著者

福原 武

出版者

日本平滑筋学会

雑誌

日本平滑筋学会雑誌 (ISSN:03743527)

巻号頁・発行日

vol.5, no.1, pp.1-8, 1969-03-01 (Released:2010-07-21)

参考文献数

36

---

これまで消化管の自律神経支配については, 自律神経脱落現象腸外反射, 神経刺激効果および腸内反射効果をもとにして論じられてきたが, 各研究者の間には十分の意見の一致がみられなかった.著者は, 自身および協力者の研究結果からつぎに要約するような見解に到達した.1) 腸内反射の研究結果によると, 腸壁にはAuerbach神経叢中に亢進と抑制の両種神経細胞が存在し, 前者はコリン性であるが, 後者は非アドレナリン性であり, その伝達物質は未知である.2) 副交感神経線維には, 腸壁内に入って亢進細胞に連結するものと, 抑制細胞に連結するものとある.交感神経線維は, まず前脊稚神経節中でニューロンを交代した後, 亢進性のものは亢進細胞と連結し, 抑制性のものはアドレナリン性であって, そのまま筋に終る.3) 正常時においては, 腸-腸外反射の場合のように, 一般に副交感神経では亢進線維, 交感神経では抑制線維の興奮が優越するけれども, 腸のおかれる条件如何によっては, 壁内神経要素の興奮性に異変が起り, その結果として効果が逆転することもあり得る.4) 結局, これまでの研究成績の不一致は壁内神経要素の組織学的また生理学的複雑さと, これら要素の興奮性の不安定に帰因するものと考えられる.5) 上述の消化管の自律神経支配の特徴を考慮しながら, 消化管運動に関する薬物の作用機序究明のすすめ方に論及した.

著者

柳浦 才三 石川 滋 三沢 幸子

出版者

日本平滑筋学会

雑誌

日本平滑筋学会雑誌 (ISSN:03743527)

巻号頁・発行日

vol.10, no.2, pp.77-96, 1974-06-01 (Released:2010-07-21)

参考文献数

50

---

The present study was made to investigate in detail the mechanism of the bileflow into the duodenum in rabbit. The bile flow through the choledochoduodenaljunction was measured with a constant-rate infusion apparatus or with a constant-pressure perfusion apparatus. Pressures in gall-bladder, common bile duct and duodenum were recorded with pressure transducer. The electrical activities were recorded with bipolar electrodes which were implanted in the choledochoduodenal junction (muscle of Oddi) and the anterior wall of duodenum. The results obtained are as follows:1. The activity of choledochoduodenal junction appears to be affected by the change in duodenal wall muscle tone.2. The important factors controlling the bile flow are the rhtyhmic movements of both the choledochoduodenal junction and the duodenal wall.3. The common bile duct plays a role to regulate the pressure of biliary truct.4. Electrical and mechanical stimulations to gall-bladder were ineffective to cause the relaxing reflex of the muscle of Oddi.5. The function of gall-bladder is to accumulate the bile and control the pressure of common bile duct.From these results, it seems unlikely that the choledochoduodenal junction (muscle of Oddi) would be independent of duodenum in rabbit.

著者

福原 武 内藤 富夫 亀山 博子

出版者

日本平滑筋学会

雑誌

日本平滑筋学会雑誌 (ISSN:03743527)

巻号頁・発行日

vol.9, no.1, pp.1-8, 1973-03-01 (Released:2010-07-21)

参考文献数

13

被引用文献数

2 3

---

1.カエルの喉門・食道開口附近の粘膜を機械的に刺激すると, 腹筋が急に強縮をおこし, 口中に食道と胃が裏返しになって出てくる.この際胃の運動高進は, 認められない.この口中への胃の脱出の機序は, つぎのようなものであろう.まず腹筋の強縮によって, 腹圧が突然に高まり, その結果として胃が押しあげられ, ついに食道内に嵌入するのである.このことから, カエルにおいては, 嘔吐は胃の収縮によってではなく, 全く腹筋の収縮によって起こるものと考えられる.2.0.05g/mlの濃度を有する吐酒石-Ringer液の0.5ml (トノサマガエル) あるいは5ml (ウシガエル) を胃内腔に注入すると, 食道と胃の脱出ばかりでなく, 胃の運動の高進が起こる.脳脊髄破壊カエルでは食道・胃の脱出は起こらないが, 胃の運動高進効果は認められる.したがってこの高進効果は薬物が直接胃壁に作用してひき起こされたものと考えられる.

