著者

穴見 江梨子 坂本 豊伸 磯尾 優子 德山 智治 塚本 賢児 興津 暁子 天方 奉子 稲葉 一郎 宮野 恭彰 木戸 宏幸 湯川 栄二

出版者

一般社団法人 日本医薬品情報学会

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.23, no.3, pp.135-142, 2021-11-30 (Released:2021-12-14)

参考文献数

14

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Objective: Soon after two massive earthquakes in Kumamoto, Japan, on April 14 and 16, 2016, the Shirakawasuigen pharmacy located in the Minamiaso village received prescriptions for disaster medications. Since prescriptions for disaster medications are typically used at temporary emergency shelters, pharmacies usually do not receive requests for them. On checking the content of these prescriptions, we found numerous prescription errors and queries. This study aimed to assess issues with dispensing medications after disasters.Methods: We reviewed all disaster medication prescriptions received by the pharmacy from April 20 to May 28, 2016 and the medication histories of these patients. We confirmed each patient’s data and medical and medication histories. Furthermore, we classified disaster prescription errors and queries into five categories according to their content and summed them in each category.Results: We obtained patients’ medical and medication histories from 100 (77.5%) of the 129 prescriptions received. Of the 129 prescriptions, a total of 158 prescription errors and queries pertaining to 96 (74.4%) prescriptions were confirmed: 88 (55.7%) for unclear medication usage and dosages, 22 (13.9%) for incorrect medication names, 34 (21.5%) for pharmaceutical queries, 8 (5.1%) for exceeding fixed prescription days (within seven days), and 6 (3.8%) for other issues.Conclusion: Nearly 80% of the prescriptions for disaster medications had prescription errors and queries. Therefore, we evaluated that the prescription’s format and entry method can be improved. Furthermore, to ensure a smooth drug supply and to reduce prescription entry deficiencies and formal prescription queries, pharmacists need to effectively manage disaster prescriptions.

著者

永崎 一樹 藤田 今日子 矢敷 潤 大串 彩 岡元 みなみ 河野 吉昭 田代 泰理 原田 将吾 福田 淳 水町 隆平 香月 信一郎 木戸 宏幸 湯川 栄二

出版者

第一薬科大学

雑誌

第一薬科大学研究年報 = Annual report of Daiichi University of Pharmacy (ISSN:02868016)

巻号頁・発行日

no.30, pp.27-36, 2014-03-31

著者

池田 浩人 森脇 英恵 松原 友規 湯川 美穂 岩瀬 由紀子 湯川 栄二 安藝 初美

出版者

公益社団法人 日本薬学会

雑誌

YAKUGAKU ZASSHI (ISSN:00316903)

巻号頁・発行日

vol.132, no.1, pp.145-153, 2012-01-01 (Released:2012-01-01)

参考文献数

8

被引用文献数

4 4

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The influence of the presence of a galloyl group in catechin on complexation with risperidone (RISP) was examined using (−)-epigallocatechin gallate (EGCg) and (−)-epigallocatechin (EGC), which are present in green tea as tea catechins. By quantitative analysis using HPLC, it was found that EGCg formed an insoluble complex with RISP for concentration dependence, whereas EGC did not. The large contribution of the galloyl group of catechin to form an insoluble complex with RISP was recognized in this study. In a molecular modeling study, it was found that the EGCg-R complex (EGCg with RISP) formed three hydrogen bonds between the hydroxyl groups of EGCg and the two N atoms and an O atom of RISP. The hydrogen bond between the hydroxyl group of the galloyl ring in EGCg and the N atom of the piperidine ring in RISP stabilized EGCg-R more energetically. The EGC-R complex (EGC with RISP) also formed three hydrogen bonds, but the N atom of the piperidine ring in RISP did not participate in hydrogen bond formation. According to the calculation using the COSMO-RS method, the water solubility of the EGCg-R complex was 1/26 that of the EGC-R complex. Therefore, the EGCg-R complex was difficult to dissolve in water. In the 1H-NMR spectra of RISP in DMSO-d6, although chemical shifts of protons near the N atom on the piperidine ring moved downfield on the addition of EGCg, no change in chemical shifts of these protons was observed on the addition of EGC. Therefore, based on these results, the galloyl group of EGCg contributes to the formation of an insoluble complex between tea catechin and RISP, and this insoluble complex is stabilized by the hydrogen bond between the hydroxyl group of the galloyl ring in EGCg and the N atom of the piperidine ring in RISP.

