著者

Takayuki MINESHIGE Junichi KAMIIE Go SUGAHARA Kinji SHIROTA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.80, no.1, pp.103-111, 2018 (Released:2018-01-27)

参考文献数

30

被引用文献数

11

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Atopic dermatitis (AD) is a chronic, pruritic, and allergic skin disease in humans and animals, particularly dogs. Canine AD (cAD) has received attention as a spontaneous atopic animal model because domesticated dogs inhabit a human environment, and cAD shares several clinicopathological features with human AD (hAD). In hAD, periostin (PO) is suggested to play a critical role in the enhancement and chronicity of allergic skin inflammation; however, PO involvement in the pathogenesis of cAD is unknown. Here we aimed to clarify PO involvement in the pathophysiology of cAD and focused on the inducing factor and function of PO in canine atopic skin. Using double-labeled in situ hybridization (ISH), interleukin (IL)-13 mRNA-positive cells were detected near the keratinocytes and dermal fibroblasts expressing PO mRNA in atopic skin. Using an in vitro assay, IL-13 induced PO gene expression in both canine dermal fibroblasts and keratinocytes. PO enhanced in vitro growth of canine keratinocytes. Moreover, among PO-induced genes in cultured canine keratinocytes detected using a microarray, we identified IL-25 as a possible mediator in canine atopic skin. In addition, real time polymerase chain reaction (PCR) analysis revealed upregulation of IL-25 gene expression in PO-stimulated keratinocytes. These data suggest that IL-13 possibly derived from T helper 2 (Th2) cells stimulates PO production in both keratinocytes and fibroblasts, and then PO may play a critical role in the pathophysiology of cAD, particularly in the enhancement and chronicity of skin lesions via IL-25.

著者

Sam Thi NGUYEN Yasuhiro FUKUDA Duc Tan NGUYEN Ha Thanh DAO Duc Quyet LE Khanh Linh BUI Chika TADA Yutaka NAKAI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.80, no.1, pp.92-97, 2018 (Released:2018-01-27)

参考文献数

26

被引用文献数

10

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This study was carried out to determine the prevalence, genotypes/assemblages and possible risk factors associated with Giardia duodenalis infection in dogs in central Vietnam. A total of 209 dog fecal samples, randomly collected from private owned dogs (n=105) and dogs from stores (n=104), were examined for Giardia cysts by microscopy. Positive samples were genotyped by PCR-sequence analysis of β-giardin and triosephosphate isomerase genes markers. Risk factors were studied using a structured questionnaire and collected data were analyzed by univariate and multivariate logistic regression analyses. Results indicated that the overall infection rate was 8.6% (18/209) with the detected parasites were belonging to the non-zoonotic assemblages C and D. Age, gender and origin of animals were the main risk factors associated with G. duodenalis infection in dogs under study. Occurrence of infection was more likely in young animals compared to old ones and in females compared to males. Dogs originated from stores were more prone to Giardia infection compared to private owned counterparts.

著者

Dafei LIU Fei LIU Dongchun GUO Xiaoliang HU Zhijie LI Zhigang LI Jianzhang MA Chunguo LIU

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.17-0442, (Released:2018-01-23)

被引用文献数

6

---

To rapidly distinguish Canine distemper virus (CDV), canine parvovirus (CPV), and canine kobuvirus (CaKoV) in practice, a one–step multiplex PCR/RT–PCR assay was developed, with detection limits of 102.1 TCID50 for CDV, 101.9 TCID50 for CPV and 103 copies for CaKoV. This method did not amplify nonspecific DNA or RNA from other canine viruses. Therefore, the assay provides a sensitive tool for the rapid clinical detection and epidemiological surveillance of CDV, CPV and CaKoV in dogs.

著者

Thillaiampalam SIVAKUMAR Dinh Thi Bich LAN Phung Thang LONG Le Quoc VIET Gayani WEERASOORIYA Aiko KUME Keisuke SUGANUMA Ikuo IGARASHI Naoaki YOKOYAMA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.17-0549, (Released:2017-12-15)

被引用文献数

5

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Serum and DNA from blood samples collected from Vietnamese yellow cattle (n=101) and cattle imported from Thailand (n=54) at a Vietnamese slaughter house were screened for Babesiabovis and Babesiabigemina infections by enzyme-linked immunosorbent assay (ELISA) and PCR. The positive rates determined by ELISA (B. bovis and B. bigemina) or PCR (B. bigemina) in the Vietnamese cattle were significantly higher than those found in Thai cattle. Some PCR-positive Vietnamese animals were ELISA-negative, whereas all PCR-positive Thai cattle were ELISA-positive, suggesting that the animals were infected in Thailand. Importing Babesia-infected cattle may lead to the introduction of new parasite strains, possibly compromising the development of anti-Babesia immune control strategies in Vietnam.

