著者

竹内 淑子 中坪 拓也 福居 篤子 藤井 隆太 田原 耕平 竹内 洋文

出版者

公益社団法人 日本薬剤学会

雑誌

薬剤学 (ISSN:03727629)

巻号頁・発行日

vol.77, no.3, pp.164-176, 2017-04-01 (Released:2017-05-01)

参考文献数

19

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Flowability is one of the most important parameters of pharmaceutical powders during the handling and preparation of solid dosage forms. It is especially important to characterize the very poor flowability that some herbal powders show. In this study, the flowability of a traditional herbal powder formulated as an antitussive and expectorant was examined. This formulated herbal powder and two excipient powders, precipitated calcium carbonate and anhydrous dibasic calcium phosphate, were evaluated using two instruments. A shearing test, a wall friction test and a dynamic flowability test were performed with Powder Rheometer FT4 (Freeman Technology, Tewkesbury, UK). Internal friction and wall friction were measured. BFE (basic flow energy), SI (stability index) and FRI (flow rate index) were also measured. Angle of repose, bulk density, tapped density, angle of spatula and cohesiveness were measured with a Powder Tester (Hosokawa Micron, Osaka, Japan). The results were used to calculate Carr's Index values and compressibility, which in turn revealed that this herbal powder had poor flowability.The other aim of this study was to develop a new method of evaluating the flowability of powder through a medicine spoon. Two evaluation methods, the spoon-tap test and the consecutive medicine spoon test, were developed to design a new medicine spoon for the herbal powder. The results of these tests indicated that a polyethylene medicine spoon with holes at the bottom could reduce the adhesiveness to a medicine spoon of the formulated herbal powder.

著者

藤井 隆太 高木 綾一 山口 剛司 高崎 恭輔 大工谷 新一 鈴木 俊明

出版者

関西理学療法学会

雑誌

関西理学療法 (ISSN:13469606)

巻号頁・発行日

vol.8, pp.85-94, 2008 (Released:2009-01-15)

参考文献数

13

被引用文献数

2

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The purpose of this study was to investigate the effect of differences of the foot center of pressure in standing on postural control of stand-to sit movement. It was thought that the reverse reaction phenomenon of standing posture in normal subjects at the fist of the sitting movement start by reduction of the muscle activity of the lumbar back muscles. Stable stand-to-sit movement was able to be performed when COP was located forward. From this, the position of foot COP in standing before stand-to-sit movement influences the difficulty of adjustment of COP and COG. Therefore, we suggest that in order to improve stand-to-sit movement, it is important to evaluate foot COP in the standing posture and muscle activity of the lumbar back muscles.

著者

藤井 隆太朗 向井 克容 細野 昇 坂浦 博伸 石井 崇大 岩崎 幹季 菅本 一臣 吉川 秀樹

出版者

医学書院

雑誌

臨床整形外科 (ISSN:05570433)

巻号頁・発行日

vol.40, no.7, pp.763-769, 2005-07-01

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In vivoでの3次元腰椎回旋運動解析は,従来の方法では高精度な解析は困難であった.今回,われわれは3D-MR画像を用いた新しい非侵襲的3次元動態解析システムを使って,体幹回旋時の腰椎3次元運動を解析したので報告する.各椎間の平均回旋角度は片側1°~2°であった.腰椎の回旋運動はL1/2~L4/5において回旋と反対方向の側屈,T12/L1とL5/S1において回旋と同方向の側屈を伴っていた.また腰椎の回旋はL1/2~L5/S1で前屈を伴い,T12/L1で後屈を伴った.われわれの解析結果はin vivoでの2方向X線撮影を用いたPearcyらの報告と同じ傾向であったが,in vitroでの新鮮屍体を用いたPanjabiらは下位腰椎(L4/5,L5/S1)では回旋と同側方向への側屈を伴ったとしており,L4/5においてPanjabiらの結果とは異なっていた.

著者

福居 篤子 藤井 隆太 砂田 久一

雑誌

薬剤学 = Journal of Pharmaceutical Science and Technology, Japan (ISSN:03727629)

巻号頁・発行日

vol.60, no.1, pp.62-70, 2000-03-20

参考文献数

19

被引用文献数

8