著者

原 宏和

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.127, no.8, pp.1199-1205, 2007-08-01 (Released:2007-08-01)

参考文献数

27

被引用文献数

4 4

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NF-E2-related factor-2 (Nrf2), a basic leucine zipper transcription factor, is involved in the expression of numerous detoxifying and antioxidant genes via the antioxidant response element (ARE). Keap1, a cytoplasmic protein, sequesters Nrf2 in the cytoplasm under normal conditions. Various stimuli, including electrophiles and oxidative stress, liberate Nrf2 from Keap1, allowing Nrf2 to translocate into the nucleus and to bind to the ARE. Recently, there is increasing evidence that compounds that stimulate the activation of the Nrf2-ARE pathway may become useful therapeutic drugs for neurodegenerative diseases associated with oxidative stress. Apomorphine (Apo), a dopamine D1/D2 receptor agonist, is used for clinical therapy of Parkinson's disease. On the other hand, Apo is a potent radical scavenger and has protective effects on oxidative stress-induced cell death. We previously reported that pretreatment of human neuroblastoma SH-SY5Y cells with Apo enhanced the protective effects. In addition, we have recently demonstrated that Apo stimulates the translocation of Nrf2 into the nucleus and the transactivation of the ARE. Our findings suggest that not only the function as a radical scavenger, but also the function as an Nrf2-ARE pathway activator may be involved in the neuroprotective effects of Apo on oxidative stress-induced neuronal cell death. In this review, our recent studies on the mechanism underlying Apo-induced neuroprotection are summarized.

著者

二宮 嘉行 栁原 宏和 吉本 敦

出版者

FORMATH研究学会

雑誌

FORMATH (ISSN:21885729)

巻号頁・発行日

vol.6, pp.43-56, 2007 (Released:2020-06-05)

参考文献数

15

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林分内の間伐効果・競合効果・成長パターンの異質性などを検知する問題では, 非正則モデルに基づく分析が必要となるが, それらの分析手法には通常の統計理論を適用することはできない. 状況や検証したい仮説により使用する非正則モデルは異なり, 今までの非正則モデルに基づく分析では, それらのモデルごとに性質が議論されてきた. しかしながら, 近年それらを統一的に扱う理論が発展されつつある. 本論文では, 非正則モデルの主である局所錘モデルにおける検定問題に注目し,通常の検定とどう異なるかを説明し, 林分成長分析におけるその必要性について検討する.

著者

足立 哲夫 原 宏和 平野 和行

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.27, no.4, pp.386-391, 2001-08-10 (Released:2011-03-04)

参考文献数

4

被引用文献数

2 2

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All students in the 4 th year at our university, perform 4 -week training in pharmaceutical health care practice (practical training in hospital pharmacy and community prescription pharmacy). We carried out a consciousness survey of 149 students who received training at a community prescription pharmacy. A questionnaire on the interest in community prescription pharmacy work revealed the reply, “the training arouse my interest” in 58% of the students who wish to work in hospital after graduation and in 60% of those who wish to work in pharmacies but only in 49% of those who wish to work at pharmaceutical companies and in 40% of those who wish to go graduate schools. Among the types of work of community prescription pharmacy, those that particularly arouse student interest were “home medical care”, “patient compliance instructions” and “patient reception”. Interest in patient compliance instruction was frequently observed in students who wish to work in hospitals, home medical care and the sale of OTC drugs in those who wish to work in pharmacies, and DI work in those who wish to go to graduate schools.Concerning the questions about the image of community prescription pharmacies (or the work performance), students who felt a strong attitude of pharmacists toward their work showed more interest in training in community prescription pharmacies. To enhance the students' consciousness of practical training in community prescription pharmacy, the contents of training should be improved by evaluating the training items students wish to learn and adjusting by classifying the pharmacies requested to accept students for training.

著者

吉本 敦 庄司 功 尾張 敏章 加茂 憲一 二宮 嘉行 木島 真志 庄司 功 加茂 憲一 尾張 敏章 柳原 宏和 二宮 嘉行 佐々木 ノピア 木島 真志

出版者

統計数理研究所

雑誌

基盤研究(A)

巻号頁・発行日

2010-04-01

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1992年の生物多様性条約採択以降、生態系保全政策のグローバルな影響への関心が高まっている。このような保全政策はある地域の政策が他の地域の生産活動に及ぼす影響を考慮しながら、地域レベルの生態系サービス(多次元的な財)の生産調整を行う必要がある。その結果、地域的あるいは国際的に効果的・効率的かつ実行可能な保全政策を展開することが可能となる。本研究では、トルコ、韓国、日本を中心に、森林資源から供与される多次元的な財の中で、特に生息地供与機能、侵略的外来種防止機能、美的景観供与機能を特定するモデルを開発し、森林資源・生態系管理に対する時空間最適化モデルの構築により、それら機能を定量的に明らかにした。