著者

塩 宏

出版者

一般社団法人 日本痛風・核酸代謝学会

雑誌

尿酸 (ISSN:03884120)

巻号頁・発行日

vol.6, no.1, pp.55-60, 1982 (Released:2012-11-27)

参考文献数

6

被引用文献数

1

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Serum uric acid levels were determined in 10 patients with hypothyroidism and the following results were obtained. 1. Hyperuricemia was found 1 of 2 in male and 2 of 8 in female. 2. There was the tendency to show the higher values of serum uric acid in untreated hypothyroid patients compared to control group. 3. Hype ruricemia in women was after menopause. 4. The average decrement of serum uric acid concentration in 10patients after the thyroid treatment was 1.4 mg/100ml. 5. Hypothyroid patients showed a tendency of decreased urinary excretion of urate and unstable uric acid clearance. 6. The almost parallel decrease between uric acid and cholesterol, TSH was found after the treatment of thyroid.

著者

伊藤 朗 三上 俊夫 丹 信介 後藤 浩史 井川 幸雄

出版者

一般社団法人 日本痛風・核酸代謝学会

雑誌

尿酸 (ISSN:03884120)

巻号頁・発行日

vol.8, no.1, pp.38-47, 1984 (Released:2012-11-27)

参考文献数

14

被引用文献数

3

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The study was investigated effects of different kinds of exercise on serum uric acid as the basic research data for preventing athletes and non-athletes from exercised-induced hyperuricemia and carring out exercise treatment for hyperuricemia. The results were summarized as follows: 1) Changes in serum uric acid on different kinds of exercise: On an exhaustive exercise on a bicycle ergometer for 5-10 min, serum uric acid was gradually increased, and reached a peak at 2 hrs after exercise. And then it was gradually decreased until 24 hrs after exercise, but was significantly 9.9% higher at 24 hrs after exercise than before exercise (p<0.001). On a 12 min-run, serum uric acid reached a peak immediatly after ex ercise, and then kept the same level until 2 hrs after exercise. On a 2 hrs running on a treadmill, serum uric acid showed a linear increase, and reached a peak at 45 min during exercise. And then it was the same level until 90 min after exercise. 2) Comparison of the degree of increase in serum uric acid on different kinds of exercise: The degree of increase in serum uric acid against before exercise was the largest (+87.9%, p<0.001) on an exhaustive exercise on a bicycle ergometer in untrained subjects, and was with a range of +9.0 to +34.2% on a 12-min -run, a 2 hrs running on a treadmill and so on. 3) Relationship between exercise in t e nsity and increase inserum uric acid when the amount of exercise was the same: The increase in serum uric acid after exercise was proportional to exercise intensity on 60%, 80%, and 100% V02 max. But serum uric acid was almost unchanged after 40% V02 max exercise, and tended to be decreased after 30% V02 max exercise. 4) The ratio of appearence of exercise-induced hyperuricophenomenon (phenomenon of a temporary high level of serum uric acid over 7 mg/dl after severe exercise): The ratio of appearence of exercise-induced hyperurico-phenomenon was 38.1% (75 out of 197 untrained subjects) at 5,000m run, and 53.3% (16 out of 30 trained subjects) at 12-min-run. 5) Effects of training on the degree of increase in serum uric acid after exercise: After training of walking and jogging for 4 months, the mean distance of 12-min-run was increased (2,444m→2,611m), but the degree of increase in serum uric acid after 12mm-run was decreased (+18.3%→+9.1%) in contrast to before training.

著者

門田 一郎 田中 研一 服部 雅康

出版者

一般社団法人 日本痛風・核酸代謝学会

雑誌

尿酸 (ISSN:03884120)

巻号頁・発行日

vol.3, no.1, pp.62-70, 1979 (Released:2012-11-27)

参考文献数

21

著者

井奈波 良一 中村 秀喜 古野 利夫 有泉 誠

出版者

一般社団法人 日本痛風・核酸代謝学会

雑誌

尿酸 (ISSN:03884120)

巻号頁・発行日

vol.8, no.2, pp.165-167, 1984 (Released:2012-11-27)

参考文献数

8

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We measured the levels of serum uric acid and serum lipid peroxides generated by oxygen radicals in 19 healthy young males.There were no significant correlations between serum uric acid levels and body weights, nor between serum blood urea nitrogen levels and serum creatinine levels. However, there was a significant correlation between serum uric acid levels and serum lipid peroxides levels. As uric acid is thought to be an important scavenger of singlet oxygen and radicals, these results suggests that serum uric acid competes with the increase of serum lipid peroxides.

著者

伊藤 朗 古賀 由香 秦野 伸二 三上 俊夫 村上 秀明 後藤 浩史 丹 信介

出版者

一般社団法人 日本痛風・核酸代謝学会

雑誌

尿酸 (ISSN:03884120)

巻号頁・発行日

vol.10, no.2, pp.65-74, 1986 (Released:2012-11-27)

