- 著者
-
染井 正徳
- 出版者
- The Society of Synthetic Organic Chemistry, Japan
- 雑誌
- 有機合成化学協会誌 (ISSN:00379980)
- 巻号頁・発行日
- vol.40, no.5, pp.387-400, 1982-05-01 (Released:2009-11-13)
- 参考文献数
- 70
- 被引用文献数
-
11
15
Various new methods for the synthesis of 4-substituted indoles were developed. These involved a) three step synthesis of N-methyl-1, 3, 4, 5-tetrahydropyrrolo [4, 3, 2-de] isoquinolines, b) one step synthesis of 4-methylaminomethylindole, c) one pot sythesis of 4-hydroxymethylindole, d) the synthesis via 4-indolediazonium salts.Short step synthesis of ergot alkaloids, (±) -6, 7-secoagroclavine, was also achieved by 5 routes, utilizing such novel reactions as a) selective mono-alkylation of nitroalkanes with gramines, b) γ-alkylation of allyl alcohol with nitroalkanes, and c) reductive alkylation of nitroalkanes with Grignard reagents.