著者

Hiroaki Isobe Takuya Takahashi Daikichi Seki Yosuke Yamashiki

出版者

Fuji Technology Press Ltd.

雑誌

Journal of Disaster Research (ISSN:18812473)

巻号頁・発行日

vol.17, no.2, pp.230-236, 2022-02-01 (Released:2022-02-01)

参考文献数

55

被引用文献数

1

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Space weather, or the disturbances of the plasma environment driven by the magnetic activities in the Sun in geospace, has become a potential source of disaster for modern society, which is increasingly dependent on its space infrastructure and large-scale power grids. Recently, independent pieces of evidence have been found that support the possibility of extremely intense space weather driven by a “superflare,” a solar phenomenon that modern society has never experienced. This paper reviews state-of-art studies of superflares and their potential impacts.

著者

Ryohei Kondo Kota Kasahara Takuya Takahashi

出版者

The Biophysical Society of Japan

雑誌

Biophysics and Physicobiology (ISSN:21894779)

巻号頁・発行日

pp.e190002, (Released:2022-02-08)

著者

Takuya Takahashi Hirofumi Saiki Akira Sato Seiko Kuwata Satoshi Nakano Yumi Sato Manami Akasaka Junichi Koizumi Hideaki Senzaki Kotaro Oyama

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-23-0147, (Released:2023-09-28)

参考文献数

21

被引用文献数

1

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Background: Although right ventricular (RV) enlargement may affect RV diastolic dysfunction assessed by end-diastolic forward flow (EDFF) in patients with repaired tetralogy of Fallot (TOF), EDFF may also be modified by left ventricular (LV) hemodynamics. We hypothesized that EDFF is affected by LV hemodynamics, not limited to RV diastolic stiffening.Methods and Results: Among 145 consecutive patients with repaired TOF who underwent catheterization, hemodynamic properties in 47 with consistent EDFF and 75 without EDFF were analyzed. Compared with patients without EDFF, those with EDFF had a large RV volume with a high regurgitant fraction. Although cardiac index and central venous pressure (CVP) were similar, contrast injection augmented CVP and LV end-diastolic pressure (EDP) in patients with vs. those without EDFF, suggesting compromised diastolic reserve. In patients with EDFF, the velocity–time integral (VTI) of EDFF was positively correlated with LVEDP and systemic vascular resistance, in addition to RV EDP. EDFF-VTI was correlated with hepatic venous wedge pressure and markers of hepatic dysfunction. Subanalysis of the older (≥6 years) half of the study cohort revealed that EDFF was associated with bi-atrial enlargement independent of RV volume, highlighting the pronounced role of EDFF on the diastolic property in the aged cohort.Conclusions: EDFF-VTI in patients with repaired TOF reflects RV diastolic dysfunction, affected by the left heart system. EDFF-VTI indicates blood stagnation, which may be attributed to end-organ damage.

著者

Takashi Hirai Takuya Takahashi Tomoyuki Tanaka Takayuki Motoyoshi Yu Matsukura Masato Yuasa Hiroyuki Inose Toshitaka Yoshii Atsushi Okawa

出版者

The Japanese Society for Spine Surgery and Related Research

雑誌

Spine Surgery and Related Research (ISSN:2432261X)

巻号頁・発行日

vol.6, no.3, pp.252-260, 2022-05-27 (Released:2022-05-27)

参考文献数

21

被引用文献数

9

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Introduction: Chemonucleolysis with condoliase (chondroitin sulfate ABC endolyase) has been used to treat patients with lumbar disc herniation (LDH) in Japan since 2018. In this study, we retrospectively investigated clinical outcomes in patients who received an intradiscal condoliase injection for LDH and sought to identify significant predictors of good outcome.Methods: Indications for treatment were as follows: (1) unilateral leg pain with or without back pain, (2) nerve root compression caused by LDH confirmed on magnetic resonance imaging (MRI), and (3) leg pain resistant to at least 1 month of conservative treatment, including medication, nerve root block, or physical therapy. Patients with motor weakness or a history of severe allergy were excluded, as were those with the foraminal or sequestrated type of LDH. The injection was defined as effective if the numeric rating scale score for leg pain improved by ≥50% at 6 months post-treatment.Results: A total of 52 patients (mean age, 45.0 years) were enrolled and classified according to whether the injection was effective (E group, n=40, 76.9%) or less effective (L group, n=9, 17.3%). Three patients (5.8%) underwent herniotomy for residual pain within 6 months of the injection. There were no severe adverse events. Reduction of herniation was seen on MRI more often in the E group than in the L group. The effectiveness in patients with transligamentous LDH was similar to that in patients with subligamentous LDH. High-intensity signal change in the area of LDH on pretreatment T2-weighted MRI was a significant predictor of successful leg pain relief.Conclusions: An intradiscal condoliase injection was a safe and effective treatment for painful radiculopathy caused by LDH. Leg pain was more likely to improve in patients with high-intensity signal change in the area of LDH before treatment.

著者

Kota Kasahara Hiroki Terazawa Hayato Itaya Satoshi Goto Haruki Nakamura Takuya Takahashi Junichi Higo

出版者

The Biophysical Society of Japan

雑誌

Biophysics and Physicobiology (ISSN:21894779)

巻号頁・発行日

pp.BSJ-2020013, (Released:2020-10-15)

被引用文献数

9