著者

水田 啓介 伊藤 八次 西田 基 秋田 茂樹 加藤 雅也 小塩 勝博 海田 健宏 古田 充哉 宮田 英雄 柳田 正巳 柴田 康成 横山 壽一 松原 茂規 小泉 光 森 芳郎 大野 通敏 近藤 由香 藤宮 大 山田 匡彦 渡辺 英彦 加藤 洋治

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.90, no.12, pp.1399-1407, 1997-12-01 (Released:2011-11-04)

参考文献数

14

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IPD® (supratast tosilate) was investigated for its prophylactic efficacy and therapeutic efficacy in the treatment of cedar pollinosis during the 1996 cedar pollen season. The subjects investigated were patients at the Gifu University School of Medicine and its affiliated hospitals, who had a history of cedar pollinosis. The patients were classified into two treatment groups: the prophylaxis group (70 patients), in whom IPD® administration began before the start of cedar pollen dispersion, and the treatment group (49 patients), who underwent IPD® treatment only after cedar pollen dispersion had begun and symptoms of pollinosis had manifested.Results were as follows: (1) The nasal symptoms (sneezing, runny nose, nasal congestion) were milder in the prophylaxis group than in the treatment group throughout the cedar pollen season, with the difference being significant during the season's first 2 weeks. (2) In the prophylaxis group, IPD®'s inhibitory effect was rated as excellent in 18.6% of the patients, good in 45.7% and fair in 20.0%. In the treatment group, the improvement in the symptoms was rated as disappearance in 4.2%, excellent in 20.8% and good in 43.8%. (3) When symptom inhibition in the prophylaxis group was investigated as a function of the duration of IPD® administration prior to the start of pollen dispersion, the good + excellent inhibition rate was 57.7% in the subpopulation pretreated for <2 weeks (26 cases), 64.9% with 2 to <4 weeks' pretreatment (37 cases) and 85.7% with 4 to <6 weeks' pretreatment (7 cases). Thus, IPD®'s prophylactic inhibitory rate increased with the length of the pretreatment period. (4) In the prophylaxis groups, the CAP-RAST value was significantly reduced at the time of peak pollen level and at the end of the pollen season compared with the value before IPD® administration.

著者

時田 喬 宮田 英雄 青木 光広

出版者

一般社団法人 日本めまい平衡医学会

雑誌

Equilibrium Research (ISSN:03855716)

巻号頁・発行日

vol.72, no.4, pp.238-246, 2013-08-31 (Released:2013-10-01)

参考文献数

12

被引用文献数

2 1

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Frequency analysis of the sway of the body center of gravity appearing in the upright standing posture is important as one of the measurements in stabilometry. However, although analysis using the FFT method is now widely used, it is difficult to interpret the results. Therefore, using MEM method, we made a scatter diagram showing the frequency on the x-axis and the spectral peak area on the y-axis. In the scatter plot, we filled in the power law distribution curve and the approximate expression. This diagram (the peak-area spectrum) was the object of this study. The results obtained were as follows.1) In healthy cases, the area spectra showed the power law distribution. 2) In a case with labyrinthine failure, the spectrum showed an increase of the area of the maximum peak frequency. We considered the finding is caused by a disorder of the labyrinthine righting reflex. 3) In a case with cerebellum disturbance, irregularities were observed in the power law distribution of the peak areas. The findings are interpreted as due to a coordination disorder in standing posture regulation. 4) In a case of Parkinson's disease, the slope of the power law distribution curve became flat. The findings are interpreted as due to postural control disorder caused by muscle rigidity. Examination of the peak area spectrum is useful for quantitative assessment of the body sway in an upright standing posture.

著者

時田 喬 宮田 英雄 牧 達夫 浅井 徳光 橋本 正彦 前田 正徳 棚橋 聰子

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.73, no.6special, pp.1124-1130, 1980-06-25 (Released:2011-11-04)

参考文献数

4

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We report herein the examinations required for evaluation of the effects of treatment of Meniere's disease. Prior to the discussion, it is indispensable to clarify the design of the treatment. In the treatment, the authors take into consideration the following three subjects: (1) treatment of vertigo, (2) treatment of damage to the inner ear, and (3) treatment of recurrence of attacks of vertigo.(1) For evaluation of effects of treatment of vertigo in attacks and dizziness in the chronic stage of the disease, complaints of vertigo and spontaneous nystagmus as objective evidence of vertigo should be investigated. Furthermore, righting reflex and deviation test should be performed in order to demonstrate the mechanism of improvement of the vertigo. Despite the improvement obtained by inhibitory effects of drugs on the vertigo, the righting function and deviation phenomenon remain unchanged. On the contrary, when the pathological condition of the inner ear is healed there is an improvement of these signs.(2) Effects of the treatment for damage of the inner ear are evaluated by hearing and caloric tests. In cases where the labyrinthine excitability is not reversible, compensatory process of balancing activity of the body should be examined using the standing test, tests for spontaneous nystagmus, deviation and caloric tests and tests for postrotatory nystagmus. Disappearance of spontaneous nystagmus and deviation phenomenon reveal a recovery of static balance of the vestibular system. Disappearance of asymmetry of postrotatory nystagmus indicates a restoration of balance in the kinetic labyrinthine reflexes.(3) Recurrences of attacks of vertigo are treated on the basis of the results of examination of etiologic factors of Meniere's disease in each patient. Effects of this treatment should be evaluated by long-term follow-up of the vertiginous attacks.