著者

Masashi KAWASHIMA Risa SEGAWA Toshinori YOSHIDA Hirotada MURAYAMA Rei NAGAHARA Masayuki KIMURA Natsumi ENDO Tomomi TANAKA Makoto SHIBUTANI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.79, no.6, pp.1091-1095, 2017 (Released:2017-06-29)

参考文献数

13

被引用文献数

4

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An 11-year-old female goat had invasive and metastatic endometrial adenocarcinoma in the uterus. There was a notable proliferation of endometrial epithelial cells in a tubular growth pattern, with a desmoplastic response. The endometrial epithelial tumor cells metastasized to the kidney, liver and lung. In contrast to the primary and metastatic tumor cells, pleomorphic tumor cells with a choriocarcinoma-like growth pattern infiltrated the mesometrium. Cell proliferation activity was high in both types of tumor cells. Both types of tumor cells expressed cytokeratins AE1/AE3, 7 and CAM5.2; choriocarcinomatous cells also had positive immunoreactions to human chorionic gonadotropin, human placental alkaline phosphatase and α-inhibin. The present case was diagnosed as endometrial adenocarcinoma with choriocarcinomatous differentiation.

著者

Takanori SHIGA Seiichi OKUNO Kazuyuki UCHIDA James K. CHAMBERS Hiroyuki NAKAYAMA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.17-0459, (Released:2018-01-02)

---

An 8-year-old male Japanese Shiba exhibited muscle wasting and a stiff gait. A low-amplitude myotonic discharge was recorded by needle electromyography (EMG). A histopathological examination on a tru-cut biopsy sample from the muscle revealed myofiber size variations. Internal nuclei and cytoplasmic vacuoles were observed in many fibers. A type 1 fiber predominance and many hybrid type fibers were observed immunohistochemically. On the basis of these EMG and histopathological findings, myotonic dystrophy (DM) was suspected as tentative diagnosis. The cytoplasm around the vacuoles was immunopositive for cytochrome c, tom 20, and SOD-1, suggesting that these vacuoles might occur within mitochondria. Collectively, these results indicate that a mitochondrial abnormality partly play the role on the pathogenesis of present case.

著者

Reiichiro SATO Ken ONDA Masaru MURAKAMI Daiya ITO Hiroo MADARAME

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.79, no.7, pp.1151-1154, 2017 (Released:2017-07-07)

参考文献数

23

被引用文献数

3

---

A Holstein calf was born with a large protruding right eye and a central corneal opacity. Enucleation was the first choice of treatment. The calf had a good prognosis and was raised for milking purposes. Macroscopically, the enucleated eye was characterized by the protruded cornea, adherence of the iris to the central posterior cornea and aphakia. Microscopically, central corneal thickening and a defect in the endothelium and Descemet’s membrane were observed. These data suggest that this represents a case of unilateral anterior segment dysgenesis consistent with congenital corneal staphyloma with Peters’ anomaly and aphakia. Neither a mutation of the WFDC1 gene in multiple ocular defects nor any other identifiable cause for ocular anomalies was detected.

著者

Mizuki KURAMOCHI Takeshi IZAWA Shin NISHIMURA Terumasa SHIMADA Mitsuru KUWAMURA Jyoji YAMATE

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.79, no.7, pp.1163-1166, 2017 (Released:2017-07-07)

参考文献数

14

被引用文献数

1

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An 11-year-old female golden retriever dog had a mass at the right corner of the upper lip, which gradually increased in size and protruded into the oral cavity. The mass was removed surgically. The cut surface of the mass was smooth, whitish and solid, and covered by the oral mucosal membrane. Histopathologically, the mass consisted mainly of reticular pattern of short spindle cells that stained positively for cytokeratin AE1/AE3, α-smooth muscle actin and p63, suggestive of a myoepithelial cell phenotype. Between the neoplastic cords, there was myxoid or edematous connective tissue. Additionally, neoplastic cells with luminal epithelial and basal cell phenotypes were arranged in ducts and small islands, respectively. Based on the diverse histological and immunohistochemical features, the tumor was diagnosed as pleomorphic adenoma of the labial gland. To our knowledge, the reticular proliferation pattern of myoepithelial cells has not been described in salivary gland tumors of domestic animals.

