著者

梶谷 文彦 友永 轟

出版者

一般社団法人 日本生体医工学会

雑誌

医用電子と生体工学 (ISSN:00213292)

巻号頁・発行日

vol.21, no.3, pp.145-150, 1983-06-30 (Released:2011-10-14)

参考文献数

32

被引用文献数

1

著者

林田 健男 上野 武

出版者

一般社団法人 日本生体医工学会

雑誌

医用電子と生体工学 (ISSN:00213292)

巻号頁・発行日

vol.6, no.6, pp.441-448, 1968-12-15 (Released:2011-07-05)

参考文献数

51

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The progress in the field of organ transplantation and artificial organ has been remarkable in the recent years. The number of clinical cases is increasing daily, and the clinical renal transplantation will soon be performed in more than 2000 occasions. One human life has been supported by artificial kidneys for over eight years. Many hearts and livers have been transplanted, and artificial auxiliary left ventricles have been functioning in human bodies. The ancient dream of replacement of organs has almost been realized.In reviewing the history of development of organ substitutes, the current status in reference to various organs has been described as precisely as possible, along with the expected development and problems in the future.

著者

河田 亮 宮内 章光 高垣 裕子

出版者

一般社団法人 日本生体医工学会

雑誌

医用電子と生体工学 (ISSN:00213292)

巻号頁・発行日

vol.36, no.3, pp.252-258, 1998 (Released:2011-10-14)

参考文献数

34

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Osteocytes, dendritic resident cells in bone, transduce signals of mechanical loading that results in anabolic responses of bone. In our previous report with primary osteocytes derived from newborn rat calvaria, we showed that cAMP levels were elevated 15min after the initiation of streching, and that the protein levels of both IGF-I and osteocalcin were elevated 36h later. Here we report that stretching induces the expression of an immediate early gene, cfos, at 15min and of osteocalcin in several hours in these cells. Furthermore, the blockers of stretch activated channels and epithelial-like sodium channels, in combination, abolish the effects of stretching; elevated expression of osteocalcin and calcium influx into the stretched cells. Independent experiment with a blocker of L type channels also inhibited the osteocalcin expression caused by stretching. Therefore, it is conceivable that the calcium influxes, both primary and secondary, are the essential responses of stretched osteocytes that result in the anabolic reaction of bone.

著者

橋本 謙

出版者

一般社団法人 日本生体医工学会

雑誌

医用電子と生体工学 (ISSN:00213292)

巻号頁・発行日

vol.10, no.3, pp.207-216, 1972-06-30 (Released:2011-03-09)

参考文献数

25

著者

上松 弘明 森 博愛

出版者

一般社団法人 日本生体医工学会

雑誌

医用電子と生体工学 (ISSN:00213292)

巻号頁・発行日

vol.11, no.2, pp.78-85, 1973-04-30 (Released:2011-07-05)

参考文献数

8

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Validity of Fourier coefficients as parameters for the electrocardiographic pattern recognition by means of the threshold logic units and the maximum likelihood method was verified. As the traditional methods of Fourier transform required much time, a new method of fast Fourier transform of folding type, which differed from FFT of Cooley and Tukey, was developed. Sampling points used in the present investigations totaled 100. Using scalar ECG of Frank's orthogonal system (X, Y and Z leads) 15 normal subjects, myocardial infarction cases and ostium secundum type of atrial septal defect cases respectively were analyzed by this new method, and the coefficients such as An, Bn, √An2+Bn2 and Arctan (An/Bn) were obtained.√An2+Bn2 was considered as the most useful parameter among them, because it is invariant for the parallel shift of amplitude and time axis.Normals, myocardial infarction and atrial septal defect cases were classified, in 100 per cent success, by threshold logic units and maximum likelihood method in the twelve dimensional information space, respectively using the initial four Fourier coefficients of the X, Y and Z leads as parameters.Fourier coefficient parameters were estimated by t-tests, and then the effort was made to reduce the numbers of parameters of information space.Complete separation was also obtained even when the number of dimension were reduced to seven by using the initial seven Fourier coefficients of X lead alone. This suggested that the important diagnostic information was mostly contained in X lead, and also that the lower harmonic components had the greater part of the information of ECG. Nonlinear discriminant function played an important role in the low dimensional information space.

