著者

池田 裕子 岡本 真理子 山本 健 今村 武浩 山近 重生 斎藤 一郎 中川 洋一

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.33, no.1, pp.10-17, 2014-04-01 (Released:2014-09-05)

参考文献数

26

被引用文献数

4

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Purpose: The purpose of this study was to investigate sleep quality and its related factors in dry-mouth patients. Subjects and Methods: A cross-sectional study was conducted in 362 patients who visited the Dry Mouth Clinic at Tsurumi University Dental Hospital with the complaint of oral dryness. Sleep quality was assessed using the Japanese version of the Pittsburgh Sleep Quality Index (PSQI-J), and factors associated with the PSQI-J global score were analyzed by multiple regression. The dependent variable was the PSQI-J global score, while age, gender, resting saliva flow rate (RSFR), stimulated saliva flow rate (SSFR), VAS score of nocturnal dry mouth sensation, the presence or absence of snoring, grinding, clenching, and mouth breathing, and anxiety and depression score in the Hospital Anxiety Depression Scale (HADS) were used as the independent variables. Results: The mean PSQI-J global score was 7.9±3.9, and 232/362 (64.1%) cases were considered to be poor sleepers who showed a score of less than 5.5. The multiple regression analysis showed that anxiety (standardizing coefficient 0.330) and depression score (0.151) in HADS, nocturnal dry-mouth sensation (0.165), and age (0.209) were significantly associated with the PSQI-J global score. Conclusion: Anxiety, depression, and sleep-related xerostomia were found to be factors closely associated with the risk of disturbance of good sleep quality.

著者

山本 健 山近 重生 今村 武浩 木森 久人 塩原 康弘 千代 情路 森戸 光彦 山口 健一 長島 弘征 山田 浩之 斎藤 一郎 中川 洋一

出版者

一般社団法人 日本老年歯科医学会

雑誌

老年歯科医学 (ISSN:09143866)

巻号頁・発行日

vol.22, no.2, pp.106-112, 2007-09-30 (Released:2011-02-25)

参考文献数

23

被引用文献数

16

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ドライマウスにおける加齢の関与を検討するため, 2002年11月から2007年4月までに鶴見大学歯学部附属病院ドライマウス専門外来を受診した2, 269名を対象に, 1.性別と年齢, 2.主訴・受診の動機, 3.全身疾患, 4.常用薬剤, 5.唾液分泌量, 6.ドライマウスの原因の集計を行い, 次のような結果を得た。1) 受診者の男女比は17: 83であり, 男女とも50歳代から受診者数が増加し, 女性では60歳代, 男性では70歳代の受診が最も多かった。2) 65歳未満と比較し, 高齢者では男性の受診率が増加しており, 高齢者での性差の縮小がみられた。3) 口腔乾燥感を主訴とする受診者は44.1%であり, 口腔粘膜の疼痛 (28.7%), 唾液や口腔内の粘稠感 (8.3%), 違和感・異物感 (7.1%), 味覚異常 (3.1%), 口臭 (1.9%) の順に多かった。4) 全身疾患は, 高血圧が30.7%に認められ, 次に脳血管障害を含む精神・神経系疾患 (25.4%) が多かった。5) 非シェーグレン症候群性ドライマウスは92.5%にみられた。6) シェーグレン症候群は, 全調査対象の7.0%であり, そのうち65歳以上の高齢者が53.5%を占めていた。以上のような結果から, ドライマウスの成立機序には加齢に伴う複合的な要因の関与が示唆された。

著者

鴨井 美帆 今村 武浩 山本 健 岡本 真理子 高橋 実里 園田 華子 西岡 千賀子 門松 伸一 山近 重生 斎藤 一郎 中川 洋一

出版者

日本歯科薬物療法学会

雑誌

歯科薬物療法 (ISSN:02881012)

巻号頁・発行日

vol.30, no.3, pp.85-91, 2011-12-01 (Released:2012-02-07)

参考文献数

18

被引用文献数

1

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Purpose: The purpose of this study was to investigate the effects of sulpiride, an antidepressant, on xerostomia.Method: Fifty-five patients who visited the Dry Mouth Clinic, Tsurumi Dental Hospital with subjective oral dryness were enrolled in this study. The cause of the xerostomia in the patients was unknown. The patients did not meet Sjögren's syndrome criteria, and their condition was not congruent with xerostomia caused by radiation therapy to the head and neck, HIV infection, chronic graft-vs-host disease, or diabetes mellitus. The patients were divided into two groups: the dry group, with the chief complaint of dry mouth, and the pain group, with the chief complaint of pain. The patients received oral administration of sulpiride, and the clinical efficacy was evaluated by doctors' subjective judgment and by visual analogue scale (VAS).Results: Sulpiride was effective in both groups, but the response rate was higher in the pain group than in the dry group according to the doctors' subjective judgment. In the evaluation by VAS, improvements were not obtained in other items such as thirstiness and dysgeusia, although a significant decrease of VAS value was found in "dry mouth" in the dry group. In contrast, in the pain group, significant improvements were found in all items as well as pain.Conclusions: The results suggested that the dry and pain groups possessed completely different pathophysiologies. The results also suggested that subjective dry mouth may be a partial symptom of burning mouth syndrome (BMS), and that depression was one of the causative factors of xerostomia.