著者

水田 啓介 伊藤 八次 西田 基 秋田 茂樹 加藤 雅也 小塩 勝博 海田 健宏 古田 充哉 宮田 英雄 柳田 正巳 柴田 康成 横山 壽一 松原 茂規 小泉 光 森 芳郎 大野 通敏 近藤 由香 藤宮 大 山田 匡彦 渡辺 英彦 加藤 洋治

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.90, no.12, pp.1399-1407, 1997-12-01 (Released:2011-11-04)

参考文献数

14

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IPD® (supratast tosilate) was investigated for its prophylactic efficacy and therapeutic efficacy in the treatment of cedar pollinosis during the 1996 cedar pollen season. The subjects investigated were patients at the Gifu University School of Medicine and its affiliated hospitals, who had a history of cedar pollinosis. The patients were classified into two treatment groups: the prophylaxis group (70 patients), in whom IPD® administration began before the start of cedar pollen dispersion, and the treatment group (49 patients), who underwent IPD® treatment only after cedar pollen dispersion had begun and symptoms of pollinosis had manifested.Results were as follows: (1) The nasal symptoms (sneezing, runny nose, nasal congestion) were milder in the prophylaxis group than in the treatment group throughout the cedar pollen season, with the difference being significant during the season's first 2 weeks. (2) In the prophylaxis group, IPD®'s inhibitory effect was rated as excellent in 18.6% of the patients, good in 45.7% and fair in 20.0%. In the treatment group, the improvement in the symptoms was rated as disappearance in 4.2%, excellent in 20.8% and good in 43.8%. (3) When symptom inhibition in the prophylaxis group was investigated as a function of the duration of IPD® administration prior to the start of pollen dispersion, the good + excellent inhibition rate was 57.7% in the subpopulation pretreated for <2 weeks (26 cases), 64.9% with 2 to <4 weeks' pretreatment (37 cases) and 85.7% with 4 to <6 weeks' pretreatment (7 cases). Thus, IPD®'s prophylactic inhibitory rate increased with the length of the pretreatment period. (4) In the prophylaxis groups, the CAP-RAST value was significantly reduced at the time of peak pollen level and at the end of the pollen season compared with the value before IPD® administration.

著者

時田 喬 柴田 康成 小川 剛 宮田 英雄 大野 道敏

出版者

Japan Society for Equilibrium Research

雑誌

Equilibrium Research (ISSN:03855716)

巻号頁・発行日

vol.52, no.4, pp.602-610, 1993

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A new apparatus capable of recording head and eye movements was devised to examine the vestibulo-ocular system. Horizontal and vertical head movements were recorded with a sensor of terrestrial mgnetism. Eye movenments were recorded by an electronystagmographic technique. The transmitted data were stored on a floppy disc and analyzed with a microcomputer in a specially designed program.<BR>1. The apparatus was useful as a tool for recording spontaneous and gaze nystagmus and pursuit and saccadic eye movements in patients with labyrinthine and central disturbances.<BR>2. Transfer function (gain and phase) of the vestibulo-ocular system was calculated with head and eye movements obtained from pseudo-random head oscillation in the dark. In normal subjects, gain with head movements as input signal and eye movements as output signal indicated a frequency-dependent gain enhancement;the phase difference between head eye movements was 180°.<BR>3. The vestibulo-ocular reflex (VOR) induced by the right and left labyrinth were examined with velocity recording of head and eye movements induced by quick head movements to the right and left at intervals of 1 second in the dark. Patients with unilaterl labyrinthine disturbance showed a low amplitude response in head movements toward the affected labyrinth.<BR>4. The integration mechanism in the pursuit system was examined from the velocity recording of eye movements during vertical head oscillation with fixation on a visual target. A patient with primary position upbeat nystagmus caused by nutritional deficiency encephalopathy showed a disturbance of the up neural integrator from velocity signal to position signal in the visual vestibular oculomotor system.<BR>The apparatus was usuful for the examination of the vestibulo-ocular system of patients with vertigo and equilibrium disturbances.