著者
八十島 誠 山下 尚之 中田 典秀 小森 行也 鈴木 穣 田中 宏明
出版者
公益社団法人 日本水環境学会
雑誌
水環境学会誌 (ISSN:09168958)
巻号頁・発行日
vol.27, no.11, pp.707-714, 2004-11-10 (Released:2008-01-22)
参考文献数
45
被引用文献数
4 3

In recent years, antibiotics resident in sewage and in the water environment have become an emerging public concern in many developed countries. However, limited knowledge is available on the occurrence of antibiotics in sewage and discharge from wastewater treatment plants (WWTPs) in Japan. Moreover, little is known on the significance of their occurrence in the water environment from the viewpoints of biological adverse effects. The objectives of this research were, therefore, to determine the occurrence of selected antibiotics, namely levofloxacin (LVFX) and clarithromycin (CAM). That are commonly used in Japan, in discharge from WWTPs and then to evaluate their possible effects on algal growth. Therefore, we developed a novel analysis method for LVFX and CAM in wastewater by LC/MS/MS whose detection limits and recovery ratios are 2-3ng·l-1 and 53-87%, respectively. We also conducted algal growth inhibition tests using Pseudokirchneriella subcapitata, and results showed that the EC50s of LVFX and CAM are 1200μg·l-1 and 11μg·l-1, LOECs are 630μg·l-1 and 6.3μg·l-1, and NOECs are 310μg·l-1 and 3.1μg·l-1, respectively, LVFX and CAM concentrations in secondary effluent of five WWTPs that use the activated sludge process ranged from 152-323ng·l-1 and 303-567ng·l-1, respectively, which indicates that the PEC/PNEC ratio of LVFX is less than one but that of CAM exceeds two at the maximum secondary effluents if a safety factor of ten is considered. This suggests a possibility of algal growth inhibition due to CAM in WWTP discharge in the case of insufficient dilution of the receiving waters.
著者
田中 宏明 山下 尚之 吉谷 純一 中田 典秀 八十島 誠
出版者
京都大学
雑誌
基盤研究(B)
巻号頁・発行日
2007 (Released:2007-04-01)

遊離体と抱合体のエストロゲンの前処理を簡易化し、回収率を大幅に改善させる分析法を開発した。2008年1月と9月の降雨時期に 英国テムズ川流域で調査を行った結果、E2 やグルンクロン酸抱合体のエストロゲンが放流水や河川水で検出され、合流式下水道越流水の影響が無視できないことが明らかとなった。また我国で検出されないEE2 が流入下水や下水処理水で検出された。グルクロン酸抱合体よりも硫酸抱合体が、またE2 やE1 よりもEE2 は分解が遅いことが実験で明らかとなった。