1 0 0 0 OA 分岐鎖アミノ酸(BCAA)長期投与による肝細胞癌再発抑制
- 著者
- 土谷 薫 朝比奈 靖浩 泉 並木
- 出版者
- 一般財団法人 日本消化器病学会
- 雑誌
- 日本消化器病学会雑誌 (ISSN:04466586)
- 巻号頁・発行日
- vol.105, no.6, pp.808-816, 2008 (Released:2008-06-05)
- 参考文献数
- 38
- 被引用文献数
- 1
非代償性肝硬変患者において分岐鎖アミノ酸(BCAA)長期投与がイベント発生率(肝癌発生·静脈瘤破裂·肝不全の進行)を有意に低下させることは本邦からの大規模臨床試験で証明されている.今回われわれは肝癌根治治療後症例に対するBCAA長期投与の臨床的意義を検討し,特に初回治療前Alb 3.5g/dl以下の症例ではBCAA長期投与により有意に累積生存率が向上し3回目再発率が低下した結果を得た.今後はBTRやインスリン抵抗性(HOMA-IR)などさまざまな項目を検討し長期BCAA補充療法の適応症例について検討が必要である.
- 著者
- 桑原 道雄 泉 並木 三宅 祥三 陳 維嘉
- 出版者
- 一般社団法人 日本血液学会
- 雑誌
- 臨床血液 (ISSN:04851439)
- 巻号頁・発行日
- vol.22, no.6, pp.878-884, 1981 (Released:2009-01-26)
- 参考文献数
- 19
The patient was a 56-year-old man who had been exposed to the atomic bomb within 1km from the hypocenter when he was 22 years old in Hiroshima in 1945. After the expsure, general malaise and nausea were observed for three months. In 1970, non-Hodgkin's lymphoma (NHL) (diffuse, histiocytic) of the cervical lymph node (Stage I) occurred. Radical operation was performed and followed by the radiotherapy (6,000 rad, 200 KV X-ray) for five weeks. Thereafter, the patient had been asymptomatic and hematologically normal except that the radiotherapy (7,000 rad, cobalt-60) was delivered again for a right axillary mass lesion which occurred in 1975. In 1979, however, he was readmitted due to increasing general malaise and anemia. On admission, the hemoglobin was 5.9g/100ml, the platelet count 3.3×104/cmm, and leukocyte count 4,100/cmm with 6% blastoid cells and 43% monocytoid cells. The bone marrow aspirate yielded 39.8% blasts and 16.6% monocytoid cells, which were stained for both non-specific esterase (31%) and naphthol AS-D chloroacetate esterase (45%). Serum lysozyme was slightly elvated. From these data the diagnosis of acute myelomonocytic leukemia (AMMoL) was made.This is a very rare case of an atomic bomb survivor in whom NHL and AMMoL occurred 25 and 34 years later, respectively. On the genesis of these hemopoietic neoplasms, the influence of the exposure to the atomic bomb and/or radiation therapy are presumed.
