著者
丸川 恵理子 吉田 文彦 宮崎 英隆 櫻井 仁亨 石井 良昌 小村 健
出版者
公益社団法人 日本口腔外科学会
雑誌
日本口腔外科学会雑誌 (ISSN:00215163)
巻号頁・発行日
vol.56, no.5, pp.323-327, 2010-05-20 (Released:2013-10-19)
参考文献数
17

The initial symptoms of leukemia include oral manifestations such as gingival hemorrhage and swelling. In patients with these symptoms, attention should be paid to the early diagnosis of acute leukemia. This report describes three cases of acute myelogenous leukemia (AML) with initial manifestations in the oral cavity.Patient 1: A 32-year-old woman. Ulcer lesions of the oral mucosa were diagnosed as decubital ulcers, and symptoms did not respond to the application of steroid ointment. She also had appetite loss, general malaise, and bloody stools. Blood examination showed a low white-cell count (1,600/μl).Patient 2: A 52-year-old man. He received anti-inflammatory treatment and had pain at the mandibular third molar region and gingival swelling, but the symptoms did not improve. At the initial visit, pericoronitis of the mandibular third molar with fever and general malaise were observed. Blood examination showed a low white-cell count (2,300/μl) and remarkably increased myeloblasts (20 %) .Patient 3: A 54-year-old woman. She received medication to treat full-mouth gingival swelling. However, fever and general malaise persisted. Blood examination showed a high white-cell count (47,000/μl).All three patients were given a diagnosis of AML on bone marrow biopsy.When the patients present with oral symptoms such as gingival swelling and ulcers accompanied by fever and general malaise, blood examinations should be promptly performed for the differential diagnosis of acute leukemia.
著者
工藤 敏文 井上 芳徳 地引 政利 豊福 崇浩 横尾 聡 宮崎 英隆
出版者
東京医科歯科大学
雑誌
基盤研究(C)
巻号頁・発行日
2012-04-01

末梢動脈疾患(PAD)がある患者の下肢の局所循環を評価することは重要である。PADは下肢切断も免れない重症虚血を招きやすく、このため血行再建を必要とするのか否かをある一定の基準から決定することが肝要である。本研究において、PAD、特に下腿・足部潰瘍が多く認められる重症虚血肢の局所(末梢)循環に対して、新たな局所(末梢)循環の計測法の開発およびより詳細なアンギオサムの解明を行った。