著者

森 健太郎 和田 孝次郎 大谷 直樹 長田 秀夫 戸村 哲 山本 拓史 中尾 保秋

出版者

一般社団法人 日本脳卒中の外科学会

雑誌

脳卒中の外科 (ISSN:09145508)

巻号頁・発行日

vol.42, no.2, pp.116-121, 2014 (Released:2014-06-26)

参考文献数

13

被引用文献数

1

---

Basilar artery and internal carotid paraclinoid aneurysms are still surgically challenging. We performed 31 clipping surgeries (basilar tip aneurysm 6, basilar artery-superior cerebellar artery aneurysm 8, and internal carotid aneurysm 17) via the extradural temporopolar approach. After the frontotemporal craniotomy, the meningo-orbital band was incised and the dura propria of the temporal lobe was peeled from the lateral wall of the cavernous sinus. The anterior clinoid process was removed extradurally. The distal dural ring and falciform ligament were incised for mobilization of the internal carotid artery and optic nerve. The temporal lobe was retracted posteriorly with the dura mater. The aneurysm clipping was performed through the relatively wide operative trajectory over the opened cavernous sinus. Postoperative outcome was modified Rankin Scale (mRS) 0 in 28 patients and mRS in three patients with visual deficits. No temporal lobe contusion occurred. The extradural temporopolar approach is a useful skull base technique for deeply situated aneurysms.

著者

苗代 弘 和田 孝次郎 魚住 洋一 小林 弘明 竹内 誠 長谷 公洋 川内 聡子 佐藤 俊一

出版者

一般社団法人 レーザー学会

雑誌

レーザー研究 (ISSN:03870200)

巻号頁・発行日

vol.40, no.4, pp.265, 2012 (Released:2020-07-16)

参考文献数

17

---

Positive behavioral improvement has been observed following transcranial near-infrared light therapy in humans with chronic traumatic brain injury and acute stroke. We first examined the effect of 808 nm laser diode irradiation on regional cerebral blood flow (rCBF) in mice. An 808 nm CW diode laser was applied to the hemisphere transcranially. Transcranial near-infrared laser irradiation increased rCBF by 30% compared to control value in mice. Near-infrared laser irradiation also provoked a significant increase in cerebral nitric oxide concentration. In the clinical setting, transcranial near-infrared lightemitting diode irradiation to the forehead in a patient with persistent vegetative state following head injury was done. rCBF showed focal increase of 20%, compared to the pre-treatment value. The patient showed some improvement in his neurological condition after light-emitting diode therapy. Transcranial near-infrared irradiation might increase rCBF with some improvement of neurological condition in patients. Further study is warranted.

著者

苗代 弘 魚住 洋一 佐藤 俊一 川内 聡子 小林 弘明 長田 秀夫 大谷 直樹 和田 孝次郎 都築 伸介 島 克司

出版者

一般社団法人 日本脳卒中学会

雑誌

脳卒中 (ISSN:09120726)

巻号頁・発行日

vol.32, no.6, pp.559-562, 2010-11-26 (Released:2010-12-03)

参考文献数

15

---

Objectives: It has been reported that near-infrared (NIR) laser irradiation is effective in cerebral ischemia. We examined the effect of 808 nm laser diode irradiation on CBF in mice. The potential of NIR laser irradiation in the treatment of cerebral ischemia was also investigated.Methods: Male C57BL/6J mice were used. An 808 nm CW diode laser was applied to the hemisphere transcranially. CBF was measured with a non-contact laser Doppler blood perfusion imager. We measured directly nitric oxide in the brain tissue during NIR laser irradiation. To confirm the effect of pretreatment by NIR laser irradiation, we conducted the 1.6 W/cm2 NIR laser irradiation to the hemisphere transcranially for 30 minutes before bilateral common carotid artery occlusion (BCCAO). The control mice were also subjected to BCCAO without pretreatment by NIR laser irradiation.Results: Transcranial NIR laser irradiation increased local CBF by 30% compared to control value in mice. NIR laser irradiation also provoked a significant increase in cerebral NO concentration. Pretreatment by NIR laser irradiation improved residual CBF following bilateral carotid occlusion in mice.Conclusions: Our data suggest that targeted increase of CBF is available by NIR laser irradiation and it is concerned in NOS activity and NO concentration. Besides, NIR laser irradiation may have a protective effect for transient ischemia.