文献一覧: Yoshihisa Nakano (著者)

3 0 0 0 OA Effects of Tobacco Smoking on Cardiovascular Disease

著者: Takahisa Kondo Yoshihisa Nakano Shiro Adachi Toyoaki Murohara
出版者: The Japanese Circulation Society
雑誌: Circulation Journal (ISSN:13469843)
巻号頁・発行日: vol.83, no.10, pp.1980-1985, 2019-09-25 (Released:2019-09-25)
参考文献数: 75
被引用文献数: 172

Tobacco smoking continues to be a major risk factor for cardiovascular disease (CVD) and the leading avoidable cause of death worldwide. Tobacco smoking has declined in high-income countries, but the average smoking rate in Japan remains high: 29.4% for men and 7.2% for women in 2017. Of note, the average smoking rate among middle-aged men remains approximately 40%, indicating that a high incidence of smoking-related CVD will continue for a couple of decades in Japan. The adverse effects of tobacco smoking on CVD are more extensive than previously thought. Physicians should be particularly alert to the development and progression of heart failure, atrial fibrillation, and venous thromboembolism, as well as ischemic CVD among tobacco smokers. Increasing use of heat-not-burn tobacco as cigarette alternatives is an emerging issue. Harmful effects do not disappear just by changing the delivery system of tobacco.

2019-10-10 07:38:08
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3 0 0 0 OA Characterization of a Vitamin B12 Compound in the Edible Purple Laver, Porphyra yezoensis

著者: Fumio WATANABE Shigeo TAKENAKA Hiromi KATSURA Emi MIYAMOTO Katsuo ABE Yoshiyuki TAMURA Toshiyuki NAKATSUKA Yoshihisa NAKANO
出版者: (社)日本農芸化学会
雑誌: Bioscience, Biotechnology, and Biochemistry (ISSN:09168451)
巻号頁・発行日: vol.64, no.12, pp.2712-2715, 2000 (Released:2005-01-28)
参考文献数: 12
被引用文献数: 34

The edible purple laver, Porphyra yezoensis, contained 51.49±1.51 μg of vitamin B12 compounds per 100 g dry weight of the laver (mean±SEM, n=4). A vitamin B12 compound was purified from the lyophilized purple laver and partially characterized. The silica gel 60 TLC and reversed-phase HPLC patterns of the purified pink-colored compound were identical to those of authentic vitamin B12, but not to those of vitamin B12 analogues inactive for humans.

2019-02-15 04:14:23
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2 0 0 0 OA Association of Low-Density Lipoprotein Cholesterol with Risk of Coronary Heart Disease and Stroke among Middle-Aged Japanese Workers: An Analysis using Inverse Probability Weighting

著者: Abubakr Ahmed Abdullah Al-shoaibi Yuanying Li Zean Song Chifa Chiang Yoshihisa Hirakawa KM Saif-Ur-Rahman Masako Shimoda Yoshihisa Nakano Masaaki Matsunaga Atsuko Aoyama Koji Tamakoshi Atsuhiko Ota Hiroshi Yatsuya
出版者: Japan Atherosclerosis Society
雑誌: Journal of Atherosclerosis and Thrombosis (ISSN:13403478)
巻号頁・発行日: pp.63519, (Released:2022-07-13)
参考文献数: 48
被引用文献数: 4

Aims: The associations between low-density lipoprotein cholesterol (LDL-C) and the risk of cardiovascular disease (CVD) subtypes are not well established among the Japanese population. This study used longitudinal data from the Aichi Workers' Cohort Study to explore the association between LDL-C levels and the risk of coronary heart disease (CHD) and stroke subtypes. Methods: Pooled data of 8966 adults (7093men and 1903 women) who were recruited between (2002) and (2008) were used for the current analysis. Propensity scores for the LDL-C categories were generated using multinomial logistic regression. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated from the inverse probability weighted Cox proportional hazards model for LDL-C category associations with risks of CHD, stroke subtypes, and CVD. Results: During a median follow-up of 12 years, 122 strokes (57 ischemic strokes, 25 intracerebral hemorrhage, and 40 unknown subtypes) and 82 cases of CHD were observed. LDL-C 160- mg/dL compared to LDL-C 100-119 mg/dL was positively and significantly associated with the risk of CHD (HR: 4.56; 95% CI: 1.91-10.9) but not with ischemic stroke (HR: 0.99; 95% CI: 0.44-2.22). LDL-C was inversely associated with the risk of intracerebral hemorrhage (P for trend=0.009). Conclusion: In middle-aged Japanese workers, LDL-C was significantly and positively associated with CHD, but not with ischemic stroke. LDL-C was inversely significantly associated with intracerebral hemorrhage.

