著者

Hideaki Goto Yasuhiro Kumahara Shoichiro Uchiyama Yoshiya Iwasa Tomoru Yamanaka Rinako Motoyoshi Shun Takeuchi Sho Murata Takashi Nakata

出版者

Fuji Technology Press Ltd.

雑誌

Journal of Disaster Research (ISSN:18812473)

巻号頁・発行日

vol.14, no.6, pp.894-902, 2019-09-01 (Released:2019-09-01)

参考文献数

12

被引用文献数

7

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Record-breaking heavy rainfall in July 2018 caused an extremely large number of slope movements over a broad area of western Japan. We mapped the distribution of slope movements in the southern part of Hiroshima Prefecture through an interpretation of aerial photographs that were acquired after the rainfall by the Geospatial Information Authority of Japan, and counted a total of 8,497 slope-movement starting points. The widespread distribution of slope movements – from Etajima City of Hiroshima Prefecture to Kasaoka City of Okayama Prefecture – suggests that the heavy rain affected a very large area. The starting points of debris flow during this disaster were commonly close to the crest of mountain ranges. We compared the distribution of slope movements to the 24-hr rainfall accumulation during the heaviest rainfall event to clarify the factors that caused regional difference in slope-movement distribution. We found the area of highest density of the slope movements was consistent with the area receiving a cumulative rainfall of >250 mm. This observation indicated that the position of slope-movement starting points was not related to differences in geology.

著者

Hiroaki Shimokawa Tomohiko Shindo Aiko Ishiki Naoki Tomita Sadamitsu Ichijyo Tasuku Watanabe Takashi Nakata Kumiko Eguchi Yoku Kikuchi Takashi Shiroto Jun Takahashi Satoshi Yasuda Hiroyuki Arai

出版者

Tohoku University Medical Press

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

pp.2022.J078, (Released:2022-09-15)

被引用文献数

9

著者

Jeffrey S. Perez Hiroyuki Tsutsumi Mabelline T. Cahulogan Desiderio P. Cabanlit Ma. Isabel T. Abigania Takashi Nakata

出版者

Fuji Technology Press Ltd.

雑誌

Journal of Disaster Research (ISSN:18812473)

巻号頁・発行日

vol.10, no.1, pp.74-82, 2015-02-01 (Released:2019-07-01)

参考文献数

35

被引用文献数

7

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The 1,250-km-long, NNW-trending, arc-parallel Philippine fault, one of the world’s most active tectonic structures, traverses the Philippine archipelago and has been the source of surface-rupturing earthquakes during the last four centuries. In this paper, we will discuss Philippine fault distribution and segmentation in Mindanao Island by integrating detailed fault mapping together with new geological and paleoseismic data and the analysis of historical surface-rupturing earthquakes. Using geometric segmentation criteria, we have identified nine geometric segments separated by discontinuities such as en echelon steps, bends, changes in strike, gaps, steps and bifurcation in the surface trace. Fault segments ranges from 20 to 100 km in length and are capable of generating earthquakes of Mw6.6 to Mw7.4. The results of our study have important implications for earthquake generation potential and seismic hazard assessment of the Philippine fault in Mindanao Island.

著者

Hiroaki Shimokawa Tomohiko Shindo Aiko Ishiki Naoki Tomita Sadamitsu Ichijyo Tasuku Watanabe Takashi Nakata Kumiko Eguchi Yoku Kikuchi Takashi Shiroto Jun Takahashi Satoshi Yasuda Hiroyuki Arai

出版者

Tohoku University Medical Press

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

vol.258, no.3, pp.167-175, 2022 (Released:2022-10-25)

参考文献数

30

被引用文献数

9

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The prevalence of Alzheimer’s disease (AD) has been rapidly increasing worldwide. We have developed a novel angiogenic therapy with low-intensity pulsed ultrasound (LIPUS), which is effective and safe in animal models of AD and vascular dementia. We performed two trials of LIPUS therapy for AD (mild cognitive impairment due to AD and mild AD); a roll-in open trial for safety, and a randomized, double-blind, placebo-controlled (RCT) trial for efficacy and safety. The LIPUS therapy was performed for whole brain through the bilateral temporal bones for one hour 3 times a week as one session under the special conditions (1.3 MPa, 32 cycles, 5% duty cycle) we identified. The LIPUS therapy was performed for one session in the roll-in trial, and 6 sessions in the RCT trial with 3-month intervals for 1.5 years. The primary endpoint was ADAS-J cog scores. The RCT trial was terminated prematurely due to the COVID-19 pandemic. In the roll-in trial (N = 5), no adverse effects were noted. In the RCT trial (N = 22), the worsening of ADAS-J cog scores tended to be suppressed in the LIPUS group compared with the placebo group at week 72 (P = 0.257). When responders were defined as those with no worsening of ADAS-J cog scores at week 72, the prevalence was 50% (5/10) and 0% (0/5) in the LIPUS and placebo groups, respectively (P = 0.053). No adverse effects were noted. These results suggest that the LIPUS therapy is safe and tends to suppress cognitive impairment although a next pivotal trial with a large number of subjects is warranted.

著者

Tokihiko MATSUDA Yasuhiro SUZUKI Takashi NAKATA Takashi KUMAMOTO Hiroshi UNE Kiyomine TERUMOTO Yoshiyuki MURAYAMA Takayuki NISHIYAMA Masaru YAMAGUCHI

出版者

The Association of Japanese Geographers

雑誌

地理学評論 (ISSN:13479555)

巻号頁・発行日

vol.77, no.12, pp.883-886, 2004-10-01 (Released:2008-12-25)

被引用文献数

1 1