著者

澤井 秀次郎 坂井 真一郎 坂東 信尚 丸 祐介 永田 晴紀 後藤 健 小林 弘明 吉光 徹雄

出版者

国立研究開発法人宇宙航空研究開発機構

雑誌

基盤研究(A)

巻号頁・発行日

2013-05-31

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空気吸込式エンジンを用いるスペースプレーンの実現に向けて,飛行実証を通して基盤となる技術を獲得するために,気球による高高度からの落下と小型ロケットブースターによる加速を組み合わせた高速飛行実証システムの構築を目指した.飛行軌道検討を主としたシステム概念検討を行った.その結果を踏まえ,飛行実験機の試作研究を行った.試作研究を通して,システム統合および飛行制御系技術の実践研究を行った.さらに,スペースプレーンに必要な技術として,空力設計技術の研究を行った.実験オペレーションまで想定した実験計画を検討し,本システムのメリットに加え,課題も整理した.

著者

橋本 樹明 澤井 秀次郎 斎藤 芳隆 稲富 裕光 石川 毅彦 小林 弘明 坂井 真一郎 山川 宏 吉光 徹雄 斎藤 芳隆 石川 毅彦 稲富 裕光 澤井 秀次郎 坂井 真一郎 吉光 徹雄 小林 弘明 藤田 和央 坂東 信尚 山川 宏

出版者

独立行政法人宇宙航空研究開発機構

雑誌

学術創成研究費

巻号頁・発行日

2004

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数十秒間の微小重力環境を中程度のコストで実現する手段として、高高度気球から微小重力実験装置を落下させ、自由落下中に微小重力実験を実施するシステムを開発した。飛翔実験にて10^<-4>G以下の微小重力環境を約35秒間実現し、今後の定常的運用に目処を立てた。

著者

淺井 知宏 三橋 晃 林 誠 坂東 信 古澤 成博 前田 英史

出版者

一般社団法人 日本歯内療法学会

雑誌

日本歯内療法学会雑誌 (ISSN:13478672)

巻号頁・発行日

vol.42, no.3, pp.166-173, 2021 (Released:2021-10-15)

参考文献数

25

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Abstract : Purpose : In 2003, a study was conducted in Japan on the use of a rubber dam during endodontic treatment. As a result, 25.4% of the Japan Endodontic Association (JEA) member group and 5.4% of the general dentists group (JEA non-member group) answered that they routinely use it. On the other hand, with the increasing interest in preserving teeth among Japanese people in recent years, interest in endodontic treatment has increased too, and the equipment and materials used have also made great progress. Therefore, we hypothesized that the frequency of use of a rubber dam might have changed, and examined it in this study. Materials and Methods : The study period was from October 2019 to November 2020, and questionnaires were conducted through workshops and seminars, etc. held by the JEA, and the Internet. The recovery rate of questionnaires was 97.5%, and responses were received from a total of 986, including 463 in the JEA member group, 100 in the endodontist/dental clinical instructor group of the Japan Endodontic Association (JEA endodontist group), and 523 in the JEA non-member group. Results and Discussion : As a result of the questionnaire, 51.5% of the JEA member group, 60.0% of the JEA endodontist group, and 14.1% of the JEA non-member group answered that they would routinely use a rubber dam. The percentages who use it on a daily basis were : 74.0%, 81.1%, and 28.6%, respectively. In addition, 65.3%, 61.1%, and 34.8% of these three groups answered that they would perform pre-endodontic build-up when necessary for root canal treatment. The JEA member group and the JEA endodontist group were aware of the necessity of the rubber dam isolation technique and pre-endodontic build-up, but the JEA non-member group seemed to have a low usage rate due to complexity and economic reasons. Conclusion : Compared to the 2003 study, it was revealed that the frequency of rubber dam use had increased significantly in both the JEA member group including the JEA endodontist group, and the non-JEA member group. In addition, more than half of the JEA member group and JEA endodontist group routinely perform pre-endodontic build-up, and one third in the non-JEA member group also perform it, suggesting increasing awareness of the importance of using a rubber dam in endodontic treatment.

著者

松永 康志 大田 涼子 坂東 信行 山田 博章 湯浅 宏 金谷 芳雄

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.41, no.4, pp.720-724, 1993-04-15 (Released:2008-03-31)

参考文献数

10

被引用文献数

6 13

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(E)-4-[1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-(4-isopropyl)phenyl]-1-butenyl]phenyl monophosphate (TAT-59) is a new drug for the treatment of breast cancer. Physical and chemical stability of a tablet consisting of TAT-59 powder and a few excipients (Formulated tablet), a tablet consisting of only TAT-59 power (TAT-59 tablet) and TAT-59 powder itself itself was evaluated based on water content, tensile strenght, porosity, the amount of TAT-59 and its hydrolysis product, DP-TAT-59.The water content of Formulated tablet increased with relative humidity (RH), whereas that of TAT-59 tablet and TAT-59 powder scarcely changed. The equilibrium water content of Formulated tablet was much greater than that of the TAT-59 tablet or TAT-59 powder due to adsorbed moisture by the excipients. The tensile strength and porosity of Formulated tablet decreased and increased linearly, respectively, with increasing water content. The degradation rate of TAT-59 decreased in the following order : Formulated tablet>TAT-59 tablet>TAT-59 powder. The relationship between equilibrium water content and degradation rate of the Formulated tablet was determined by the Carstensen equation, in which the interaction order between the durg and water content was 1.9, and the degration of TAT-59 in Formulated tablet was related to water content. Thus, it was found that the degradation of TAT-59 was accelerated by compression and addition of excipients.