著者

日野 美波理 石井 雅人 藤原 聡子 松香 直行 定金 典明 森山 雅弘 二神 幸次郎 柴田 和彦 五味田 裕

出版者

日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.30, no.7, pp.457-467, 2004-07-10

被引用文献数

7 7

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Owing to the approval of reimbursement of fees for antineoplastic chemotherapy on an outpatient basis by the national health insurance scheme in April 2002, an antineoplastic chemotherapy room was set up in the ambulatory area of our hospital in August 2000. In order to ensure the effective use of the safety cabinet and other existing equipment and the safe administration of antineoplastic agents to patients, the authors assigned a mixing pharmacist and a coordinating pharmacist who was to be in charge of antineoplastic chemotherapy for outpatients. First, the mixing pharmacist prepared IV mixtures of the antineoplastic agents and auxiliary medicines in a sterile area and then the coordinating pharmacist audited the mixtures and carried them to the antineoplastic chemotherapy room. Other functions of the coordinating pharmacist included providing pharmaceutical care to patients and cooperating with doctors, nurses and other pharmacists involved in the chemotherapy. They also searched for information on individual medical charts or in patient statements and pointed out doubtful records or potential problems that might affect chemotherapy. Coordinating pharmacists notified 50 potential problems between August 2002 and April 2003. To evaluate our pharmaceutical practices in outpatient antineoplastic chemotherapy, we conducted a questionnaire survey of the patients. Their responses indicated that our pharmaceutical care program was working well and that they hoped we would continue it. However, the usefulness of our program was not entirely clear to all patients and we recognized the need to better inform patients concerning this.

著者

簔原 豪人 内山 将伸 緒方 憲太郎 二神 幸次郎

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.37, no.11, pp.649-652, 2011 (Released:2012-11-10)

参考文献数

11

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Using a formula for calculating the glomerular filtration rate (GFR) for Japanese announced in 2009, individual patients' GFRs can be predicted by inversely correcting the formula with body surface area. In this study, we investigated the influence of the dissociation between the GFR normally employed to calculate the dose and inversely corrected GFR on carboplatin (CBDCA)-related thrombocytopenia. In a group with grade 3 or higher thrombocytopenia, the dissociation between the GFRs used to calculate the dose of CBDCA was significantly greater. Also, in an analysis of thrombocytopenia-related factors, including concomitant anti-cancer agents, the only significant difference was that regarding GFR dissociation.These results suggest that the introduction of the inversely corrected GFR for accurate calculation of the GFR and setting of CBDCA doses is useful in decreasing the incidence of serious thrombocytopenia.

著者

二神 幸次郎 定金 典明 西原 茂樹 三牧 祐一 荒木 博陽 五味田 裕

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.28, no.6, pp.630-636, 2002-12-10 (Released:2011-03-04)

参考文献数

5

被引用文献数

2 2

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Our hospital established a Center for Clinical Research of New Drugs and Therapeutics in April 1999. The Center consists of 6 departments : i.e. departments which help to coordinate clinical research, which help to manage the investigated drugs, preview clinical research study protocols, coordinate clinical research, educate research staff and support clinical research at other medical institutions. Pharmacists are involved in all 6 departments of the Center and have been playing various roles. Under this situation, the Institutional Review Board (IRB) started to review investigator-initiated clinical research on drugs, regarding the study protocol, written information (IC) for trial subjects and other information about the drugs beginning in January 2000. All research was performed according to the new Good Clinical Practice, but studies were initiated without providing sufficient compensation in cases of severe adverse drug reactions. The IRB reviewed thirty-four clinical research protocols from January 2000 to December 2001 and an average of 1.5 cases were reviewed by the IRB per meeting. The average reviewing time was 28 minutes (max. 68 minutes). Sixteen, eight, eight and two protocols of clinical research involved Phase III, I/II and II trials and medical instruments, respectively. Considerable clinical research has been performed by such departments as Internal Medicine I, II and Urology, in particular.We recognized that considerable clinical research has been performed with unapproved drugs at our hospital. After the IRB review, pharmacists played various important roles, e.g. dispensing test drugs, preparing some manufactured drugs and confirming the written informed consent. However, up to now the clinical research coordinator (CRC) has not sufficiently supported these studies. The CRC should thus support this research by improving the quality of these studies and the safety performance for patients.

