281 0 0 0 OA 生薬粉末製剤の流動特性評価ならびに薬匙設計のための評価法―鎮咳去痰薬生薬製剤における取り組み―
- 著者
- 竹内 淑子 中坪 拓也 福居 篤子 藤井 隆太 田原 耕平 竹内 洋文
- 出版者
- 公益社団法人 日本薬剤学会
- 雑誌
- 薬剤学 (ISSN:03727629)
- 巻号頁・発行日
- vol.77, no.3, pp.164-176, 2017-04-01 (Released:2017-05-01)
- 参考文献数
- 19
Flowability is one of the most important parameters of pharmaceutical powders during the handling and preparation of solid dosage forms. It is especially important to characterize the very poor flowability that some herbal powders show. In this study, the flowability of a traditional herbal powder formulated as an antitussive and expectorant was examined. This formulated herbal powder and two excipient powders, precipitated calcium carbonate and anhydrous dibasic calcium phosphate, were evaluated using two instruments. A shearing test, a wall friction test and a dynamic flowability test were performed with Powder Rheometer FT4 (Freeman Technology, Tewkesbury, UK). Internal friction and wall friction were measured. BFE (basic flow energy), SI (stability index) and FRI (flow rate index) were also measured. Angle of repose, bulk density, tapped density, angle of spatula and cohesiveness were measured with a Powder Tester (Hosokawa Micron, Osaka, Japan). The results were used to calculate Carr's Index values and compressibility, which in turn revealed that this herbal powder had poor flowability.The other aim of this study was to develop a new method of evaluating the flowability of powder through a medicine spoon. Two evaluation methods, the spoon-tap test and the consecutive medicine spoon test, were developed to design a new medicine spoon for the herbal powder. The results of these tests indicated that a polyethylene medicine spoon with holes at the bottom could reduce the adhesiveness to a medicine spoon of the formulated herbal powder.
言及状況
外部データベース (DOI)
Twitter (281 users, 291 posts, 35 favorites)
@GSR250w 開発経緯と理論についてはこちらに（ぜんぜんわからん）
https://t.co/wwMs8rKpLs
そして薬剤学の論文を見るとガチで流体力学使っていて，岐阜薬科大学製剤
学研究室の研究だったり．微分積分だけでなく物理も勉強しないといけない．
https://t.co/xZWQNERmmH
@mhl_bluewind とりあえず、該当論文を読んで下さいな…
https://t.co/EFulraHmul
科学クラスタが興味を示しているので、該当論文をリンクしとく。
主に粉（龍角散）の分析を密にやって、その流動性を確認、後は薬匙の材質や匙底部に設けた開孔部の付着抑制の効果を分析した模様です<(｀･ω･´) https://t.co/EFulraHmul
@TBDD_yahoo とりあえず、該当論文はコレよ(・∀・)っ https://t.co/EFulraHmul
これが龍角散の3つ穴が開いている匙の粉体力学の論文か！
生薬粉末製剤の流動特性評価ならびに薬匙設計のための評価法
―鎮咳去痰薬生薬製剤における取り組み―
https://t.co/lO5edNlRxo
ドヤ顔でこの論文上げてるけど（https://t.co/FLYNv6YheE）薬さじの設計に関しては試行錯誤しかしてないんだよなあ。論文読めてなさそう？粉体の性状の理論的理解から設計の絞り込みや実験結果の整理は出来て，抜けがないこ… https://t.co/3omNCGV721
ほらよ(´・ω・｀)っ https://t.co/EFulraHmul https://t.co/yQMns9Qr1X
ほう．粉体力学を応用したさじとな．
https://t.co/gakxP5mgze
https://t.co/BaZHWiF4te