著者
川又 達朗 刈部 博 土肥 謙二 苗代 弘 平林 秀裕 村上 成之
出版者
一般社団法人 日本脳神経外傷学会
雑誌
神経外傷 (ISSN:24343900)
巻号頁・発行日
vol.30, no.1, pp.21-29, 2007-12-27 (Released:2022-06-27)
参考文献数
24
被引用文献数
1

In order to clarify clinical characteristics of "traumatic" intracranial hypotension (TIH) treated in Japan, 100 Japanese articles were reviewed and compared to 201 foreign articles. The results revealed the features of TIH in Japan as follows; 1) prolific numbers of the reported cases (227 cases) (foreign cases; 15 cases), 2) high incidence (69%) of traffic accident as a cause of injury (foreign cases; 20%), 3) long periods from injury to diagnosis; more than 1 year in many cases, 4) CSF leakage from lumber regions in vast majority cases (foreign cases: cervicothoracic regions; 91%), 5) fewer cases (55%) showing postural headache (foreign cases; 86%), 6) fewer cases (49%) showing dural enhancement on Gd-MRI (foreign cases; 93%), 7) fewer cases treated conservatively (foreign cases; 71%), 8) high numbers of blood patch procedure per patient, 9) lower cure rate (22%) by blood patch procedure (foreign cases; 100%). These results suggest that the clinical entity of TIH treated in Japan differs from that treated in foreign countries.
著者
佐藤 俊一 川内 聡子 奥田 航 西館 泉 苗代 弘
出版者
安全工学会
雑誌
安全工学 (ISSN:05704480)
巻号頁・発行日
vol.55, no.6, pp.447-453, 2016-12-15 (Released:2016-12-15)
参考文献数
7

近年爆弾テロの頻発により,頭部爆傷(bTBI),とりわけ通常の画像診断で陰性所見であるにもかかわらず様々な高次脳機能障害を来す軽症頭部爆傷(mbTBI)の受傷者が急増し,世界的に大きな問題となっている.しかしmbTBI は病態や発生メカニズムに不明な点が多く,診断・治療法の研究は進んでいない.著者らは,レーザー誘起衝撃波(LISW)をラット頭部局所に適用するモデルを対象に各種リアルタイム診断を行い,mbTBI のメカニズム解明を進めている.これまで,全身性に大きな影響が出ない曝露条件においても,脳のLISW 適用部位において拡延性脱分極(SD)が発生し,その伝搬に伴って皮質内に低酸素血症が発生することがわかった.このとき乏血(血管収縮)も起き,低酸素血症と乏血は長時間持続 した.これらの現象が神経細胞変性を引き起こす可能性が考えられる.
著者
島 克司 加藤 裕 苗代 弘
出版者
日本蘇生学会
雑誌
蘇生 (ISSN:02884348)
巻号頁・発行日
vol.17, no.1, pp.6-12, 1998-04-20 (Released:2010-06-08)
参考文献数
30

頭部外傷に伴う二次的損傷としての低酸素の海馬に及ぼす影響を明らかにするために, ラット閉鎖性頭部外傷 (脳振盪) モデルを用いて, 興奮性および抑制性アミノ酸の役割を中心に, われわれの研究結果と最近の知見を概説した。特に, 軽症頭部外傷でも低酸素が二次的に負荷されると, 海馬CA3領域に限局して選択的脆弱性が認められることを指摘した。この発生機序として, 海馬における興奮性アミノ酸グルタミン酸の高度かつ長時間の増加と抑制性アミノ酸GABAとの不均衡さらにはそれら受容体の不均衡も関与している可能性を示した。
著者
苗代 弘 和田 孝次郎 魚住 洋一 小林 弘明 竹内 誠 長谷 公洋 川内 聡子 佐藤 俊一
出版者
一般社団法人 レーザー学会
雑誌
レーザー研究 (ISSN:03870200)
巻号頁・発行日
vol.40, no.4, pp.265, 2012 (Released:2020-07-16)
参考文献数
17

Positive behavioral improvement has been observed following transcranial near-infrared light therapy in humans with chronic traumatic brain injury and acute stroke. We first examined the effect of 808 nm laser diode irradiation on regional cerebral blood flow (rCBF) in mice. An 808 nm CW diode laser was applied to the hemisphere transcranially. Transcranial near-infrared laser irradiation increased rCBF by 30% compared to control value in mice. Near-infrared laser irradiation also provoked a significant increase in cerebral nitric oxide concentration. In the clinical setting, transcranial near-infrared lightemitting diode irradiation to the forehead in a patient with persistent vegetative state following head injury was done. rCBF showed focal increase of 20%, compared to the pre-treatment value. The patient showed some improvement in his neurological condition after light-emitting diode therapy. Transcranial near-infrared irradiation might increase rCBF with some improvement of neurological condition in patients. Further study is warranted.
著者
苗代 弘 魚住 洋一 佐藤 俊一 川内 聡子 小林 弘明 長田 秀夫 大谷 直樹 和田 孝次郎 都築 伸介 島 克司
出版者
一般社団法人 日本脳卒中学会
雑誌
脳卒中 (ISSN:09120726)
巻号頁・発行日
vol.32, no.6, pp.559-562, 2010-11-26 (Released:2010-12-03)
参考文献数
15