著者

寿田 鳳輔 藤井 久四郎 新井 和夫 丸岡 利市 斎藤 仁隆

出版者

Japan Society of Smooth Muscle Research

雑誌

日本平滑筋学会雑誌 (ISSN:03743527)

巻号頁・発行日

vol.4, no.2, pp.191-202, 1968

---

The spontaneous and oxytocin induced electrical activity of the pregnant uterus of rat has been studied <I>in vivo</I> by recording electromygorams at various stages during pregnancy. The electrical activity has been compared at different uterine portions in the pregnant uterus of rat; at the myometrium of the corpus, the cervix, the edge of the placental area, and the placental area. Also, one or two electrodes (silver wire, 50μ in diameter) were introduced into the myometrial coat at the different uterine poitions for the recording as described in the previous report. The experiments were performed on the 12th, 13th, 14th, 18th and 21st days of pregnancy. The electrical activity of the pregnant rat uterus consisted of repetitive spike discharges at the different uterine portions through various stages of pregnancy. <I>In vivo</I>, myometrium of the placental area showed a little spontaneous activity before term, but there was no difference between the myometrium of the edge of the placental area and of the other portions (the corpus and the cervix). No distinction between the electrical excitability of placental and nonplacental myometrium was observed at term. After the above control records were taken, oxytocin was injected in a dose of 2 or 3 i.u. intraumuscularly and the response in increase of spike discharges at the different uterine portions were clearly detected.

著者

北村 温

出版者

日本平滑筋学会

雑誌

日本平滑筋学会雑誌 (ISSN:03743527)

巻号頁・発行日

vol.11, no.1, pp.15-20, 1975-03-01 (Released:2010-07-21)

参考文献数

13

---

The author developed a new electromyography of the detrusor muscle which is applicable also for clinical examinations and obtained the following results:1. In the normal bladder no action potential appeared when the organ was not full yet.2. When the intravesical pressure was raised by introducing saline into trie bladder, spikes appeared.3. Spikes of high frequency appeared with the onset of voiding.4. In the normal bladder no action potential appeared by administration of 5 to 7 mg mecholyl.5. From some muscles of the dome of the bladder was obtained spontaneous spike potential consisting of spike burst of about 10 spikes. In an animal experiment using adult dogs the spikes of the simple type appeared. The discharge interval was about 5 seconds.6. In the bladder with damaged peripheral nerve, spikes appeared during veridical quiescence.7. In the bladder with damaged peripheral nerve, spikes of high frequency appeared by administration of 5 to 7 mg mecholyl.

著者

ファラマル アシュリー 日高 弘義 高井 章 富田 忠雄

出版者

Japan Society of Smooth Muscle Research

雑誌

日本平滑筋学会雑誌 (ISSN:03743527)

巻号頁・発行日

vol.21, no.1, pp.57-69, 1985

被引用文献数

4

---

Aschoori, F., Hidaka, H., Takai, A. & Tomita, T. <I>Contraction of smooth muscle in Ca-free solution</I>. Japanese Journal of Smooth Muscle Research, 1985, 21 (1), 57-69.-The tonic contractions which are extremely resistant to removal of the external Ca were investigated in the rat was deferens and myometrium. Both the noradrenaline response in the was deferens and the oxytocin response in the myometrium could be repeatedly produced without appreciable diminution in Ca-free solution for more than 24hrs. On the other hand, the tissue Ca content decreased exponentially after Ca-removal with a half time of 130-180min. When Ca was readmitted, no indication of the early transient contraction was observed in the subsequent response in Ca-free solution, but the response was reduced compared with the response before Ca readmission. Verapamil suppressed the response in the presence of Ca, while it had very weak inhibitory effect even at 10μM. Calmodulin antagonists of phenothi-azine derivatives had a strong inhibitory effect on Ca-induced contractions, whereas they had very weak effects on the receptor-mediated contraction in Ca-free solution. Another calmodulin antagonist, W-7 suppressed both Ca-induced contraction and the contractions independent of external Ca. HA-1004, a vasodilator which has a struc-ture similar to W-7, reduced the receptor-mediated contraction in Ca-free solution without much effect on Ca-induced contractions. These results may suggest that the receptor-mediated contractions resistant to Ca-removal are caused by some process without a contribution of the Ca-calmodulin system.

