2 0 0 0 IR ヒマラヤ地域住民の生活習慣の調査と、心血管系機能の高所適応に見られる男女差
- 著者
- 大塚 邦明 Norboo Tsering 西村 芳子 山中 学 石川 元直 中島 俊 宝蔵 麗子 坂本 龍太 松林 公蔵 奥宮 清人
- 出版者
- 京都大学ヒマラヤ研究会・人間文化研究機構 総合地球環境学研究所「高所プロジェクト」
- 雑誌
- ヒマラヤ学誌 : Himalayan Study Monographs (ISSN:09148620)
- 巻号頁・発行日
- vol.11, pp.36-44, 2010-05-01
Aim: Numerous physiologic studies attempted to explain the effects of ambient hypoxia on humans, and now we know how humans adapted to it through changes in the expression of hypoxia-related genes. However, little is investigated about the gender difference from a view point of glocal (combined global and local) comprehensive assessment. Methods: We studied the effects of high altitude on pulse oximetry (SpO2), blood pressure (BP), heart rate (HR), aortic stiffness of cardio-ankle vascular index (CAVI). Subjects were 1, 858 Ladakhis (777 men and 1081 women). We investigated the gender difference of compensatory mechanisms by comparing the cardiovascular functions among 3 groups of high altitudes, i.e., from 2500 to 3000 m, from 3200 to 3720 m, and from 3800 to 4590m. Results: There observed no significant differences of the cardiovascular function among the three altitudes in men, but in women systolic BP became higher along with the altitudes and incidences of ECG findings, including 1st degree of AV block, ST depression and abnormal Q waves, became more frequent along with altitude. In addition, Ladakhi women showed steeper negative slope of the regression line between SpO2 and age, and larger slope of the regression line between systolic and diastolic BPs and age, compared with Ladakhi men. Conclusions: Our study indicates an existence of gender difference of adaptation to ambient hypoxia especially on cardiovascular functions, which suggests a need for the glocal comprehensive assessment for the better diagnosis and for the more fruitful treatment in community dwellers, especially at higher altitude.
1 0 0 0 OA 居住形態は入院中の高齢患者の抑うつに影響を与える
- 著者
- 磯谷 一枝 山中 学 石川 元直 扇澤 史子 望月 友香 稲葉 百合子 山本 直宗 山中 崇 大塚 邦明
- 出版者
- 一般社団法人 日本老年医学会
- 雑誌
- 日本老年医学会雑誌 (ISSN:03009173)
- 巻号頁・発行日
- vol.48, no.5, pp.570-571, 2011 (Released:2012-02-09)
- 参考文献数
- 5
- 被引用文献数
- 1 1
入院中の高齢者において抑うつは疾患治療を困難にする重要な問題であるが影響を与える因子については明らかではない.65歳以上の入院高齢患者174名を対象に,Geriatric depression scale(以下,GDS)を実施し,性別,年齢,基礎疾患,居住形態,認知機能との関連を検討したところ,患者の居住形態がGDSに最も強く独立して関連し独居群は家族同居群よりもGDSが高く治療意欲の低下を支持する回答が多く,独居高齢者では入院中に心理的援助がより必要である.