Objectives: It has been reported that near-infrared (NIR) laser irradiation is effective in cerebral ischemia. We examined the effect of 808 nm laser diode irradiation on CBF in mice. The potential of NIR laser irradiation in the treatment of cerebral ischemia was also investigated.Methods: Male C57BL/6J mice were used. An 808 nm CW diode laser was applied to the hemisphere transcranially. CBF was measured with a non-contact laser Doppler blood perfusion imager. We measured directly nitric oxide in the brain tissue during NIR laser irradiation. To confirm the effect of pretreatment by NIR laser irradiation, we conducted the 1.6 W/cm2 NIR laser irradiation to the hemisphere transcranially for 30 minutes before bilateral common carotid artery occlusion (BCCAO). The control mice were also subjected to BCCAO without pretreatment by NIR laser irradiation.Results: Transcranial NIR laser irradiation increased local CBF by 30% compared to control value in mice. NIR laser irradiation also provoked a significant increase in cerebral NO concentration. Pretreatment by NIR laser irradiation improved residual CBF following bilateral carotid occlusion in mice.Conclusions: Our data suggest that targeted increase of CBF is available by NIR laser irradiation and it is concerned in NOS activity and NO concentration. Besides, NIR laser irradiation may have a protective effect for transient ischemia.
著者
都築 伸介 大井川 秀聡 豊岡 輝繁 魚住 洋一 長田 秀夫 鈴木 隆元 宮澤 隆仁 苗代 弘 島 克司
出版者
一般社団法人 日本脳卒中の外科学会
雑誌
脳卒中の外科 (ISSN:09145508)
巻号頁・発行日
vol.37, no.5, pp.375-378, 2009 (Released:2010-04-16)
参考文献数
4

A 74-year-old man presented with subarachnoid hemorrhage (SAH) and underwent neck clipping of a left middle cerebral artery (MCA) aneurysm 10 years ago. This patient presented with SAH again due to rupture of a de novo aneurysm of the anterior communicating artery (A-com. aneurysm). The A-com. aneurysm was clipped successfully. The “old” left MCA aneurysm was then inspected. A collapsed “old” aneurysmal dome and a previously applied clip were identified. The “old” aneurysmal dome was resected for histopathological examination. The wall of this aneurysmal dome varied in thickness and consisted of a thin layer of fibrous connective tissue. Fibroblasts were scattered in the aneurysmal wall and either the muscular layer or internal elastic lamina was absent. The aneurysmal dome collapsed to a certain degree, but the lumen of the dome was completely intact. In addition, neovascularization of microcapillaries was observed both inside and outside the aneurysmal dome. Some of these microcapillaries were filled with fresh erythrocytes. Thus the aneurysmal wall was apparently “vigorous.” The previous orifice of the aneurysm did not fuse together at all and could be opened widely with ease during preparation for histopathologic examination. We speculated that the clipped aneurysmal dome survived for 10 years for the following reasons: 1) Although the mechanism of neovascularization of the microcapillaries is unclear, the clipped aneurysmal dome may have obtained nourishment from the microcapillaries. 2) The cerebrospinal fluid may have incubated the dome and provided optimal circumstances for its survival. Considering the radical cure for ruptured cerebral aneurysms by neck clipping or coil embolization, the findings described in this report will be valuable for neurosurgeons and neurointerventionists. Regardless of the time since treatment, ruptured aneurysms treated by either neck clipping and/or coil embolization are at risk of recurrent subarachnoid hemorrhage when the blood re-enters the aneurysms in cases such as clip slip-off or coil compaction.
著者
佐藤 俊一 川内 聡子 奥田 航 西舘 泉 苗代 弘
出版者
Japan Society for Laser Surgery and Medicine
雑誌
日本レーザー医学会誌 (ISSN:02886200)
巻号頁・発行日
vol.35, no.2, pp.132-139, 2014

近年,爆弾テロの多発により爆風による頭部外傷(blast-induced traumatic brain injury, bTBI)の受傷者が急増している.しかしbTBI は病態,メカニズムに不明な点が多く,診断・治療技術は確立していない.我々はラット頭部にレーザー誘起衝撃波(laser-induced shock wave, LISW)を適用するモデルを対象に各種リアルタイム診断を行った.その結果,全身性生理学パラメーターに著明な変化が無く,大脳皮質において出血や挫傷がごく限定的な条件においても,拡延性脱分極,持続性の血管収縮,乏血・低酸素血症等が発生することが明らかになった.