO-A increased by 11, 12, and 26%, respectively, compared with worms fed E. coli OP50. In addition, we conducted a metabolomic analysis of methanol extracts of B. subtilis TO-A cells, which exhibited the strongest lifespan-extending effect on C. elegans among the probiotic bacteria tested in this study. As a result, 59 candidate substances involved in extending the lifespan of C. elegans were identified in B. subtilis TO-A cells.

著者

Huihuang Huang Bing Song Zhe Xu Yanmei Jiao Lei Huang Peng Zhao Jiagan Huang Zihan Zhou Zhuanghong Zhao Jing Tian Yuting Zhou Fu-sheng Wang Tianjun Jiang

出版者

National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee

雑誌

Japanese Journal of Infectious Diseases (ISSN:13446304)

巻号頁・発行日

pp.JJID.2020.298, (Released:2020-08-01)

参考文献数

35

被引用文献数

17

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To analyze clinical characteristics and potential predictors of disease severity in patients with COVID-19.Clinical data from 64 patients with COVID-19 were retrospectively analyzed. Of the 64 patients, 37 were male and 27 were female. Their mean age was 47.8 years, 43 (67.2%) cases were non-severe, 21 (32.8%) were severe, and 2 patients (3.1%) died. Age and serum ferritin were significantly associated with COVID-19 severity. Repeated monitoring of ferritin, interleukin-6, C-reactive protein, lactic acid dehydrogenase, and erythrocyte sedimentation rate during COVID-19 treatment may assist the prediction of disease severity and evaluation of treatment effects. There were no significant differences in the duration of severe illness or the number of days on high-level respiratory support between a low-dose methylprednisolone group and a high-dose methylprednisolone group. The mean number of days in hospital in the high dose group was higher than that in the low-dose group. Repeated monitoring of ferritin, interleukin-6, C-reactive protein, lactic acid dehydrogenase, and erythrocyte sedimentation rate during COVID-19 treatment may assist the prediction of disease severity and evaluation of treatment effects.

著者

Muneo HORI Sheng WANG Lalith WIJERATHNE Tsuyohi ICHIMURA

出版者

Japan Society of Civil Engineers

雑誌

Journal of JSCE (ISSN:21875103)

巻号頁・発行日

vol.6, no.1, pp.12-23, 2018 (Released:2018-01-20)

参考文献数

22

被引用文献数

1

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This paper seeks to reformulate moving particle semi-implicit method (MPS) in order to provide a mathematical interpretation of the method. It is shown that gradient and Laplace operators are evaluated by using volume integral of the Taylor series expansion of a target function and that the form of the volume integral evaluation of the differential operators is similar to MPS, suggesting that the volume integral evaluation is a mathematical interpretation of MPS. Numerical experiments using one-dimensional setting indicate a possibility of improving the accuracy of computing the differential operators when the reformulated MPS is used. Remarks on directions towards improving the accuracy of MPS are made.

著者

Shanfa YU Akinori NAKATA Guizhen GU Naomi G. SWANSON Lihua HE Wenhui ZHOU Sheng WANG

出版者

独立行政法人 労働安全衛生総合研究所

雑誌

Industrial Health (ISSN:00198366)

巻号頁・発行日

vol.51, no.2, pp.180-192, 2013 (Released:2013-08-31)

参考文献数

56

被引用文献数

3 16

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The purpose of this study was to examine the association between psychosocial job stress (by the Job Control-Demand (JCD) model and Effort-Reward imbalance (ERI) model) and musculoskeletal (MS) symptoms among workers in China. Overall, 3,632 male and 1,706 female workers from 13 factories/companies participated in this study. Perceived job stress was evaluated by the Chinese version of the Job Content Questionnaire (JCQ) and ERI Questionnaire. Neck, shoulder and wrist symptoms were assessed by self-report during the past year. Workers reporting high job demands and low job control or high effort and low rewards had moderately increased risk for all MS symptoms. Odds ratios (ORs) were higher in workers reporting both high effort and low rewards. The combination of high physical job demands with low job control showed significant associations with MS symptoms. The effects of psychological demands on symptoms in women, effort and effort-reward imbalance on symptoms among both genders were increased as the number of regions with symptoms increased. These results suggest that high job strain and ERI are associated with neck, shoulder and wrist symptoms in Chinese factory workers independent of individual factors, physical factors, and other psychological variables.