著者

広瀬 統 田中 浩 岡田 富雄 小西 宏明

出版者

The Society of Cosmetic Chemists of Japan

雑誌

日本化粧品技術者会誌 (ISSN:03875253)

巻号頁・発行日

vol.23, no.1, pp.5-8, 1989-06-25 (Released:2010-08-06)

参考文献数

14

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The purpose of this study was to investigate the incidence of parakeratotic stratum corneum cells on the cheek skin surface from 335 healthy subjects and the changes of them according to their ages. We also studied the quantitative levels of parakeratotic cells in various regions of face. Stratum corneum cells were collected by tape-stripping method and observed with hematoxyrin-eosin stain after formalin fixation.In our results, parakeratotic cells were observed in 68.4% of the total subjects, 64.4% of them were women and 72.7% of them were men. They were observed at about 80% in second and third decades of women and decreased as the age advanced. On the other hand, they were observed at about 80% after the first decade in men.Quantity of parakeratotic cells was the highest in upper cheek and followed by the forehead and nose. They were seldom observed below the cheek and chin.It was suggested that the parakeratotic cells were appeared in the stratum corneum cells in face, because our facial skin is always exposed to many external stimulations such as ultraviolet rays and so on and turn over of epidermis was accelerated. Moreover, we strongly suggested that sebum is one of the factor causing parakeratosis. Because parakeratotic cells were observed more frequently in the region where sebum level was high and most of them were observed around the pore of the hairs.Appearance of parakeratotic cells on skin surface implied the loss of skin barrier function and was important problem to the beauty and healthinèss of skin.

著者

岡田 富雄 浅井 淳平 飯島 宗一 早川 律子 田中 隆義 大橋 勝

出版者

日本皮膚科学会大阪地方会

雑誌

皮膚 (ISSN:00181390)

巻号頁・発行日

vol.22, no.3, pp.378-382, 1980 (Released:2010-06-04)

参考文献数

8

被引用文献数

1

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飽和炭化水素であるスクワランに長期紫外線照射すると, 経時的にTBA値が上昇し, その紫外線照射スクワランをモルモットの皮膚に繰り返し塗布すると明らかな紅斑が生じ, 血管透過性が亢進した。組織学的には, 表皮におけるacanthosig, hyperkeratosis, 基底細胞層の一部に空胞変性, exocytosisが見られ, 真皮上層では好中球を主体とした細胞浸潤と中等度の血管拡張がみられた。超微形態学的には, 表皮基底細胞においてミトコンドリアの膨化, 拡大した細胞間隙に細胞成分の残渣が浮遊している像がみられた。また, この紫外線照射スクワランをGLC, TLCを用いて分析した結果, 紫外線照射によって新たに生じた二次産物は過酸化物であることが確認された。