文献一覧: 岡山医学会 (出版者)

1 0 0 0 高温湿環境下,重筋労働に関する衛生学的研究:第2編高温,高湿環境下労働時の生理的許容限界ならびに休憩について

著者: 康逸雄
出版者: 岡山医学会
雑誌: 岡山医学会雑誌 (ISSN:00301558)
巻号頁・発行日: vol.78, no.1, pp.159-170, 1966

In this experiment, the author investigated the changes of blood and urine of the rescue team workers engaging in heavy tasks in high thermal conditions, in addition to the reaffirmation of the previous results. Further, he encountered several cases of heat stroke occasionally. The followings were the results obtained: 1. Change of pulse pressure which the results were obtained previously was affirmed statistically by increasing the number of the cases. 2. The cases of heat stroke suggested that the threshold limit of the increase of pulse pressure seemed to exist around the rate of 150%. 3. The threshold limit of body temperature (under tongue) was around 39°C. 4. By remarkable sweating after the task, blood was concentrated, resulting the increase of specific gravity of the total blood, proteine in plasma, hematocrit value and hemoglobin content. 5. The group of heat stroke showed higher pulse pressure, higher pulse rate, higher temperature under the tongue and has a tendency of a higher rate of blood concentration. 6. Life-saving mask type 4 produced heat when soda lime absorbed CO2 expired in the circulaing air. But the influence of the high temperature and high humidity of the environment was greater than the heated air-input of the mask. 7. The limitation of the continuity of the task in such a high thermal condition seemed to be around 30 minutes. The resting time was needed at least 90 minutes for adequate recovery.

2021-09-28 19:17:59
1 + 1 Wikipedia

1 0 0 0 細菌性赤痢ニ對スル「ウザラ」Uzaraノ效果ニ就テ

著者: 赤木金太郎
出版者: 岡山医学会
雑誌: 岡山醫學會雜誌 (ISSN:00301558)
巻号頁・発行日: vol.26, no.298, pp.678-682, 1914

2021-09-13 00:15:07
1 + 0 Twitter

1 0 0 0 IR ニガウリ抽出物の血糖降下作用に関する文献的考察

著者: 万倉三正野田泰子森昭胤
出版者: 岡山医学会
雑誌: 岡山医学会雑誌 (ISSN:00301558)
巻号頁・発行日: vol.124, no.1, pp.15-26, 2012-04

Diabetes mellitus (DM) represents a global health and economical problem. Many patients with DM in Asia, South America, India and East Africa have traditionally used the water extract of unripe fruits of Momordica charantia (bitter melon) as some form of complementary and alternative medicine. Studies of laboratory animals have shown the beneficial blood-glucose lowering and anti-diabetic effects of this remedy. Some oral components that bring lower blood glucose level have been isolated : charantin (sterol glycosides), charantin (polypeptide) and cucurbine-type triterpenes. Part of their actions are related to AMP-activated kinase and repression of the oxidative stress that is increased in DM. Most clinical reports are not fully convincing due to the lack of randomized control studies. The present article reviews the pharmacological and clinical effects of bitter melon with special emphasis on the anti-diabetic effects, and some effects that would require caution in the context of human trials.

2021-08-23 19:40:15
1 + 1 Wikipedia

https://ci.nii.ac.jp/naid/40019282371

1 0 0 0 肺、腹膜及腸殊ニ骨結核ニ於ケルローゼンバッハ氏「ツベルクリン」ノ治驗例

著者: 町田弘一
出版者: 岡山医学会
雑誌: 岡山醫學會雜誌 (ISSN:00301558)
巻号頁・発行日: vol.25, no.282, pp.492-502, 1913

2021-08-08 18:45:05
1 + 0 Twitter

1 0 0 0 IR 胃炎および胃潰瘍の組織化学的研究第1編水解酵素について

著者: 竹本茂
出版者: 岡山医学会
雑誌: 岡山医学会雑誌 (ISSN:00301558)
巻号頁・発行日: vol.78, no.7, pp.815-826, 1966-09-30

Using the human stomach tissues resected at the operation for gastric ulcer and gastritis, histochemical studies were carried on five kinds of hydrolysates such as AlP, AcP, beta-Est, AmP and beta-Gl and the following results were obtained.1. In gastritis the AlP activity in vascular endothelial cells has been observed even in those of the capillary blood vessels of the stomach mucosa.2. In the case of atrophic gastritis the activity of AcP, beta-Est and beta-Gl are somewhat decreased, while there can be seen no activity of AlP nor of AmP.3. In hypertrophic gastritis the activity of AcP, beta-Est and beta-Gl in the stomach mucosa is slightly elevated, but there can be observed no activity of AlP and AmP.4. While there can be observed a marked activity of AlP in the neoplasm at the fundus of gastric ulcer, the activity decreases as there occurs hyaline degeneration, and the regenerated blood capillary vessels in this regenerated area run perpendicularly to the ulcer base. In the stained specimens of these tissues from such a region there can be detected a slight activity of AcP and beta-Gl, but no activity of beta-Est, while that of AmP can be seen occasionally.5. In the regenerated mucosal gland ducts in the peripheral area of ulcer the activity of AcP, beta-Est and beta-Gl is found to have increased.6. In the case where the tissue has fallen into a degenerated necrotic state the activity of everyone of these hydrolysates is increased.7. In the area of intestinal metaplasia, all these enzymes show strong activity, resem-bling that in the villi of duodenum.8. In those smooth muscles adjacent to inflammatory region, the activity of beta-Est is specifically increased.9. The activity of AcP and beta-Gl of the epithelial cells in the area with marked cell infiltration is higher than in those epithelial cells located in other regions.

