著者

矢沢 代四郎 田中 寛 片岡 英幸 北西 剛 大脇 成広 佐伯 満男

出版者

Japan Society for Equilibrium Research

雑誌

Equilibrium Research (ISSN:03855716)

巻号頁・発行日

vol.54, no.6, pp.496-504, 1995 (Released:2009-06-05)

参考文献数

11

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Two cases of horizontal eye movements disorders due to pontine lesions are reported and their clinical symptoms described. Case 1, a 52-year-old female, showed right lateral gaze paralysis together with right facial paralysis, vestibular dysfunction and scanning speech after surgery on an epidermoid cyst in the 4th ventricle. Case 2, a 56-year-old female, displayed right lateral gaze paralysis combined with right facial paralysis, vestibular dysfunction, right deafness and left hemiplegia following pontine hemorrhage. The right lateral gaze paralysis of both cases were analyzed and speculated to have resulted from combined disorders of the right abducens nucleus, the right PPRF (paramedian pontine reticular formation) and the right MLF (medial longitudinal fasciculus) in the pontine tegmentum.

著者

鈴木 幹男 北西 剛 山名 高世 北野 博也 矢澤 代四郎 北嶋 和智

出版者

Japan Otological Society

雑誌

Otology Japan (ISSN:09172025)

巻号頁・発行日

vol.8, no.5, pp.526-530, 1998-12-25 (Released:2011-06-17)

参考文献数

16

被引用文献数

1

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Several point mutations of mitochondrial DNA have recently been identified as a cause of hearing loss. In Japan, there are considerable number of patients with A-to-G mutations at nucleotide position 3243 and at 1555. We investigated the prevalence of these mutations in patients with hearing loss using polymerase chain reaction method (PCR). We identified 3243 point mutation in 2 of 72 patients (2.8%) and 1555 point mutation in one of 57 patients (1.8%). The clinical neuro-otologic findings in patients with point mutations were consistent with those previously reported. The number of patients examined was composed of 9% of a total in our outpatient clinic. Therefore, we estimated 0.4% of patients in our clinic have a point mutation at nucleotide position 3243 or 1555.