著者

時田 喬 宮田 英雄 加藤 加藤 鈴木 省吾 小林 武

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.64, no.1, pp.3-15, 1971 (Released:2011-10-14)

参考文献数

22

著者

時田 喬 柴田 康成 小川 剛 宮田 英雄 大野 道敏

出版者

Japan Society for Equilibrium Research

雑誌

Equilibrium Research (ISSN:03855716)

巻号頁・発行日

vol.52, no.4, pp.602-610, 1993

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A new apparatus capable of recording head and eye movements was devised to examine the vestibulo-ocular system. Horizontal and vertical head movements were recorded with a sensor of terrestrial mgnetism. Eye movenments were recorded by an electronystagmographic technique. The transmitted data were stored on a floppy disc and analyzed with a microcomputer in a specially designed program.<BR>1. The apparatus was useful as a tool for recording spontaneous and gaze nystagmus and pursuit and saccadic eye movements in patients with labyrinthine and central disturbances.<BR>2. Transfer function (gain and phase) of the vestibulo-ocular system was calculated with head and eye movements obtained from pseudo-random head oscillation in the dark. In normal subjects, gain with head movements as input signal and eye movements as output signal indicated a frequency-dependent gain enhancement;the phase difference between head eye movements was 180°.<BR>3. The vestibulo-ocular reflex (VOR) induced by the right and left labyrinth were examined with velocity recording of head and eye movements induced by quick head movements to the right and left at intervals of 1 second in the dark. Patients with unilaterl labyrinthine disturbance showed a low amplitude response in head movements toward the affected labyrinth.<BR>4. The integration mechanism in the pursuit system was examined from the velocity recording of eye movements during vertical head oscillation with fixation on a visual target. A patient with primary position upbeat nystagmus caused by nutritional deficiency encephalopathy showed a disturbance of the up neural integrator from velocity signal to position signal in the visual vestibular oculomotor system.<BR>The apparatus was usuful for the examination of the vestibulo-ocular system of patients with vertigo and equilibrium disturbances.

著者

高木 恭也 村上 力夫 伊藤 八次 五島 桂子 松原 茂規 小島 俊己 宮田 英雄 時田 喬

出版者

一般社団法人 日本めまい平衡医学会

雑誌

Equilibrium Research (ISSN:03855716)

巻号頁・発行日

vol.49, no.2, pp.240-248, 1990 (Released:2009-10-13)

参考文献数

26

被引用文献数

2

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To clarify the peculiarities of gait disturbances in patients with labyrinthine, cerebellar and spinal disturbances, head movements and activity of the soleus muscles were studied during walking.The upward-downward (U-D), right-left (R-L) and forward-backward (F-B) movements of the head and activities of both soleus muscles were recorded by a polygraph with the aid of a five-channel telemeter. Head movements were recorded with three accelerometers attached to a helmet that the subject wore. Muscle activities was recorded by EMG with surface electrodes. At the same time the subject's foot-floor contact sequence was measured with electric switches in the shoes. These gait data were recorded on a pen oscillograph.1) In normal subjects, head movement recording revealed regular U-D movement and F-B inclination twice in each walking cycle and regular R-L inclination once in each walking cycle. Each soleus muscle was activated at the stance phase once in each walking cycle.2) A patient with unilateral labyrinthine disorder had head movements with irregular rhythm and ampulitude. L-R inclination of the head was not related to foot contact. The soleus muscle activities increased in the swing phase and decreased in the stance phase.3) A patient with bilateral loss of labyrinthine excitability had small, indistinct head movements with no relation to foot contact or foot raising. The record of the soleus muscle activities indicated plolongation of the active time and overlap of the activities of the two sides.4) A patient with spino-cerebellar degeneration had very irregular, unequal head movements, especially excessive F-B head movement. The active time of the soleus muscles was prolonged.5) A patient with left hemiparesis due to cervical myelopathy had small, irregular U-D and F-B head movements and large, sine wave like sway in R-Lhead movements. The soleus muscle activity of the left side in the stance phase was less than that of the right side. The record of the electric foot switch indicated that the subject often missed foot raising of her left leg.

著者

藤宮 大 熊田 貴彦 中村 好克 宮田 英雄 中島 茂 野澤 義則

出版者

一般社団法人 日本アレルギー学会

雑誌

アレルギー

巻号頁・発行日

vol.43, no.2, pp.142-151, 1994

被引用文献数

6

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ラット好塩基球性白血病(RBL-2H3)細胞を用いて, 抗原刺激による膜リン脂質代謝, カルシウム動態を検討し, 抗アレルギー薬TBX(ペミロラストカリウム)の作用機序の解明を試みた. 抗原刺激による分泌反応を, TBXは濃度依存的(0.01〜10μg/ml)に抑制した. また, TBXは分泌反応を抑制する同等の濃度で, セカンドメッセンジャーであるイノシトール1, 4, 5-トリスリン酸の産生とカルシウムの動員を抑えた. 従って, ホスホリパーゼC(PI-PLC)の活性化を抑制していることが示唆された. PI-PLC の活性化に続く, 主にホスファチジルコリンに由来する1, 2-ジアシルグリセロールとホスファチジン酸の産生も抑制された. さらに, エイコサノイドの前駆体であるアラキドン酸遊離を抑えることから, ホスホリパーゼA_2の活性化抑制も推測された. ホスファチジルコリンの分解, ホスホリパーゼA_2活性化は, イノシトールリン脂質代謝(PI-PLC活性化)が引き金となっていることから, PI-PLC活性化抑制がTBXの作用点として重要であると考えられる.