著者

小金 一恵 二神 幸次郎 岡崎 昌利 谷口 律子 荒木 博陽 五味田 裕

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.28, no.6, pp.599-604, 2002-12-10 (Released:2011-03-04)

参考文献数

6

被引用文献数

2 1

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We have recently instituted an audit system with the goal of maintaining and improving quality in pharmaceutical management and counseling services, i.e., pharmaceutical care practices. This system was created to improve the quality of record keeping for counseling services. The audit system is composed of 5 supervising pharmacists. A meeting is held once a month, and an audit is carried out concerning the patient compliance instruction documents, medication history and practice records of 2 clinical departments. In addition, methods for improving business efficiency are also discussed. We herein report on the specific guidance given to the supervising pharmacists of each clinical department, based on a total of 12 audit conferences. As a result, four problems were identified : (1) fundamental description issues, (2) record keeping modes, (3) insurance demands, (4) pharmaceutical perspective. The following improvements were instituted after notifying the relevant pharmacists and all other pharmacy staff of these problems : a reduction in the leakage of specific items, corrections of the records explaining the pharmacological effects, establishment of a drug interaction checklist, simplification of laboratory data records, simplification of the format, utilization of a problem list field, and other issues. The role of this audit system in maintaining and improving the quality of pharmaceutical management and counseling services has become increasingly important because as the counseling services for patients continue to expand.

著者

二神 幸次郎 西原 茂樹 定金 典明 谷口 律子 荒木 博陽 川崎 博巳 五味田 裕

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.27, no.6, pp.589-593, 2001-12-10 (Released:2011-03-04)

参考文献数

4

被引用文献数

5 5

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During a three-week long practical training program for pharmacy students at our hospital, senior pharmacy students had a one-day observation of pharmacists performing new drug investigations. Using a questionnaire survey we investigated whether the observation of the work of clinical research coordinator (CRC) influenced the student's understanding of the new drug investigation procedures. The observation of CRC's work consisted of counseling/interviewing prior to the doctor's consultation and visiting a clinical laboratory to observe new drug investigations. The items evaluated were impressions of the clinical investigation of new drugs, precautions for preparing investigational drugs, understanding the new Good Clinical Practice (GCP) guidelines and other important aspects in the clinical investigation. Each group consisted of 26 students. Only 10 out of 26 students observed counseling/interviewing before the doctor's consultation with CRC. The impression of the clinical investigation procedure in group I, which observed the CRC's work was more favorable than in group II, which did not observe it. The understanding of the important aspects of the clinical investigation procedures in group I was markedly better than in group II. We thus consider that the observation of the CRC work is very useful for students not only to learn new drug investigation procedures, but also to understand the meaning of the new GCP guidelines.

著者

矢野 育子 井関 健 東海林 徹 青山 隆夫 木津 純子 中村 均 藤井 俊志 渡邊 美智留 野田 幸裕 脇屋 義文 森田 邦彦 手嶋 大輔 二神 幸次郎

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.35, no.1, pp.43-49, 2009 (Released:2010-02-07)

参考文献数

8

被引用文献数

1 1

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With the introduction of 6-year pharmacy educational program in 2006,a provision was made to assign pharmacist faculties having working experience as pharmacists in pharmacy schools.In October 2007,we conducted a survey to investigate the situation of pharmacist faculties.We sent a questionnaire to 247 pharmacist faculties in 66 pharmacy schools and the response rate was 84.9%.The faculties consisted of professors (43%),associate professors (23%) and lecturers (23%),and 77% of them had a Ph.D.degree.In a typical week,the major activities they engaged in were educational activities (20.6 hrs),research (12.2 hrs) and management (9.6 hrs).While the average time they were occupied by clinical practice was 3.5 hrs,67% of them did not do any.Half of the faculties did not conduct any research with students or graduate students in their own schools,and in 2007 only 55% applied for Grant-in-aid for Scientific Research from the Ministry of Education,Culture,Sports,Science and Technology of Japan.Twenty-six percent said they were very satisfied or satisfied with their work on a five-point scale,and 44% rated their degree of satisfaction as fair.In conclusion,our survey showed that most pharmacy faculties are not sufficiently engaged in clinical practice and do not spend much time in clinical research.We hope that its results will promote discussions among pharmacy personnel concerning the role of pharmacist faculties so that even better clinical pharmacy education may be provided to students in pharmacy schools.

著者

上野 雅代 前原 加奈子 吉住 亜紀子 池内 忠宏 真島 宏太 山本 知佳 DennisM. Williams 二神 幸次郎

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.34, no.9, pp.882-890, 2008 (Released:2010-02-07)

参考文献数

16

被引用文献数

3

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Smoking is a risk factor for pulmonary diseases,cardiovascular diseases and many other morbid conditions but it is difficult to get patients to cease smoking due to the strength of nicotine dependence.As one of our pharmaceutical management and counseling services,we conducted a smoking cessation intervention program for inpatients in which we counseled them on the proper use of nicotine replacement products using a smoking cessation guidebook,and evaluated the usefulness of such counseling.We interviewed 228 patients and from among them enrolled 18 current smokers and 11 people who had stopped smoking during the past 30 days as subjects.The content of the program was evaluated through a questionnaire survey of patients and the success of the counseling by pharmacists was evaluated by smoking cessation status at discharge.Immediately after the program,44.4% of the smokers had ceased smoking and this figure had increased to 83.3% at the time of discharge.All subjects who had stopped smoking during the past 30 days continued to refrain from smoking until discharge.The results of the questionnaire survey showed that the use of a smoking cessation guidebook in the intervention enhanced awareness of the importance of ceasing smoking in 89.7% of the subjects.Though they were frequently made aware of nicotine replacement products,only about 10% had wished to use them.The findings of the questionnaire survey suggest that our smoking cessation intervention program for inpatients involving counseling on the proper use of nicotine replacement products improved patients’awareness of the importance of smoking cessation and reduced the smoking rate.

