2 0 0 0 OA 神経ペプチドによる食欲・エネルギー代謝調節
- 著者
- 塩田 清二 竹ノ谷 文子 柴 加奈子 影山 晴秋
- 出版者
- 日本顎口腔機能学会
- 雑誌
- 日本顎口腔機能学会雑誌 (ISSN:13409085)
- 巻号頁・発行日
- vol.16, no.2, pp.85-92, 2010-02-28 (Released:2011-08-05)
- 参考文献数
- 27
新規Gタンパク質共役型受容体(GPCR)リガンドは脳内に広く分布し,摂食・エネルギー代謝調節を行っていることが知られている.本稿では,GPCRリガンドのうち最近発見された神経ペプチドに着目し,とくに摂食調節に関わる脳内神経ネットワーク解析の結果を報告する.これらペプチド性リガンドとしてオレキシン,グレリン,ガラニン様ペプチド,ニューロペプチドWなどについて視床下部におけるニューロンネットワークを概説し,摂食およびエネルギー代謝調節にどのように個々の神経ペプチドが関与しているかを解説し,末梢の脂肪細胞から分泌される摂食抑制物質であるレプチンとの関連性などについて概説する.これらの研究によって肥満を引き起こすメカニズムが解明できればヒトにおける肥満患者の抗肥満治療につながり,ひいては糖尿病や高血圧などの成人病の治療法の開発に有用である.
2 0 0 0 OA 体育系大学生を対象としたサプリメント摂取およびアンチ・ドーピングに対する意識調査
- 著者
- 堀内 正子 相良 篤信 吉田 梨紗 小林 百代 竹ノ谷 文子 琉子 友男 小林 哲郎 仲間 若菜 黄 仁官 里 史明 湯本 哲郎
- 出版者
- 一般社団法人日本医療薬学会
- 雑誌
- 医療薬学 (ISSN:1346342X)
- 巻号頁・発行日
- vol.47, no.12, pp.659-666, 2021-12-10 (Released:2022-12-10)
- 参考文献数
- 15
The number of people taking nutritional supplements has increased rapidly due to heightened health consciousness; however, cases of doping through supplement intake have also increased. Therefore, pharmacists need to share not only instructions related to medication, but also anti-doping (AD) directions for supplements with athletes. However, reports on the use of supplements in athletes are limited, and the actual situation is unknown. Then, we conducted a questionnaire survey on 1,249 physical education university students regarding the use of supplements and their awareness on doping. We also examined the steps that need to be taken by pharmacists to facilitate AD.We found that 60% of the respondents had taken supplements, 50% of whom (i.e., 30% of the total respondents) continued to do so. Furthermore, 40% took multiple supplements and were at risk of ‘inadvertent doping.’ Most of the respondents took supplements for improving muscle strength, fatigue recovery, and malnutrition. Furthermore, friends and seniors were often the triggers for supplement intake, suggesting that leaders and teams were also involved. Since many respondents purchased supplements at drug stores, it is important for pharmacists to educate athletes and their leaders about AD. Further, supplements, like pharmaceuticals, are constantly advancing and therefore pharmacists need to expand their knowledge and strive to expand their role.
2 0 0 0 OA ペプチドの点鼻投与と運動療法を用いた肥満解消の新戦略
- 著者
- 堀内 正子 相良 篤信 吉田 梨紗 小林 百代 竹ノ谷 文子 琉子 友男 小林 哲郎 仲間 若菜 黄 仁官 里 史明 湯本 哲郎
- 出版者
- 日本社会薬学会
- 雑誌
- 社会薬学 (ISSN:09110585)
- 巻号頁・発行日
- vol.40, no.1, pp.27-35, 2021-06-10 (Released:2021-06-29)
- 参考文献数
- 19
Introduction: Recently, doping among athletes has been on the rise, and pharmacists have an important role in both the promotion of anti-doping (AD) and in providing accurate information and effective support. In this study, we examined various fact-finding surveys that targeted physical education university (PEU) students, and we focused on their use of pharmacies/drugstores, their involvement with pharmacists, and knowledge about AD. We also examined the necessary AD-related professional competencies of pharmacists. Method: Questionnaire surveys were prepared, and the responses of 1,249 students were analyzed. Results : From a survey on what students buy at pharmacies/drug stores it showed that medicines for flu common colds sell the most. Most of the students did not receive any drug consultations at pharmacies/drug stores before purchasing, because they preferred to make their own decisions about drug use. Also, many students were wary of doping with supplements. Although the students who participated in international sports competitions and events possessed a wealth of doping-related knowledge and awareness, PEU students lacked them. Discussion : We determined that it was necessary to gather relevant patient information and explore methods so that intentions could be discussed when purchasing medications from pharmacies/drug stores. We also recognized the need for early doping education programs in light of the inadequate AD-related knowledge and awareness among university student-athletes. Therefore, all pharmacists should strive to acquire a wide range of knowledge to support athletes in this effort. Furthermore, we believe that expanding the professional functions of pharmacists would increase the awareness of AD among athletes.