2022-07-14 15:54:04
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2 0 0 0 OA Goal-Oriented Sequential Combination Therapy Evaluated Using Cardiopulmonary Exercise Parameters for the Treatment of Newly Diagnosed Pulmonary Arterial Hypertension ― Goal-Oriented Therapy Evaluated by Cardiopulmonary Exercise Testing for Pulmonary Arterial Hypertension (GOOD EYE) ―

著者: Akihiro Hirashiki Takahisa Kondo Shiro Adachi Yoshihisa Nakano Yoshihiro Kamimura Shigetake Shimokata Naoki Okumura Atsuya Shimizu Yukihiko Washimi Hidenori Arai Toyoaki Murohara on behalf of the GOOD EYE Investigators
出版者: The Japanese Circulation Society
雑誌: Circulation Reports (ISSN:24340790)
巻号頁・発行日: vol.1, no.7, pp.303-311, 2019-07-10 (Released:2019-07-10)
参考文献数: 39
被引用文献数: 3

Background:Many treatment options are available for pulmonary arterial hypertension (PAH), but specific recommendations for long-term treatment are unavailable. We compared prognosis in PAH patients receiving goal-oriented, sequential combination therapy evaluated using cardiopulmonary exercise testing (CPX) parameters or conventional empiric therapy.Methods and Results:The Goal-Oriented Therapy Evaluated by Cardiopulmonary Exercise Testing for Pulmonary Arterial Hypertension (GOOD EYE) study was a multicenter, retrospective/prospective study in which a total of 129 patients with newly diagnosed PAH were enrolled (goal-oriented sequential combination therapy, n=42; conventional empiric therapy, n=87). Patients in the goal-oriented therapy group received sequential combination therapy, the efficacy of which was regularly evaluated using CPX parameters. Patients in the conventional empiric therapy group received conventional empiric therapy. The primary endpoint was cardiovascular death. In the goal-oriented therapy group, plasma brain natriuretic peptide, mean pulmonary arterial pressure, pulmonary vascular resistance, and 6-min walk test were significantly improved at 12 months compared with baseline. Survival in the goal-oriented therapy group at 1, 2, and 3 years (97.6%, 95.2%, and 86.0%, respectively) tended to be higher than that in the conventional empiric therapy group (P=0.082).Conclusions:Goal-oriented sequential combination therapy evaluated using CPX parameters may be associated with a favorable prognosis compared with conventional empiric therapy in patients with newly diagnosed PAH.

2019-07-10 08:16:15
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1 0 0 0 OA Implications of Pulmonary Artery Wave Reflection in Patients With Pulmonary Hypertension

著者: Yoshihisa Nakano Shiro Adachi
出版者: The Japanese Circulation Society
雑誌: Circulation Journal (ISSN:13469843)
巻号頁・発行日: pp.CJ-21-0981, (Released:2021-12-21)
参考文献数: 10

2021-12-21 13:42:01
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1 0 0 0 OA Risk of Pulmonary Arterial Hypertension During Qing-Dai Use for the Treatment of Ulcerative Colitis

著者: Shiro Adachi Yoshihisa Nakano Takahisa Kondo
出版者: The Japanese Circulation Society
雑誌: Circulation Journal (ISSN:13469843)
巻号頁・発行日: pp.CJ-20-0621, (Released:2020-07-11)
参考文献数: 12
被引用文献数: 4

2020-07-15 18:32:59
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1 0 0 0 OA Purification and Characterization of Corrinoid-Compounds from the Dried Powder of an Edible Cyanobacterium, Nostoc commune (Ishikurage)

著者: Fumio WATANABE Yuri TANIOKA Emi MIYAMOTO Tomoyuki FUJITA Hiroyuki TAKENAKA Yoshihisa NAKANO
出版者: Center for Academic Publications Japan
雑誌: Journal of Nutritional Science and Vitaminology (ISSN:03014800)
巻号頁・発行日: vol.53, no.2, pp.183-186, 2007 (Released:2008-01-10)
参考文献数: 19
被引用文献数: 15 19

Vitamin B12 content (98.8±5.6 μg/100 g dry weight) of an edible cyanobacterium, Nostoc commune (Ishikurage) was determined by the Lactobacillus delbrueckii ATCC 7830 microbiological method. Bioautography with vitamin B12-dependent Escherichia coli 215 indicated that N. commune contained two (main and minor) corrinoid-compounds. These corrinoid-compounds were purified to homogeneity from the dried algal cells and characterized. The main and minor purified corrinoid-compounds were identified as pseudovitamin B12 and vitamin B12, respectively, on the basis of silica gel 60 TLC, C18 reversed-phase HPLC, 1H NMR spectroscopy, and UV-visible spectroscopy. These results suggest that the bacterial cells are not suitable for use as a vitamin B12 source, especially in vegetarians.

2020-01-20 05:27:29
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1 0 0 0 OA Occurrence of Vitamin B12 in Green, Blue, Red, and Black Tea Leaves

著者: Hiromi KITTAKA-KATSURA Fumio WATANABE Yoshihisa NAKANO
出版者: Center for Academic Publications Japan
雑誌: Journal of Nutritional Science and Vitaminology (ISSN:03014800)
巻号頁・発行日: vol.50, no.6, pp.438-440, 2004 (Released:2009-04-28)
参考文献数: 7
被引用文献数: 8 11

Vitamin B12 contents of green (0046-0263 and 0, 125-0535μg/ 100g dry weight), blue (0.068-0.081 and 0.525-0.528μg/100g dry weight), red (0.061 and 0.663μg/100g dry weight), and black (0.104-0.859 and 0.305-1.20μg/100g dry weight) tea leaves were obtained by intrinsic factor-chemiluminescence and microbiological methods, respectively. Although vitamin Bit was found in all tea leaves tested by both assay methods, the higher values by the microbiological method were not due to occurrence of both deoxyribosides and deoxynucleotides (known as an alkali-resistant factor), but may have been due to that of inactive corrinoid compounds for mammals in the tea leaves.

2018-03-01 03:34:18
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