参考文献数

21

被引用文献数

2

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各種スポーツマン, すなわち陸上競技の投てき(以後投てきと略),同短距離(以後短距離と略),同跳躍(以後跳躍と略),同長距離(以後長距離と略),器械体操,水球,水泳,ラグビー・フォワード( 以後フォワードと略) , 同バックス(以後バックスと略),野球,ハンドボール(以後ハンドと略),バレーボール(以後バレーと略),バスケットボール(以後バスケと略),サッカー,弓道,スキー,テニス,柔道,モトクロスの尿酸代謝について検討した.被検者は,18-29歳の男性211名とした.結果は以下のとおりである.1)全員の血清尿酸値(以後SUAと略)は,正規分布を示し,平均値は5.95mg/dl,2 S.D.は3.07-8.83mg/dlであった.種目別のSUAは高値順から投てき,水球,野球と続き,低値順からはモトクロス,跳躍,バレーと続いた.2)全員の高尿酸血症(7,5mg/dl以上)発症率(以後発症率と略)は9.95%,種目別発症率は,高率順から投てき,野球(各25%),テニス(20%)と続き,モトクロス,弓道,スキーなど7種目は発症しなかった.3)全員の尿中尿酸排泄量は,正規分布を示し,平均値は692mg/day,2S.D.は220-1,161mg/dayであった.種目別では,高値順から野球,柔道,バックスと続き,低値順からは器械体操,水泳,弓道と続いた.4)全員の尿酸クリァランス(以後CUAと略)は,対数正規分布を示し,平均値は7.87ml/min,2S.D.は3.35-18.49ml/minであり,種目別では高値順から長距離,バレー,バックスと続き,低値順からは器械体操,サッカー,テニスと続いた.5)全員のSUAとCUAには相関が認められ,相関係数は- 0.523 (p<0.001) であった.以上の結果および各種目の運動特性を考慮すると以下の示唆が得られた.1)アマの一流でない一般のスポーツマンのSUAは,一般人の平均値より高値が13種目,低値が6 種目, また発症率が一般人より高率が7種目,同率5種目,低率7種目であり種目間の差が著しく,なかには運動の影響のみられない種目があることが示唆された.本対象のSUA,発症率は最高でもプロ,アマー流選手より低く,活躍度が関係していることが示唆された.2)各種目の運動特性と尿酸代謝の関係は,パワー,有気的持久性,無気的持久性が多く含まれている種目の影響が大きく,なかでもパワーの影響が大きい.またパワー,有気的持久性が多く含まれ,無気的持久性の少ない種目は,尿酸産生過剰型であることが示唆された.一方,無気的持久性が多く含まれる種目は,尿酸排泄低下型であるが,パワー,有気的持久性の要素も含まれる種目では産生過剰の両型あることが示唆された.

著者

清水 徹 西川 美年子 八谷 孝 甲斐 敏晴

出版者

一般社団法人 日本痛風・核酸代謝学会

雑誌

尿酸 (ISSN:03884120)

巻号頁・発行日

vol.5, no.1, pp.50-61, 1982 (Released:2012-11-27)

参考文献数

12

被引用文献数

1

著者

Aoki Tsugutoshi Arima Masataka

出版者

Japanese Society of Gout and Nucleic Acid Metabolism

雑誌

尿酸 (ISSN:03884120)

巻号頁・発行日

vol.1, no.1, pp.35-41, 1977

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Measurement was made of HGPRT and APRT activities in erythrocytes for 15 cases of Lesch-Nyhan syndrome. As for the activity of HGPRT in 2 cases with Lesch-Nyhan syndrome, there appeared the enzyme activity when the substrates, concentrations of hypoxanthine and PRPP, were made to rise. The activity of HGPRT in erythrocytes of two cases at high concentration of hy poxanthine rose in a sigmoid curve when the concentration of PRPP was made to rise, whereupon the apparent Km stood at 9.2×10<SUP>-3</SUP> and 9.8×10<SUP>-3</SUP>. This apparent Km was about 30 times that of the control group. The Km to hypoxanthine was 1.8×10<SUP>-4</SUP> in both cases, which was about 10 times that of the control group. The activity of HGPRT in erythrocytes of other 13 cases showed no change.<BR>In 1970, Seegmiller et al. provided deficiency of HGPRT activity in erythrocytes of patients with Lesch-Nyhan syndrome (1).<BR>In 1971, Arnold et al. (2) and Rubin et al. (3) purified HGPRT enzyme protein in erythrocytes of normal adult males and prepared anti-HGPRT serum using rats or rabbits. It was made clear that HGPRT enzyme protein is present in erythrocytes of patients with Lesch-Nyhan syndrome since these erythrocytes al beit without enzyme activity, showed an absorption band to anti-HGPRT serum serum immunologically. HGPRT protein in erythrocytes of patients with Lesch-Nyhan syndrome was reported to be 140μg/ml erythrocytes, an amount equal to that in normal adult males (4,5).<BR>Recently, McDonald et al. (6) have reported a variant type of erythrocyte HGPRT enzyme in one case of Lesch-Nyhan syndrome. This is of great interest since there have been previous reports merely on cases in which the enzyme activity was defect in this syndrome.<BR>We have made measurement of erythrocytes HGPRT and APRT enzyme activities in 15 cases of Lesch-Nyhan syndrome. In two cases, a rise in HGPRT activity was demonstrated for variations in concentrations of hypoxanthine and PRPP, the substrates.<BR>In this paper mention will be made of the enzymatic study on erythrocytes HGPRT and APRT activities referring to these two cases.

著者

影山 信雄

出版者

一般社団法人 日本痛風・核酸代謝学会

雑誌

尿酸 (ISSN:03884120)

巻号頁・発行日

vol.7, no.2, pp.225-234, 1983 (Released:2012-11-27)

参考文献数

5