著者

大光 正男 Epp Denise A. 曲渕 直喜 湯川 栄二

出版者

第一薬科大学

雑誌

第一薬科大学研究年報 = Annual report of Daiichi University of Pharmacy (ISSN:02868016)

巻号頁・発行日

no.30, pp.59-72, 2014-03-31

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The Pharmaceutical Society of Japan proposed the "Model Core Curriculum for Pharmaceutical Education" to improve pharmaceutical education and to meet the changing health care needs in Japan. One of the basic concepts in the recent six-year Pharmacy Educational System is to enhance the current system to a level where Japanese pharmacists can participate more productively in the international arena. A practical command of English is necessary for the global exchange of data/information and dialog (journals, magazines, newspapers or direct contact) and a requirement stated in the Advanced Educational Guidelines. A global perspective and attitude from an educational perspective is also reflected in the current Model Core Curriculum of the six-year Pharmacy Educational System. This rapidly evolving need for greater internationalization of Medical Pharmacy and training of medical professionals who can play an active role globally in the area of International Scientific Exchange led to the development of an Overseas Pharmacy Training Course offered to first- through fifth-year students. The Daiichi University of Pharmacy Supporter's Association created study tours first to Northern Europe and then in March of 2013 to Canada, where there are high standards in pharmacy practice and collaborative drug therapy monitoring (CDTM) and an emphasis on the Continuing Education of a pharmacist with license updating. This paper summarizes the observations of the pharmacists' role and pharmacy education in the provinces of British Columbia and Alberta, as well as student participant responses from a questionnaire and small group discussions (SGD) following the study tour.

著者

末松 文博 湯川 栄二 峯本 正夫 湯川 美穂 大戸 茂弘 樋口 駿 後藤 良宣

出版者

一般社団法人日本医療薬学会

雑誌

医療薬学 (ISSN:1346342X)

巻号頁・発行日

vol.27, no.5, pp.426-431, 2001-10-10 (Released:2011-03-04)

参考文献数

18

被引用文献数

1 1

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The steady-state concentrations of digoxin at trough levels were studied to establish the role of infant characteristics in estimating the doses for digoxin based on routine therapeutic drug monitoring data. The data (n = 340) which showed a steady-state after repetitive oral administration in 147 hospitalized infants were analyzed using NONMEM, a computer program designed to analyze the pharmacokinetics in study populations by allowing for the pooling of data. An analysis of the pharmacokinetics of digoxin was accomplished using a simple steady-state pharmacokinetic model. The effects of a variety of developmental and demographic factors on the clearance of digoxin were investigated. Estimates generated using NONMEM indicated that the clearance of digoxin (L/hr/kg) was influenced by the demographic variables of age, the daily dose, serum creatinine, the presence or absence of congestive heart failure, and the coadministration of spironolactone in infants. The interindividual variability in the clearance of digoxin was modeled using proportional errors with an estimated coefficient of variation of 30.2%, while the residual variability was 28.2%.

著者

湯川 栄二

出版者

九州大学

巻号頁・発行日

1981

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博士論文

著者

湯川 美穂 池田 浩人 萩原 里美 黒田 菜月 川原 光喜 湯川 栄二 安藝 初美

出版者

公益社団法人 高分子学会

雑誌

高分子論文集 (ISSN:03862186)

巻号頁・発行日

vol.72, no.10, pp.648-651, 2015-10-25 (Released:2015-10-23)

参考文献数

12

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The mechanical properties of moderately dilute solution of Konjac powder (KP) and its hydrolysates (hKP) were characterized by viscosity and texture profile analysis. hKP was prepared by partial acid hydrolysis of KP in 70% ethanol solution at 130°C. The viscosities of 0.3%~0.5% KP solutions and 0.6%~1.0% hKP solutions were about 50~500 mPa·s and 80~400 mPa·s respectively. The hKP solution moved around the mouth more slowly and allowed better control of swallowing than KP solution. This indicates that hKP may be useful as a thickener to take medicine due to its low adhesiveness.