著者

黒崎 理絵 堀川 淳子 江嵜 高史 朝枝 哲也 池田 正之 乾 修然

出版者

公益社団法人日本産業衛生学会

雑誌

産業衛生学雑誌 (ISSN:13410725)

巻号頁・発行日

vol.40, 1998-03-20

著者

高橋 伯夫 松沢 誠 池垣 岩夫 西村 眞人 増井 一郎 山田 親久 乾 修然 吉村 学

出版者

社団法人 日本腎臓学会

雑誌

日本腎臓学会誌 (ISSN:03852385)

巻号頁・発行日

vol.32, no.1, pp.53-64, 1990 (Released:2011-07-04)

参考文献数

30

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We assessed the role of circulating digitalislike substance (s) on the blood pressure regulation in patients with essential hypertension, cardiac diseases, diabetes mellites and renal diseases by measuring digoxin-like immunoreactivity (DLI). Plasma DLI concentrations tended to correlate with blood pressure in all patient groups. Plasma DLI correlated to plasma aldosterone concentration in patients with essential hypertension, which suggested close interrelationship between DLI and electrolytes metabolism with adrenal steroids. Serum immunoreactive insulin (IRI) levels significantly correlated with blood pressure. Because plasma DLI levels correlated with serum IRI, increased levels of insulin could have induced sodium retention leading to increased DLI levels. Digitalislike substance, but not insulin, would have directly increased blood pressure in patients with abnormal glucose tolerance. Plasma DLI levels significantly correlated with the severity of renal insufficiency in patients with renal diseases. Plasma DLI highly correlated with amounts of plasma pro-teins, particularly with albumin, which would be due to the binding of DLI with albumin in plasma. Because the level of non-binding DLI is extremely low when assayed with a digoxin-radioimmunoassay, it was impossible to assess the level of a free-form of DLI, i.e., active DLI. That could be a reason why the correlation between the DLI and the other parameters was not highly significant. Collectively, these findings suggest that the DLI is one of the major determinants of blood pressure rises, regardless of any cause.

著者

佐野 晴洋 山下 節義 川西 正祐 井口 弘 吉永 侃夫 小城 勝相 塚本 幾代 藤田 博美 岡本 浩子 加藤 伸勝 宮本 宣博 浮田 義一郎 山根 秀夫 森 律 池田 栄三 乾 修然 藤岡 惇 阿部 醇吉

出版者

日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.37, no.2, pp.566-579, 1982-06-30 (Released:2009-02-17)

参考文献数

32

被引用文献数

1 3

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An epidemiological survey and clinical investigations were carried out on 162 retired workers from manganese mines and ore grinders, who were the residents of the Tamba district of Kyoto Prefecture. Most of the workers had been employed in small industrial factories with less than five employees under very poor working conditions. Fifty-five percent of them had worked in the mines and factories for longer than 11 years. Forty-six percent had been retired for 11-20 years, whereas 27% for longer than 21 years. A group of 124 people living in the same region but who had not been exposed to manganese served as the control group.The incidence of subjective symptoms associated with chronic manganese poisoning such as emotional instability, psychomotor irritability and neurologic abnormalities was apparently high in the experimental group and it increased with the period of exposure to manganese dust. Twenty-eight percent of the workers reported the subjective symptoms while they were employed, but 45% of them reported as late as six years after they retired.Of the retired workers, five (3.1%) had parkinsonism, three (1.9%) showed symptoms of hemiparkinsonism, and fifteen (9.3%) showed neurological symptoms including maskedlike, gait unbalance, slurred speech and imparied fine movements. Forty-five percent of these patients recognized these abnormalities for more than five years after they had left the contaminated workings. It is noteworthy that 39% of the retired workers were diagnosed as having pneumoconiosis.Some of the problems encountered in diagnosing manganese poisoning after exposure has been terminated is also discussed here.