著者

寿田 鳳輔 藤井 久四郎 新井 和夫 丸岡 利市 斎藤 仁隆

出版者

Japan Society of Smooth Muscle Research

雑誌

日本平滑筋学会雑誌 (ISSN:03743527)

巻号頁・発行日

vol.4, no.1, pp.37-45, 1968

---

Albino rats of Wistar strain with normal sexual cycle on the basis of their vaginal smears were used and anesthetized with Mintal (pentobarbital) injecting 5 mg/100 g intraperitoneally in acute experiments. Spontaneous electromyographic activity of the rat uterus <I>in vivo</I> was recorded using a concentric electrode (silver wire, 50μ diameter). One electrode was placed in the tubal side and the other electrode in the cervical side of a corpusuteri of the rat. Electromyographic recordings were made with a 2 channel inkwritingapparatus. The spontaneous electrical activity of the rat uterus <I>in situ</I> could be observed through the cycle. The basic electromyographic patterns of the nonpregnant ratuterus at the estrus were the train of spike and the spike burst. From proestrus to estrus, the spontaneous spike discharges increased in amplitude and in frequency and became of a set of their discharges. In some cases the spontaneous spike discharges were observed sporadically at the diestrus of the cycle and the castrated condition.

著者

中村 紀夫

出版者

日本平滑筋学会

雑誌

日本平滑筋学会雑誌 (ISSN:03743527)

巻号頁・発行日

vol.6, no.4, pp.245-262, 1970-12-20 (Released:2010-07-21)

参考文献数

9

---

This study presents a new technique to observe the structure of gastric smooth muscle layers by means of the combined use of “mucosa stripping technique” and “nitric acid treatment”. The mucosa stripping technique has been described elsewhere. After the procedure, the specimens are re-emersed into 20% nitric acid solution for 3 to 7 days. By the time, the muscle fibers contract tightly and the interstitial fibrous tissues become swollen and fragil, and they are easily removed by forceps in running water. Leaving muscle structure is solidly delineated.By this method, the author explored the detailed structure of three layers of gastric smooth muscles and individualized the special muscle bundles; namely, “anterior medial oblique muscle bundle”, “posterior medial oblique muscle bundle” and “border circular muscle bundle”. These muscle bundles constitute, so-called, “upper strain zone” in relation to the development of peptic ulcers at about the gastric angulus where almost all uclers locate.Special interest is emphasized on an existence of “lesser curvature longitudinal muscle bundle” which is confined to the area of upper strain zone and tapering off in gradual fusion with the circular muscle bundles. Although, the functional signfiicance of these muscle bundles remains for the future study.

著者

田中 丈二

出版者

日本平滑筋学会

雑誌

日本平滑筋学会雑誌 (ISSN:03743527)

巻号頁・発行日

vol.1, no.1, pp.50-71, 1965-08-05 (Released:2010-07-21)

参考文献数

62

被引用文献数

2

---

Rabitts were used in these experiments. The spike potentials of the duodenum and choledocho-duodenal junction, the pressure in the common bile duct and the discharge of bile into the duodenum were recorded simultaneously in vivo.In the duodenum and the choledocho-duodenal junction, the rate of the rhythmic burst of spike potentials was 12-16 cycles/min.Similar results were obtained in both regions by the administrations of acetylcholine, prostigmine, bethanechol chloride, pilocarpine, atropine, adrenaline, morphine, cholecystokinin, secretin and amyl-nitrite. Thus, the action of the choledocho-duodenal junction is not independent of that of the duodenum.The pressure in the common bile duct rises simultaneously with the appearance of the spike potentials of the choledocho-duodenal junction.The discharge of bile into the duodenum was prevented by the muscle contraction of the choledocho-duodenal junction, when the bursts of spike potentials appeared. Bile was discharged into the duodenum by relaxation of the choledochoduodenal junction. When the pressure in the common bile duct was kept constant at about 80mm H2O, the discharge of bile into the duodenum was increased by the administration of C. C. K. during the resting intervals of the remarkable bursts of spike potentials.