著者

小川 誠二

出版者

一般社団法人 日本脳卒中学会

雑誌

脳卒中 (ISSN:09120726)

巻号頁・発行日

vol.17, no.6, pp.489-496, 1995

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Functional MRI of the brain is briefly reviewed. The two methods used in fMRI to capture hemodynamic changes induced by brain activation are described. One is to measure regional CBF change by the inflow signal for a single slice image and the other is to acquire BOLD images where the image contrast is generated by the magnetic susceptibility of red cells containing paramagnetic deoxyhemoglobin. With these types of measurements, many images are taken rapidly in time sequence at a constant image acquisition mode and thus one can follow the brain activation in real time. Various early applications of fMRI to sensory stimulations, motor responses and some of cognitive functions are described and the potentials of fMRI are discussed. The feasibility of fMRI to use in stroke field is high and the merit of the method is expected to be extremely useful in the field.

著者

小川 誠二

出版者

公益社団法人 応用物理学会

雑誌

応用物理 (ISSN:03698009)

巻号頁・発行日

vol.42, no.3, pp.214-225, 1973

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Recent development in the application of magnetic resonance to biological systems is briefly reviewed. The magnetic resonance methods including high resolution NMR, pulse NMR and spin label EPR are described in terms of their merits and limitations in biological application. Recent interesting studies on biological macromolecules by magnetic resonance are explained in three sections : protein, nucleic acid and biological membrane. The covered topics in the protein section are histidine titration in RNase, various approaches taken for studying lysozyme, the heme-heme interaction in ;hemoglobin, oxidation-reduction in cytochrome c and few others. Paramagnetic relaxation enhancement method applied to the studies of the active sites of enzymes is also mentioned. In the nucleic acid section only tRNA studies are briefly described. The topics mentioned in the biological membrane section are molecular motions in phospholipid bilayers.

著者

小川 誠二

出版者

国立科学博物館

雑誌

ミルシル (ISSN:18825745)

巻号頁・発行日

vol.3, no.4, pp.3-5, 2010-07

著者

小川 誠二 成 烈完 神波 雅之

出版者

医学書院

雑誌

神経研究の進歩 (ISSN:00018724)

巻号頁・発行日

vol.47, no.6, pp.902-908, 2003-12

著者

小川 誠二

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.40, 2000

著者

小川 誠二

出版者

一般社団法人 日本生体医工学会

雑誌

医用電子と生体工学 (ISSN:00213292)

巻号頁・発行日

vol.38, pp.3, 2000

著者

小川 誠二

出版者

一般社団法人 日本生物物理学会

雑誌

生物物理 (ISSN:05824052)

巻号頁・発行日

vol.14, no.5, pp.183-199, 1974

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Nuclear magnetic resonance studies on the cooperative oxygen binding in hemoglobin are reviewed. First brief descriptions of NMR methods of variousl nuclei are made by typical examples found in hemoglobin studies. Then the recent interests in hemoglobin are categorized in four chapters, the allosteric transition between the two states with different functional properties, the presence of hemoglobin molecules with intermediate structure, α-β nonequivalency and the location of the interaction energy. Those topics are discussed mainly with NMR results in order to show the merit and limitation of the technique.