著者

Sam Thi NGUYEN Yasuhiro FUKUDA Duc Tan NGUYEN Ha Thanh DAO Duc Quyet LE Khanh Linh BUI Chika TADA Yutaka NAKAI

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.17-0498, (Released:2017-11-29)

被引用文献数

10

---

This study was carried out to determine the prevalence, genotypes/assemblages and possible risk factors associated with Giardia duodenalis infection in dogs in central Vietnam. A total of 209 dog fecal samples, randomly collected from private owned dogs (n=105) and dogs from stores (n=104), were examined for Giardia cysts by microscopy. Positive samples were genotyped by PCR-sequence analysis of β-giardin and triosephosphate isomerase genes markers. Risk factors were studied using a structured questionnaire and collected data were analyzed by univariate and multivariate logistic regression analyses. Results indicated that the overall infection rate was 8.6% (18/209) with the detected parasites were belonging to the non-zoonotic assemblages C and D. Age, gender and origin of animals were the main risk factors associated with G. duodenalis infection in dogs under study. Occurrence of infection was more likely in young animals compared to old ones and in females compared to males. Dogs originated from stores were more prone to Giardia infection compared to private owned counterparts.

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:13477439)

巻号頁・発行日

pp.17-0453, (Released:2017-11-27)

被引用文献数

11

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of The Japanese Society of Veterinary Science (ISSN:18839193)

巻号頁・発行日

vol.17, no.3, pp.208-209,en33, 1938 (Released:2009-02-24)

被引用文献数

1

著者

Zarkasie Kamaluddin 沢田 拓士 吉田 孝冶 高橋 勇 高橋 敏雄

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.58, no.1, pp.87-90, 1996

被引用文献数

6

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血清型2型の豚丹毒菌5株の液体培地における増殖性, 全培養菌液で調製した不活化ワクチンのマウスにおける免疫原性, 菌体表層蛋白のSDS-PAGEプロファイル, およびそのイムノブロット像を比較したところ, 多摩-96株は安定した増殖性を示し, 免疫原性が最も高かった. 菌体表層蛋白のSDS-PAGE像とイムノブロット像は供試株間でほぼ類似し, 66-64kDa蛋白が主要共通抗原として認められた.

著者

Isao MATSUMOTO James Kenn CHAMBERS Yasutsugu MIWA Hiroyuki NAKAYAMA Kazuyuki UCHIDA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.79, no.6, pp.979-983, 2017 (Released:2017-06-10)

参考文献数

10

被引用文献数

4

---

Anaplastic large T-cell lymphoma (ALTCL) is rarely reported in domestic animals. Accordingly, the histopathological and immunohistochemical characteristics of ALTCL have not been well established in prairie dogs. The present report documents three cases in which prairie dogs were diagnosed with ALTCL arising in the subcutaneous tissue, oral mucosa or the mesenteric lymph nodes. Of the three cases, one was available for necropsy and the others were biopsy cases. Microscopically, moderate to large, pleomorphic neoplastic lymphocytes with ovoid to polygonal, bizarre-shaped nuclei, abundant cytoplasm and eosinophilic granules were seen in all cases. Immunohistochemical staining revealed membranous or cytoplasmic CD3 expression of the neoplastic lymphocytes. The neoplastic cells often had granzyme B-positive cytoplasmic granules. One of the prairie dogs with nodal ALTCL suffered systemic dissemination of the tumor and died suddenly. In the two biopsy cases, one animal died on the day of the biopsy examination and the other died six weeks after chemotherapy. ALTCL in prairie dogs displays a cytotoxic T cell phenotype and presumably carries a poor prognosis regardless of the anatomical type.

著者

Josué DÍAZ-DELGADO Roy POOL Sharman HOPPES Argine CEREZO Óscar QUESADA-CANALES George STOICA

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.79, no.5, pp.889-895, 2017 (Released:2017-05-18)

参考文献数

49

被引用文献数

14

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This report describes the clinical, macroscopic, histopathological and immunohistochemical features of a spontaneous multicentric extraskeletal sarcoma in an adult male African hedgehog (Atelerix albiventris). It also provides a succinct up-to-date review on neoplasia in this species. On autopsy examination, main gross findings included a moderately demarcated cranial mass and a multilobulated, caudal intra-abdominal mass. The cranial mass had perforated the underlying temporal and occipital bones and had extended into the cranial vault and was compressing the surface of the cerebellum and cerebrum. Histologic, histochemical and immunohistochemical analyses supported a diagnosis of multicentric poorly differentiated spindle cell sarcoma with fibrosarcomatous, storiform and myxoid foci. The high incidence of neoplasia and cross similarities renders the African hedgehog a suitable species for comparative pathology studies.

