著者

松原 茂規 三鴨 廣繁 山岸 由佳

出版者

日本耳鼻咽喉科感染症・エアロゾル学会

雑誌

日本耳鼻咽喉科感染症・エアロゾル学会会誌 (ISSN:21880077)

巻号頁・発行日

vol.4, no.2, pp.107-115, 2016-05-20 (Released:2020-09-03)

参考文献数

10

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We report here that we could simultaneously detect many species of viruses (adenovirus, influenza virus, parainfluenza virus, rhinovirus, respiratory syncytial (RS) virus, bocavirus, metapneumovirus, coronavirus and enterovirus) among a total of 242 patients (121 males and 121 females; 4 of these patients were tested twice to make samples) with acute upper respiratory tract inflammation who visited our hospital between January 2015 and March 2015, by using RV 16 detection kit (AnyplexTM II RV16 detection kit, Seegene, South Korea) based on real-time PCR system. The mean age for these patients was 16.5 years, with a range of 4 months to 90 years. Nasopharyngeal samples from all of the patients were used for virus tests, and nasopharyngeal samples from patients suspected to have bacterial infection were used for bacteria tests. Virus speciemens were refrigerated and sent to Microbiological Laboratory, Department of Infection Control and Prevention, Aichi Medical University for analysis.Only viruses were detected in 153 patients (63%), viruses and bacteria were detected in 63 patients (26%), only bacteria were detected in 14 patients (6%), and neither viruses nor bacteria was detected in 12 patients (5%). The number of virus species detected per patient ranged from zero to six, 1.9 species on average. Adenovirus was the most frequently detected virus, followed by coronavirus, rhinovirus, metapneumovirus, and bocavirus. Adnovirus, coronavirus and influenza virus were commonly detected in January, metapneumovirus was frequently detected in February and March, and rhinovirus and bocavirus were common in March. Among the 242 patients, there were 18 patients with acute otitis media, 15 with exudative otitis media, 42 with acute rhinosinusitis and 14 with acute nasopharyngitis. Adnovirus, coronavirus, rhinovirus and metapneumovirus were often detected in patients with acute otitis media and those with exudative otitis media. In addition to these viruses, bocavirus was also frequently detected in patients with acute rhinosinusitis. Haemophilus influenzae or Moraxella catarrhalis and Adenovirus, rhinovirus, bocavirus, metapneumovirus, or coronavirus has been concurrently detected at a rate of 50% or more in patients with acute otitis media, exudative otitis media, acute rhinosisusitis and acute nasopharyngitis. Streptococcus pneumoniae and metapneumovirus or coronavirus has been concurrently detected in many cases.We consider that testing for detecting viruses causing upper respiratory tract infection will be useful for understanding the pathological condition of each patient, infection control in the community and detected causal microorganisms in patients with increasing severity of illness, if such testing is routinely performed in the future.

著者

水田 啓介 伊藤 八次 西田 基 秋田 茂樹 加藤 雅也 小塩 勝博 海田 健宏 古田 充哉 宮田 英雄 柳田 正巳 柴田 康成 横山 壽一 松原 茂規 小泉 光 森 芳郎 大野 通敏 近藤 由香 藤宮 大 山田 匡彦 渡辺 英彦 加藤 洋治

出版者

耳鼻咽喉科臨床学会

雑誌

耳鼻咽喉科臨床 (ISSN:00326313)

巻号頁・発行日

vol.90, no.12, pp.1399-1407, 1997-12-01 (Released:2011-11-04)

参考文献数

14

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IPD® (supratast tosilate) was investigated for its prophylactic efficacy and therapeutic efficacy in the treatment of cedar pollinosis during the 1996 cedar pollen season. The subjects investigated were patients at the Gifu University School of Medicine and its affiliated hospitals, who had a history of cedar pollinosis. The patients were classified into two treatment groups: the prophylaxis group (70 patients), in whom IPD® administration began before the start of cedar pollen dispersion, and the treatment group (49 patients), who underwent IPD® treatment only after cedar pollen dispersion had begun and symptoms of pollinosis had manifested.Results were as follows: (1) The nasal symptoms (sneezing, runny nose, nasal congestion) were milder in the prophylaxis group than in the treatment group throughout the cedar pollen season, with the difference being significant during the season's first 2 weeks. (2) In the prophylaxis group, IPD®'s inhibitory effect was rated as excellent in 18.6% of the patients, good in 45.7% and fair in 20.0%. In the treatment group, the improvement in the symptoms was rated as disappearance in 4.2%, excellent in 20.8% and good in 43.8%. (3) When symptom inhibition in the prophylaxis group was investigated as a function of the duration of IPD® administration prior to the start of pollen dispersion, the good + excellent inhibition rate was 57.7% in the subpopulation pretreated for <2 weeks (26 cases), 64.9% with 2 to <4 weeks' pretreatment (37 cases) and 85.7% with 4 to <6 weeks' pretreatment (7 cases). Thus, IPD®'s prophylactic inhibitory rate increased with the length of the pretreatment period. (4) In the prophylaxis groups, the CAP-RAST value was significantly reduced at the time of peak pollen level and at the end of the pollen season compared with the value before IPD® administration.

著者

松原 茂規

出版者

日本鼻科学会

雑誌

日本鼻科学会会誌 (ISSN:09109153)

巻号頁・発行日

vol.50, no.1, pp.56-57, 2011 (Released:2011-04-28)

著者

高木 恭也 村上 力夫 伊藤 八次 五島 桂子 松原 茂規 小島 俊己 宮田 英雄 時田 喬

出版者

一般社団法人 日本めまい平衡医学会

雑誌

Equilibrium Research (ISSN:03855716)

巻号頁・発行日

vol.49, no.2, pp.240-248, 1990 (Released:2009-10-13)

参考文献数

26

被引用文献数

2

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To clarify the peculiarities of gait disturbances in patients with labyrinthine, cerebellar and spinal disturbances, head movements and activity of the soleus muscles were studied during walking.The upward-downward (U-D), right-left (R-L) and forward-backward (F-B) movements of the head and activities of both soleus muscles were recorded by a polygraph with the aid of a five-channel telemeter. Head movements were recorded with three accelerometers attached to a helmet that the subject wore. Muscle activities was recorded by EMG with surface electrodes. At the same time the subject's foot-floor contact sequence was measured with electric switches in the shoes. These gait data were recorded on a pen oscillograph.1) In normal subjects, head movement recording revealed regular U-D movement and F-B inclination twice in each walking cycle and regular R-L inclination once in each walking cycle. Each soleus muscle was activated at the stance phase once in each walking cycle.2) A patient with unilateral labyrinthine disorder had head movements with irregular rhythm and ampulitude. L-R inclination of the head was not related to foot contact. The soleus muscle activities increased in the swing phase and decreased in the stance phase.3) A patient with bilateral loss of labyrinthine excitability had small, indistinct head movements with no relation to foot contact or foot raising. The record of the soleus muscle activities indicated plolongation of the active time and overlap of the activities of the two sides.4) A patient with spino-cerebellar degeneration had very irregular, unequal head movements, especially excessive F-B head movement. The active time of the soleus muscles was prolonged.5) A patient with left hemiparesis due to cervical myelopathy had small, irregular U-D and F-B head movements and large, sine wave like sway in R-Lhead movements. The soleus muscle activity of the left side in the stance phase was less than that of the right side. The record of the electric foot switch indicated that the subject often missed foot raising of her left leg.