著者

二神 幸次郎 西原 茂樹 定金 典明 谷口 律子 荒木 博陽 川崎 博巳 五味田 裕

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.27, no.6, pp.589-593, 2001-12-10 (Released:2011-03-04)

参考文献数

4

被引用文献数

5 5

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During a three-week long practical training program for pharmacy students at our hospital, senior pharmacy students had a one-day observation of pharmacists performing new drug investigations. Using a questionnaire survey we investigated whether the observation of the work of clinical research coordinator (CRC) influenced the student's understanding of the new drug investigation procedures. The observation of CRC's work consisted of counseling/interviewing prior to the doctor's consultation and visiting a clinical laboratory to observe new drug investigations. The items evaluated were impressions of the clinical investigation of new drugs, precautions for preparing investigational drugs, understanding the new Good Clinical Practice (GCP) guidelines and other important aspects in the clinical investigation. Each group consisted of 26 students. Only 10 out of 26 students observed counseling/interviewing before the doctor's consultation with CRC. The impression of the clinical investigation procedure in group I, which observed the CRC's work was more favorable than in group II, which did not observe it. The understanding of the important aspects of the clinical investigation procedures in group I was markedly better than in group II. We thus consider that the observation of the CRC work is very useful for students not only to learn new drug investigation procedures, but also to understand the meaning of the new GCP guidelines.

著者

塩尻 容子 黒崎 勇二 川崎 博巳 柳澤 一恵 荒木 博陽 五味田 裕 小田 慈 竹田 芳弘 平木 祥夫

出版者

一般社団法人 日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.24, no.6, pp.677-682, 1998-12-10 (Released:2011-08-11)

参考文献数

14

被引用文献数

1 3

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Improving the patient's QOL is an important matter for guaranteeing proper pharmacotherapy. Lugol's solution (LS, iodine content: I2 3.4%, KI 6.6%) for internal use is a useful drug for the inhibition of radioiodine uptake to the thyroid gland. However, it is difficult for patients, especially children to take this agent or ally due to its unpleasant taste, terrible smell, and peculiar color. The present study was conducted to improve both the taste and the smell of LS, by using soft drinks containing ascorbic acid. Iodine (I2) molecules in LS are reduced to iodide (F) by ascorbic acid, and the peculiar color of LS thus vanished. The amount of L (+)-ascorbic acid (VC) required to remove the color was in good agreement with the rational value. The improvement in the taste, smell, stimulation on the tongue, and the overall ease in taking the following four LS preparations, i.e., the control LS (LS-I), added by Simple Syrup solution (LS-II), by VC solution (LS-III), and by POCARISWEAT® (LS-IV), were then evaluated in the ten healthy adult volunteers. LS-II, -III and -IV, significantly improved all the elements compared with LSI, and eight volunteers selected LS-IV as the easiest preparation. The inhibitory effect of LS-IV to the radioiodine uptake to the thyroid gland was also confirmed in a patient with neuroblastoma based on a clinical diagnosis using 131I-metaiodobenzyl-guanidine scintigraphy. These results suggest that the medication method for taking LS with soft drinks containing VC improves the compliance and QOL of these patients.

著者

川上 英治 二神 幸次郎 定金 典明 西原 茂樹 荒木 博陽 川崎 博巳 五味田 裕

出版者

日本医療薬学会

雑誌

病院薬学 = Journal of the Nippon Hospital Pharmacists Association (ISSN:03899098)

巻号頁・発行日

vol.25, no.1, pp.69-75, 1999-02-10

被引用文献数

8

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Pharmacists need to have a clear policy for managing investigational drugs under circumstances that are consistent with Good Clinical Practice. We studied the management and support system for the clinical research of investigational drugs based on the management of investigational drugs. We experienced 126 cases of pharmaceutical consultations in 650 prescriptions for investigational drugs from April 1997 to March 1998. Seven cases which might induce a patient to drop out, were included in pharmaceutical consultations. We found it was important to communicate with all investigators regarding giving adequate prior information to having a clearly defined protocol. Our pharmaceutical program for the clinical research of investigational drugs was thus found to be useful in the management of investigational drugs.