著者

Yoshinori TAKAMI Namie YASUDA Yumi UNE

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.79, no.1, pp.171-174, 2017 (Released:2017-01-20)

参考文献数

27

被引用文献数

1 6

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A penile tumor (4 × 2.5 × 1 cm) was surgically removed from an African pygmy hedgehog (Atelerix albiventris) aged 3 years and 5 months. The tumor was continuous with the dorsal fascia of the penile head. Histopathologically, tumor cells were pleomorphic (oval-, short spindle- and star-shaped cells) with low cell density. Abundant edematous stroma was weakly positive for Alcian blue staining and positive for colloidal iron reaction. Tumor cells displayed no cellular atypia or karyokinesis. Tumor cell cytoplasm was positive for vimentin antibody, while cytoplasm and nuclei were positive for S-100 protein antibody. Tumor cell ultrastructure matched that of fibroblasts, and the rough endoplasmic reticulum was enlarged. The tumor was diagnosed as myxoma. This represents the first report of myxoma in a hedgehog.

著者

農商務省畜産局

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

中央獸醫會雑誌 (ISSN:18839096)

巻号頁・発行日

vol.37, no.6, pp.530-541, 1924

著者

AOKI Takuma SUNAHARA Hiroshi SUGIMOTO Keisuke ITO Tetsuro KANAI Eiichi NEO Sakurako FUJII Yoko WAKAO Yoshito

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.77, no.9, pp.1187-1190, 2015

被引用文献数

2

---

Dynamic left ventricular outflow tract obstruction (DLVOTO) is a common condition in cats and humans. In this case report, a dog is described with DLVOTO secondary to severe intra-abdominal hemorrhage caused by a hemangiosarcoma. The dog was a 9-year-old, 35.7-kg, spayed female German Shepard dog that presented with a history of tachypnea and collapse. A Levine II/VI systolic murmur was present at the heart base. Abdominal ultrasonography revealed a splenic mass and a large amount of ascites. Echocardiography showed a reduced left ventricular diameter and an increased aortic velocity caused by systolic anterior motion (SAM) of the mitral valve apparatus. The heart murmur and the SAM were resolved after treatment including a splenectomy and a blood transfusion.

著者

村上 昇 高橋 清久 黒田 治門 江藤 禎一

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

日本獸醫學雜誌(The Japanese Journal of Veterinary Science) (ISSN:00215295)

巻号頁・発行日

vol.48, no.1, pp.29-34, 1986

被引用文献数

1

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偽妊娠ラットにおいて, 制限給餌のプロラクチンサージおよびコルチコステロンリズムに及ぼす効果を検討した。成熟雌ラットを, 14L:10D (グループ1: 5時点灯19時消灯, グループ2: 19時点灯7時消灯)の条件下で飼育し, それぞれのグループに自由給餌群と, 毎日9-11時のみ2時間の制限給餌群を設け, 23日後の発情前期に子宮頸部刺激で偽妊娠を誘起した。自由給餌群では, ノクターナルサージおよびダイアーナルサージは, グループ1ではそれぞれ3時および18時に, グループ2では15時および6時に認められ, プロラクチンサージがそれぞれの光条件に同調していることがわかった。一方, 制限給餌群では, 両グループともにノクターナルサージは影響を受けなかったが, ダイアーナルサージは消失した。血中コルチコステロンリズムは両グループともに, 制限給餌直前にピークを示した。以上の結果から, 偽妊娠ラットのプロラクチンサージでノクターナルサージとダイアーナルサージの成立には別の機構が存在する可能性が示唆された。

著者

須藤 義衛門

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

中央獸醫會雑誌 (ISSN:18839096)

巻号頁・発行日

vol.13, no.4, pp.1-5, 1900

著者

高瀬 公三 馬場 守ジルベルト 西 理佳子 藤川 英雄 山田 進二

出版者

JAPANESE SOCIETY OF VETERINARY SCIENCE

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

vol.57, no.2, pp.327-330, 1995

被引用文献数

1

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発育鶏卵漿尿膜(CAM)及び鶏腎培養細胞(CK)由来の鶏アデノウイルス(FAV)寒天ゲル内沈降(AGP)抗原の反応性を実験感染鶏血清及び野外鶏血清を用いて比較し, 次の成績を得た. 実験感染鶏血清の両由来抗原による陽性率はFAVの株(血清型)の違いによって異なり, ヘテロ抗原での陽性率はホモ抗原でのそれに比べて低く, またヘテロ抗原での抗体価もホモ抗原の抗体価に比べて低い傾向を示した. さらに, CAM由来抗原を用いた方がCK由来抗原の場合よりも高い陽性率, 又は高い抗体価の得られる場合が多かった. CAM由来抗原を用いて野外鶏血清を検査したところ, 用いる抗原(血清型)によって抗体陽性率は異なったが, 複数の抗原を混合することにより, 陽性率は高まった. このことから, FAVの血清疫学調査にはCAM由来の複数の血清型のAGP抗原を用いて行うことが望ましいと考えられた.