著者

徳増 厚二 長沼 英明 橋本 晋一郎 伊藤 昭彦 和田 昌興 岡本 牧人 山根 雅昭

出版者

一般社団法人 日本めまい平衡医学会

雑誌

Equilibrium Research (ISSN:03855716)

巻号頁・発行日

vol.66, no.2, pp.64-72, 2007 (Released:2008-10-10)

参考文献数

17

---

Hyperosmotic solution of isosorbide has been used for treatment of Meniere's disease since Kitahara et al., Larsen et al. and Nozawa et al.. In recent studies reported that ADH is acting to open water channels, AQP-2 at the endlymphatic membrane and may act worse for labyrinthine hydrops. It is important the serum concentration of isosorbide after administration because ADH should be released if the serum osmotic pressure is elevated by isosorbide above more than 2% of normal serum osmotic pressure. In this study the equation predicting isosrbide serum concentration after oral administration was proposed on the basis of the data by Wakiya's report. It was confirmed the serum osmotic pressure remains below the threshold level for increasing ADH secretion by the routine method of 30 ml/once, 3 times every day. However, the method of 30 ml/once, single or two times every day should be recommended when the serum osmotic pressure before the medication is above 289 mOsm/kg.

著者

長沼 英明 河原 克雅 徳増 厚二 和田 昌興 上条 貴裕 岡本 牧人

出版者

一般社団法人 日本聴覚医学会

雑誌

AUDIOLOGY JAPAN (ISSN:03038106)

巻号頁・発行日

vol.49, no.5, pp.599-600, 2006-09-05 (Released:2010-08-05)

著者

稲木 勝英 設楽 哲也 岡本 牧人 徳増 厚二 藤野 明人 石井 豊太 鎌田 利彦

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.82, no.4, pp.537-541, 1989-04-01 (Released:2011-11-04)

参考文献数

12

被引用文献数

2 2

---

Aortitis syndrome is known to be an autoimmune disease, which has many symptoms of occulusive thromboaortopathy. It has recently been reported that the patients with systemic autoimmune diseases may have sensorineural hearing loss and that steroid therapy should be effective not only for the original disorder but also for the associated hearing disturbance.Eleven patients (3 males and 8 females) with aortitis syndrome and sensorineural hearing loss have been treated in Kitasato University Hospital during the 16 years since the opening of the hospital.The onset of hearing impairment was at 32 to 48 years of age, 10 years older than the mean age of onset of the aortitis syndrome reported in the literatures.Various types of hearing impairment were noted : slight hearing loss, total deafness of sudden onset and fluctuating type. Tinnitus was associated with hearing loss in many cases.Several patients also had vertigo and dysequilibrium, and in some of them the diagnosis was peripheral vestibular hearing loss, although in the cases of aortitis syndrome with hearing loss reported in the literature neither vertigo nor dizziness was mentioned.The usual treatment for acute stage sudden deafness was not effective in most of our patients. However, one female patient treated with long-term steroid therapy for systemic arteritis showed marked improvement of both her hearing and her general condition.We cannot conclude that the origin of sensorineural hearing loss is arteritis in the inner ear in all cases of aortitis syndrome with hearing loss. However, our cases of aortitis syndrome with steroid-dependant hearing loss indicate that the possibility remains of hearing loss due to arteritis of the labyrinthine artery in aortitis syndrome.

著者

長沼 英明 設楽 哲也 徳増 厚二 岡本 牧人 平山 方俊

出版者

日本耳科学会

雑誌

Otology Japan (ISSN:09172025)

巻号頁・発行日

vol.1, no.5, pp.44-48, 1991-12-20 (Released:2011-06-17)

参考文献数

20

---

Frequently encountered are cases of perforated ear drum, for whom there is no opportunity of myringoplasty or operation to repair the perforation, owing to work or school. A new method of myringoplasty by intrameatal approach without skin incision and using a homograft of temporal fascia in an outpatient should thus be made available. The results of such myringoplasty in 15 ear cases, ranging in age from 21 to 75 years are presented in the following. The advantages of this treatment are summarized as follows;1) The operation can be done in an outpatient clinic.2) The surgical procedure is restricted to only the intrameatal region since obtaining the patients own temporal fascia is not necessary.3) Local anesthesia of the drum is sufficient for the operation.4) The patient may drink, eat, and return to work or school immediately following after surgery.5) The operation can be conducted on patients having general complications since general anesthesia is not required.However, the success rate of closure of the perforation was 67 per cent in this study. The reasons why the transplanted fascia was not “self” so to speak are considered. Attempts are being made to improve this rate such as by treatment of a homograft and application of fibronectin extracted from the patient's own serum to promote adherence of the graft.

著者

伊保 清子 浅野 和江 村山 真弓 阿久津 二夫 長沼 英明 徳増 厚二 岡本 牧人

出版者

一般社団法人 日本めまい平衡医学会

雑誌

Equilibrium Research (ISSN:03855716)

巻号頁・発行日

vol.70, no.2, pp.67-76, 2011 (Released:2011-06-01)

参考文献数

13

---

Appearance of the dominant peak-frequency in body sways during standing was retrospectively investigated in patients with spinocerebellar degeneration (SCD). Subjects tested were 25 patients with SCD (16 men and 9 women, ranging in age from 25 to 80; mean 55.8±15.4 yr). The disease types comprised SCA3 (n=5), SCA 6 (n=3), MSA-C (n=12), and an unknown type (n=5). Stabilometry was performed in each patient, who was asked to stand upright with a closed stance, with eyes open and eyes closed, using Anima's stabilometer G6100. The sampling time was 50 ms (20Hz) and the correcting time was 60 s. The peak-frequency was measured based on the power spectrum using the maximum entropy method (MEM). Total locus length, envelope area and velocity-vector of movement of the center of foot-pressure were also measured.The first or main peak appeared in a low frequency range between 0.10 and 0.59Hz in most of the cases with eyes open and eyes closed. It was detected in the lateral direction in 24 patients of the total number (96.0%) and in the anterior-posterior direction in 22 patients of the total (88.0%).The body sway of a frequency of 3Hz was detected in 4 patients (16.0%). Among them, the peak in the lateral direction was observed in 2 (8.0%) with eyes open or closed (one with SCA 6 and one with an unknown disease type). The peak in the anterior-posterior direction was detected in 3 (12.0%) with eyes open or closed (one each with SCA 6, MSA-C and an unknown disease type); in these subjects, the values of the total locus length divided by envelope area were more than 40.The dominant peak-frequency of 3Hz in body sways during standing did not frequently appear in patients with SCD, but it is suggested to be one of characteristic balance disorders in the disease.