著者
永井 一郎
出版者
一橋大学
雑誌
一橋論叢 (ISSN:00182818)
巻号頁・発行日
vol.69, no.1, pp.35-43, 1973-01-01

論文タイプ||論説
著者
高取 吉雄 永井 一郎
出版者
東京大学
雑誌
萌芽的研究
巻号頁・発行日
1999

昨年度の成果に基づき、筒型内固定体^<1)>および挿入器具^<2)>の改良を行なった。筒型内固定体のサイズは、外径19mm、内径15.5mmとし、筒体の長さは20mmと25mmの2種類を作製した。また、解剖用遺体での挿入実験から、挿入器具の柄はある程度長くないと、力を加えるハンドル部分が大腿内側に衝突することが明らかになった。このため、六角レンチなどの柄を長くし、300mmとした。これにより、比較的スムースに挿入できることがわかった。正確な挿入は、ガイドワイヤーを使用し、X線透視下で行なうことで可能と考えられた。註1)筒型内固定体この内固定材は、上下が開放した筒状の構造で、外壁にネジ山を有する形状とした。素材は生体親和性の高いチタンを選択した。使用に際しては、大腿骨頭の内下方から骨頭頂点を向けて挿入することを想定している。挿入された筒型内固定体は、罹患大腿骨頭内の頚部に近い側では、骨を筒の内部と外部に分断する。一方、関節面に近い部位では連続したままの状態である。大腿骨頭の中央に、壊死骨と健常骨の分界面が存在する場合には、内固定体の挿入により、壊死骨の形状は半球状から筒の内部の骨を加えた茸状に変化し、分界面の形状は単純な面ではなくなる。また壊死骨と健常骨とは筒型内固定体の外部のネジ山で固定される。この結果、大腿骨頭は、地滑り様の移動あるいは陥入を起こしにくくなると考えられる。2)挿入器具骨頭下リーマー、内固定体リーマー、タップ、六角レンチを試作した。この他、挿入手術用開創鉤、関節包用剪刀などについても試作した。
著者
浦上 貞治 寺尾 巌 永井 一郎
出版者
公益社団法人日本生物工学会
雑誌
醗酵工学会誌 : hakkokogaku kaishi (ISSN:03856151)
巻号頁・発行日
vol.64, no.2, pp.99-114, 1986-03-25

Production of single cell protein (SCP) by methanol-using bacteria was studied. A large number of methanol-using bacteria were isolated from a wide variety of natural sources in Japan. Strain BNK-84 was selected for its growth rate, growth temperature, cell yield, content of crude protein, and content of amino acids, and was identified as Methylobacillus glycogenes (Yordy and Weaver) emend. Urakami and Komagata 1986.Continuous cultures of this strain were done, and the feasibility of SCP production from methanol was studied. Optimum cultural condition were 38℃, pH 6.5-7.0,and a dilution rate of 0.2-0.6h^<-1>. Optimum dissolved oxygen (DO) was 1.5〜10ppm and optimum CO_2 partial pressure (PCO_2) was below 0.14atm. DO-limiting continous cultures were not suitable for the production of SCP because point of the cell yield. Methanol-limiting cultures showed the maximum specific growth rate, 0.60h^<-1>;the cell yield, 45 wt%;the content of crude protein, 86 wt%;the content of amino acids, 70 wt%;and the maximum content of nucleic acids, 20 wt%.For the commercial production of SCP, the continuous cultures with supernatant recycled, with high concentration of cells, and with long-term were studied. The continuous cultures with recycled supernatant were stable. At the feed methanol concentration of 16 wt%, the cell concentration was approximately 6 wt% and cell productivity reached approximately 15 g・l^<-1>・h^<-1>. Long-term continuous cultures (two hundred consecutive days) were stable with respect to the cell yield, the cell composition, and the stability of strain.Mitsubishi Gas Chemical Company (MGC) constructed a pilot plant, equiped with an air-lift fermentor with a nominal volume of 20 m_3,in 1974. Process engineering was done based on the data obtained from this pilot plant for the purpose of scale-up to a further commercial plant. Pilot plant operation was similar to the operation of a small jar fermentor. MGC developed sufficient know-how for the construction and operation of a commercial plant from the pilot plant operation.When SCP is used as the source of animal feed protein, two factors are most important, safety and nutritional value. The pathogenicity of strain BNK-84 was tested in laboratory animals, and it was confirmed to be nonpathogenic. The chemical composition of SCP indicated a high nutritional potential, and the amino acid composition was almost comparable with that of fish meal. Feeding trials of SCP using laying hens, broilers, and pigs were done in various institutes. The nutritional value of SCP was similar to that of soybeans.
著者
永井 一郎
出版者
社会経済史学会
雑誌
社會經濟史學 (ISSN:00380113)
巻号頁・発行日
vol.37, no.6, pp.602-629, 651-650, 1972-03-30

West Saxons made a landing at the south coast of Hampshire in 495. Then, conquering Britons, they went northward and reached the Upper Thames Valley in the second half of the six century. There they established West Saxon kingdom which included Hampshire, Wiltshire, and Berkshire. This is the story the Anglo-Saxon Chronicle tells us about the earliest history of Wessex. But according to archaeology and place name studies, it is evident that by the end of the fifth century a considerable number of Saxons had settled in the Upper Thames Valley. Moreover the Saxons who lived in Wiltshire and Hampshire in the fifth and sixth centuries were few and most of them were warriors. This discrepancy between the evidences about the Saxon settlement in the Upper Thames Valley can be explained that the Saxons in the Chronicle (Gewissae) conquered the Thames Saxons. In the laws of Ine we find "sixhynde", the lower class of nobles. This class is peculiar to the West Saxon kingdom and can not be found in other early laws of England. I take the view that "sixhynde" was the Thames Saxon obles whose amount of wergeld was lowered as the result of Gewissae's conquest. It is conjectured that Thames Saxon peasants began to migrate into Wiltshire in the first half of the seventh century at the earliest. There the native Britons hnd been under the rule of Gewissae for a long time, preserving their old settlement form, "vicus". The Saxon peasants were, in a sense, colonized among Britons without fights nor conquest, and they lived at peace with Britons. There was no general enslaving Britons under the Saxon peasants in Wiltshire.