著者

角田 忠信

出版者

一般社団法人 日本生体医工学会

雑誌

医用電子と生体工学 (ISSN:00213292)

巻号頁・発行日

vol.21, no.6, pp.426-432, 1983-10-30 (Released:2011-10-14)

参考文献数

16

著者

浅井 潔

出版者

一般社団法人 日本生体医工学会

雑誌

医用電子と生体工学 (ISSN:00213292)

巻号頁・発行日

vol.40, no.Supplement2, pp.23, 2002 (Released:2011-10-14)

著者

小杉 幸夫 高倉 公朋 黄 明聰 岡部 隆博

出版者

一般社団法人 日本生体医工学会

雑誌

医用電子と生体工学 (ISSN:00213292)

巻号頁・発行日

vol.11, no.2, pp.86-93, 1973-04-30 (Released:2011-07-05)

参考文献数

11

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For successful operation of brain tumors, it is essential to minimize hemorrhage during neurosurgical operation, and to destroy any adjacent tumor cells. A newly developed technique for coagulating brain tumors as an operative procedure by using microwave was investigated. It penetrates a distance and destroys the tumor tissue with its thermal effect.For successful tissue coagulation, it is required to concentrate microwave energy to a narrow region. For this purpose, a kind of antenna was contrived and the thermal distribution in the vicinity of the antenna was investigated both theoretically and experimentally. It revealed that the near-by field of the antenna could make an adequate thermal distribution for local tissue coagulation. An experimental equipment was made for 2.45 GHz using magnetron as the microwave source.The desirable local coagulation on a dog's brain tissue was achieved with this experimental equipment. This method of local coagulation by microwave will facilitate more effective operation on tumors without unnecessary bleeding and scattering of tumor cells and will destroy as much tumor tissues as possible This method of tissue coagulation is considered applicable to treating not only brain tumors but also many other tumors and diseases.

出版者

一般社団法人 日本生体医工学会

雑誌

医用電子と生体工学 (ISSN:00213292)

巻号頁・発行日

vol.37, no.Supplement, pp.21-26, 1999-04-21 (Released:2011-10-14)

著者

青柳 卓雄 岸 道男 山口 一夫 渡辺 真一

出版者

一般社団法人 日本生体医工学会

雑誌

医用電子と生体工学 (ISSN:00213292)

巻号頁・発行日

vol.12, pp.90-91, 1974

著者

青柳 卓雄 岸 道男 山口 一夫 渡辺 真一

出版者

一般社団法人 日本生体医工学会

雑誌

医用電子と生体工学 (ISSN:00213292)

巻号頁・発行日

vol.12, no.Suppl, pp.90-91, 1974-03-30 (Released:2011-06-02)

被引用文献数

1

出版者

一般社団法人 日本生体医工学会

雑誌

医用電子と生体工学 (ISSN:00213292)

巻号頁・発行日

vol.33, no.Supplement, pp.301-306, 1995-05-01 (Released:2011-10-14)

出版者

一般社団法人 日本生体医工学会

雑誌

医用電子と生体工学 (ISSN:00213292)

巻号頁・発行日

vol.12, no.Special, pp.12-15, 1974-09-30 (Released:2011-03-09)

著者

吉田 文武

出版者

一般社団法人 日本生体医工学会

雑誌

医用電子と生体工学 (ISSN:00213292)

巻号頁・発行日

vol.21, no.5, pp.324-327, 1983-09-30 (Released:2011-10-14)

参考文献数

4

著者

井上 昌次郎

出版者

一般社団法人 日本生体医工学会

雑誌

医用電子と生体工学 (ISSN:00213292)

巻号頁・発行日

vol.12, no.2, pp.45-51, 1974-04-30 (Released:2011-03-09)

参考文献数

11

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An attempt to know the principle of control in the living systems by investigators in broad fields of nonbiological disciplines may give rise to the following expectation. The present-day technological civilization has urged every unit component and every unit process of our society to organize into certain purpose-pursuing systems, which have never existed before. Such huge artificial systems have brought about a tremendous development on one hand, but an unexpected transitional chaos on the other, which covers a world-wide range of disturbances to the harmony in our biosphere. Meanwhile, a biological organism exists as a totality, exhibiting a beautiful harmony not only with other external components but also with its own internal components. Consequently, the control principle governing the biological systems may give some valuable suggestions for the construction and well maintenance of artificial systems, through reorganizing our view of value. On the basis of such presupposition, discussions extend to how we can categorize living organisms into systems from phylogenetical, ontogenetical, distributional, morphological, biochemical, physiological, behavioral standpoints and so forth, referring to the integrative role played by the neuroendocrine control system. Then some characteristics of biological systems such as the a posteriori nature which is related to adaptability, individuality and feedback mechanism, the reproductivity and reutility associated with chain-relations and cyclicity, the variety and individual differences, and the incompleteness and nonlinearity related to dynamic stability, are described in comparison with artificial systems. The methodology applied to the analysis and synthesis of biological performances are also briefly reviewed. Finally, the difference between the status of our-recognition and the initial expectation is clarified together with some optimistic encouragement based on an analogy with evolutional history of the living organisms.