2021-07-26 03:45:06
1 + 0 Twitter

https://ci.nii.ac.jp/naid/120005815746

1 0 0 0 OA 大腸癌におけるKRAS, BRAF遺伝子突然変異とDNAメチル化

著者: 永坂岳司松原長秀笹本博美高畑隆臣竹田正範木村圭吾内田卓之石井龍宏長尾厚樹小南賢吉郎中川仁志神原健能登原憲司磯崎博司田中紀章
出版者: 岡山医学会
雑誌: 岡山医学会雑誌 (ISSN:00301558)
巻号頁・発行日: vol.117, no.2, pp.97-103, 2005-09-01 (Released:2011-06-03)
参考文献数: 27

2021-07-17 15:30:03
1 + 2 Twitter

1 0 0 0 OA 透析シャント心不全―非過大シャント心不全 “Non-High-Output Cardiac Failure”の病態―

著者: 鵜川豊世武
出版者: 岡山医学会
雑誌: 岡山医学会雑誌 (ISSN:00301558)
巻号頁・発行日: vol.127, no.3, pp.203-207, 2015-12-01 (Released:2016-01-04)
参考文献数: 25

Background: Hemodialysis-related heart failure has been considered to be associated with excessive blood flow through the arteriovenous (AV) shunt used for vascular access. However, some patients undergoing dialysis have heart failure in the absence of an increase in cardiac output (CO) related to shunt blood-flow loading because the loading cannot be compensated for by increasing CO. This condition may be challenging to manage ; thus, early diagnosis is important. Methods and Results: Twelve patients (mean age, 71 years ; 9 men) with end-stage renal disease, dialysis-related heart failure, a high brain natriuretic peptide (BNP) level, and a mean New York Heart Association (NYHA) class of II underwent AV shunt closure. Their cardiac index (CI), pre- and post-dialysis BNP levels, and several cardiac variables were assessed pre- and postoperatively. All patients achieved relief of heart failure symptoms and a reduction in NYHA class after AV closure, but six patients had a postoperative increase in CI (the “non-high-output” cardiac failure group), whereas the other six had a decrease in CI (the “high-output” cardiac failure group). The high-output patients had greater improvements in BNP levels and most cardiac variables compared to the non-high-output group ; therefore, the heart failure in the non-high-output patients was considered more serious than that in the high-output group. Conclusions: The selection of effective strategies for treating dialysis-related heart failure may depend partly on identifying which patients have non-high-output failure. Such identification requires serial measurements of BNP levels and evaluations of cardiac variables other than the ejection fraction.

2021-06-10 07:54:08
1 + 1 Twitter

1 0 0 0 IR 低用量経口避妊薬の使用に関するガイドライン

著者: 鎌田泰彦平松祐司
出版者: 岡山医学会
雑誌: 岡山醫學會雜誌 (ISSN:00301558)
巻号頁・発行日: vol.119, no.3, pp.315-317, 2008-01-01
参考文献数: 5

2021-05-31 05:58:33
1 + 1 Wikipedia

1 0 0 0 OA 極めて大量注射を行つた慢性覚醒剤中毒の一例に就いて

著者: 西紋孝
出版者: 岡山医学会
雑誌: 岡山医学会雑誌 (ISSN:00301558)
巻号頁・発行日: vol.68, no.5, pp.435-437, 1956-05-31 (Released:2009-03-30)
参考文献数: 1

2021-05-19 16:08:00
1 はてなブックマーク

1 0 0 0 IR 卵膜外リバノール液注入に依る姙娠中絶法

著者: 木田恵三花岡恒夫石田秀雅竹林康光
出版者: 岡山医学会
雑誌: 岡山医学会雑誌 (ISSN:00301558)
巻号頁・発行日: vol.66, no.3, pp.417-418, 1954

2020-11-26 21:02:32
1 + 0 Twitter

1 0 0 0 OA テロメラーゼ依存性腫瘍融解ウイルス療法の骨・軟部肉腫に対する前臨床的検討

著者: 佐々木剛田澤大長谷井嬢国定俊之吉田晶橋本悠里矢野修也吉田亮介宇野太香川俊輔森本裕樹浦田泰生藤原俊義尾﨑敏文
出版者: 岡山医学会
雑誌: 岡山医学会雑誌 (ISSN:00301558)
巻号頁・発行日: vol.124, no.2, pp.105-110, 2012-08-01 (Released:2012-09-03)
参考文献数: 15

骨・軟部肉腫は, 一部に治療抵抗性で予後の悪い症例が存在するため, 新たな治療法の確立が重要な課題である. 我々は, 5型アデノウイルスを基本骨格として, テロメラーゼ活性に依存して増殖する腫瘍融解ウイルス(OBP-301)や, coxsackie and adenovirus receptor(CAR)陰性の腫瘍細胞に感染するファイバー改変型ウイルス(OBP-405)を用い, 骨・軟部肉腫細胞に対する抗腫瘍効果を検討した. 14種類の骨・軟部肉腫細胞株に対してOBP-301の細胞障害活性を検討し, 12種類の細胞株でOBP-301に感受性を認めた. また, OBP-301の細胞障害活性はCARの発現と相関していた. さらに, テロメラーゼ活性の低い細胞に対しても, 5型アデノウイルスの複製に必須のE1Aによりテロメラーゼ活性の増強効果がおこり, 強い抗腫瘍活性を示すことを明らかにした. 次に, 骨肉腫脛骨同所性移植動物モデルを作成しOBP-301を投与したところ, OBP-301投与群では対象群と比べて有意に腫瘍増殖を抑制した. 最後に, OBP-301に感受性を認めなかったCAR陰性細胞株に対してOBP-405を用いて検討し, OBP-405が有効に作用することを確認した. OBP-301やOBP-405を用いたウイルス療法は, 骨・軟部肉腫に対する新たな治療法となる可能性がある.