著者

川上 英治 二神 幸次郎 定金 典明 西原 茂樹 荒木 博陽 川崎 博己 五味田 裕

出版者

一般社団法人 日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.25, no.1, pp.69-75, 1999-02-10 (Released:2011-08-11)

参考文献数

7

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Pharmacists need to have a clear policy for managing investigational drugs under circumstances that are consistent with Good Clinical Practice. We studied the management and support system for the clinical research of investigational drugs based on the management of investigational drugs. We experienced 126 cases of pharmaceutical consultations in 650 prescriptions for investigational drugs from April 1997 to March 1998. Seven cases which might induce a patient to drop out, were included in pharmaceutical consultations. We found it was important to communicate with all investigators regarding giving adequate prior information to having a clearly defined protocol. Our pharmaceutical program for the clinical research of investigational drugs was thus found to be useful in the management of investigational drugs.

著者

緒方 憲太郎 猪狩 洋介 原 周司 石津 昌直 高松 泰 田村 和夫 二神 幸次郎

出版者

日本医療薬学会

雑誌

日本医療薬学会年会講演要旨集

巻号頁・発行日

vol.22, 2012-10-10

著者

川上 英治 二神 幸次郎 定金 典明 西原 茂樹 荒木 博陽 川崎 博巳 五味田 裕

出版者

日本医療薬学会

雑誌

病院薬学 = Journal of the Nippon Hospital Pharmacists Association (ISSN:03899098)

巻号頁・発行日

vol.25, no.1, pp.69-75, 1999-02-10

被引用文献数

8

---

Pharmacists need to have a clear policy for managing investigational drugs under circumstances that are consistent with Good Clinical Practice. We studied the management and support system for the clinical research of investigational drugs based on the management of investigational drugs. We experienced 126 cases of pharmaceutical consultations in 650 prescriptions for investigational drugs from April 1997 to March 1998. Seven cases which might induce a patient to drop out, were included in pharmaceutical consultations. We found it was important to communicate with all investigators regarding giving adequate prior information to having a clearly defined protocol. Our pharmaceutical program for the clinical research of investigational drugs was thus found to be useful in the management of investigational drugs.

著者

芝口 浩智 山本 知佳 黒木 政秀 二神 幸次郎

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.130, no.7, pp.977-982, 2010 (Released:2010-07-01)

参考文献数

13

被引用文献数

1 4

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Cytomegalovirus (CMV) remains the most important pathogen following solid organ transplantation and is the major cause of recipient morbidity and mortality during the first 6 months posttransplantation. To prevent CMV infection and/or to prevent symptomatic CMV disease, immunoglobulin (Ig) G including hyperimmune CMV IgG are used alone or in combination with antiviral medications. The CMV IgG titer, however, has a wide range and frequently depends on the company supplying the Ig preparation even if the preparations come from the plasma pool of a national blood donation agency. In the present study, we therefore simultaneously measured and evaluated the CMV IgG titers in various Ig preparations using two common methods: the neutralizing antibody (NT) and enzyme immunoassay (EIA). The CMV IgG titer in the present study indicated different values using both methods among Ig preparations that were made from the plasma pool of a national blood donation agency (about 3.5- or about 1.7-fold difference using the NT or EIA methods, respectively). Furthermore, there were no correlations in the CMV IgG titer between our findings and published data from the manufacturers, or between the two methods tested here. These findings suggest the importance and necessity of a standard method and/or sample for the measurement and assessment of CMV IgG in Ig preparations.

著者

吉山 友二 尾鳥 勝也 厚田 幸一郎 矢後 和夫 藤金 治雄 緒方 憲太郎 二神 幸次郎

出版者

日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.33, no.4, pp.365-369, 2007-04-10

被引用文献数

2

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Elcatonin injection is used for the treatment of osteoporosis in Japan. In order to compare the original product with generic versions, we measured the elcatonin content and amounts of impurities in both using high performance liquid chromatography, and observed changes in content with time under the conditions of light exposure and shaking. We found that elcatonin content and amounts of impurities varied among the generics and that changes in content with time under the above conditions for some generics were greater than the changes for the original product. These results suggest that some generic products should not be considered to be equivalent to the original product.