著者

小川 誠二

出版者

一般社団法人 日本生体医工学会

雑誌

医用電子と生体工学 (ISSN:00213292)

巻号頁・発行日

vol.38, pp.3, 2000

著者

大河原 章

出版者

一般社団法人 日本生体医工学会

雑誌

医用電子と生体工学 (ISSN:00213292)

巻号頁・発行日

vol.21, no.1, pp.2-8, 1983-02-28 (Released:2011-10-14)

参考文献数

3

被引用文献数

1

出版者

一般社団法人 日本生体医工学会

雑誌

医用電子と生体工学 (ISSN:00213292)

巻号頁・発行日

vol.30, no.Supplement, pp.157-163, 1992-05-01 (Released:2011-10-14)

著者

南谷 晴之 萩田 紀博

出版者

一般社団法人 日本生体医工学会

雑誌

医用電子と生体工学 (ISSN:00213292)

巻号頁・発行日

vol.18, no.4, pp.256-263, 1980-08-30 (Released:2011-03-09)

参考文献数

31

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In this study, a neural network model is proposed to obtain -the numerical description of pain mechanisms. The model simulates peripheral receptors, afferent L- and S-fibers and the receptive cells of the spinal cord area Adaptation effect and conduction velocity of each fiber are considered in the model. The activities of peripheral and spinal cord neural cells are represented by the Wilson-Cowan's differential equation, considering the ongoing activity of neurons. Pain and touch sensibilities are estimated by the firing activities of lamina V (Transmission, T) cells and lamina IV cells, respectively.The results of model simulation have been obtained for single square-wave pulse and periodic pulse sequences applied on peripheral receptors. The duration of initial bursts of T and IV cells, which occur soon after the beginning of stimulation, depends on the stimulus intensity and approaches a plateau with increasing intensity. In case the stimulus intensity is increased above the threshold of S-fibers, secondary burst of T cells appears about 50 msec after the stimulation, which is equivalent to the conduction time of S-fibers from the periphery towards the spinal cord cells. High-frequency and high-intensity stimulation gives the typical firing patterns of pain modality, represented by the high secondary burst of T cells which continues during the stimulation. From the results of periodic pulse stimulation, the so-called pain and absolute threshold characteristics have been obtained and have been compared with the results of cutaneous electrical stimulation. Both results are shown by quite a similar relationship between stimulus pulse frequency and stimulus intensity and their characteristics are given by the power function's law of frequency and intensity.The proposed neural network model mimics the pain modality very well, and the results of simulation are in good agreement with some of physiological and experimental results.

著者

山越 憲一 戸川 達男 神谷 瞭 藤井 禎三 土屋 喜一

出版者

一般社団法人 日本生体医工学会

雑誌

医用電子と生体工学 (ISSN:00213292)

巻号頁・発行日

vol.14, no.4, pp.296-302, 1976-08-30 (Released:2011-03-09)

参考文献数

9

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From the point of the optimal theory, the relationship between the branching structure and the mechanical characteristics of a tree was analysed in reference with such parameters as circum-ference, weight, bending moment, branch length and-branching angle, The study was based on a hypothesis that the optimal structure of a tree agrees the minimum energy loss.The total energy loss is the sum of the energy required for the construction which is proportional to the wood' volume of the branches and the energy consumption for supporting the weight of the branches and leaves which is equal to the elastic. strain energy. Results derived theoretically from the hypothesis are as follows : 1) The Maximum bending stress at each branching point is constant.2) The relation between the circurmference (C) at some point and the bending moment (T) acting on the branch is, T∝C3. 3) The relation between the weight (W) of all the parts of the tree peripheral to some branching point and C is, W∝C2.5. 4) The relation between T and W is, W∝T5/6. 5) The relatlon between the branch length (l) and C is, l2 ∝C. 6) When C0, C1, C2 are the circumferences of the mother and daughter branches and θ1, θ2 are their branching angles, the following optimal conditions for a dichotomy are derived;C02.5= C12.5+C22.5 and C13/ sinθ2=C23/ sinθ1.These relations were examined, by measuring the varying size of branches, 76-286 in all, on seven different kinds of trees, and the very good agreements between the theoreiical and actual relations were confirmed.