著者

近藤 信一

出版者

公益社団法人 有機合成化学協会

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.49, no.9, pp.858-863, 1991-09-01 (Released:2009-11-16)

参考文献数

15

被引用文献数

1 1

著者

小川 和鋭 荒井 昌紀 長縄 博 池田 洋子 近藤 信一

出版者

The Japanese Society of Applied Glycoscience

雑誌

Journal of Applied Glycoscience (ISSN:13447882)

巻号頁・発行日

vol.48, no.4, pp.325-330, 2001-08-20 (Released:2011-02-23)

参考文献数

21

被引用文献数

11 13

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Chlorella vulgarisK22株(クロレラ工業)藻体より,中性多糖を得て,化学構造を検討した.部分酸加水分解法で,3種の新規な二糖,6-O-(3-O-methyl-β-D-galactopyranosyl)-D-galactopyranose,6-O-β-D-galactopyranosyl-3-O-methyl-D-galactopyranoseと6-O-(3-O-methyl--D-galactopyranosyl)-3-O-methyl-D-galactopyranose,およびβ-1,3-,β-1,6-結合のガラクトニ糖あるいは三糖を得たことから,この中性多糖は新規なβ-D-ガラクタンである.さらにこの中性多糖とその部分分解多糖のメチル化分析より,主鎖にβ-1,3-結合を,側鎖にβ-1,6-結合を含むこと,分岐領域にはβ-1,6-結合の3-O-メチル-D-ガラクトース残基をもつこと,また,側鎖の長さはこのモノメチル化糖を含めて14ガラクトース残基であることが示唆された.

著者

桜川 信男 湯浅 和典 近藤 信一 丹羽 正弘 横田 力

出版者

The Japanese Society on Thrombosis and Hemostasis

雑誌

血液と脈管 (ISSN:03869717)

巻号頁・発行日

vol.14, no.2, pp.228-230, 1983-06-01 (Released:2010-08-05)

参考文献数

5

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Crude drugs of Wakan-Yakus (traditional herbal drugs) such as Gaiyoh (Artemisiae folium), Sanshishi (Gardeniae fructus), Taiso (Zizyphi fructus), Kizutsu (Aurantii fructus immaturus) and Akyoh (Glutinum) were investigated to analyse the effects on blood coagulation system.(1) Gaiyoh (Artemisiae folium) showed the effects of anticoagulant, antifibrinolytic and anti-platelet aggregation, and the anticoagulant effect was strong prominently. When the crude drug of Gaiyoh was purified by the Sephadex G-100 column chromatography, four peaks were found. The strong antocoagulant effect was found to the third peak. We settled “Inhibition unit” of Gaiyoh from statistic studies, and 2.5mg/ml of Gaiyoh in the final concentration was evaluated to be 10 inhibition units.(2) Sanshishi (Gardeniae fructus) showed strong fibrinolytic effect characteristically.

著者

西村 吉雄 齋藤 仁 好川 博 近藤 信一 竹内 富雄

出版者

天然有機化合物討論会実行委員会

雑誌

天然有機化合物討論会講演要旨集 30 (ISSN:24331856)

巻号頁・発行日

pp.508-515, 1988-09-26 (Released:2017-08-18)

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The semi-synthetic podophyllotoxin glycosides, VP-16-213 (1) and VM-26 (2) showing a marked clinical efficacy and the intriguing mechanisms of action have stimulated interest in the synthesis of new active analogues of the podophyllotoxin glycoside. The systematic chemical modification of podophyllotoxins was studied. 1) Aminoglycosidic lignan variants (6, 7, etc.) of 4'-O-demethy1-1-epipodophyllotoxin were synthesized by a stereoselective BF_3-catalyzed coupling of 5 with the corresponding aminosugar derivatives. N-Alkylaminoglycosyl analogues (8, etc.) of 1 were also derived from 6. 2) Syntheses of all possible diastereomers (1, 6, 8, and 15-23) of 1, 6 and 8 were achieved via optical resolution of (±)-podophyllotoxin by glycosidation with D- and L-sugars. 3) Glycosidic variants of 1-β-hydroxy-α-peltatin and 1-β-hydroxy-8-O-methyl-a-peltatin (24-26) were synthesized by glycosidation of 28 and 29 with the corresponding sugar derivatives. 4) The syntheses of carbocyclic lignan variants (34-37) of 4'-O-demethyl-1-epipodophyllotoxin were achieved by coupling of 5 with chiral aminocyclitols. 5) 1-O-(2-Aminoethyl) ethers of 4'-O-demethyl-1-epipodophyllotoxin (38-42, etc.) were synthesized by coupling of 5 with the corresponding 2-aminoethanol derivatives, and with ethylene glycol followed by reductive amination of its aldehyde. Among all derivatives synthesized, 6 and 8 were found to have superior antitumor activity to 1.

著者

近藤 信一

出版者

産業学会

雑誌

産業学会研究年報 (ISSN:09187162)

巻号頁・発行日

vol.2017, no.32, pp.137-153, 2017 (Released:2018-04-01)

参考文献数

32

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In China, the IOT market has already been established in the consumer sector, and many Chinese companies have already entered the consumer IOT market. In this paper, the primary data collected in the local interview survey was sorted out using the PEST analysis of the external environmental analysis tool in the marketing strategy. I will introduce the “alliance”, “policy response” and “technology outflow” among the points of entering the market of Japanese companies that emerged based on PEST analysis. Business in China’s IOT market will be a different business model from business in global market. And China’s IOT market is policy driven and needs to pay attention to government trends.

著者

斉藤 仁 好川 博 西村 吉雄 近藤 信一 竹内 富雄 梅澤 濱夫

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.34, no.9, pp.3741-3746, 1986-09-25 (Released:2008-03-31)

参考文献数

11

被引用文献数

17 25

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D-(and L-)2, 6-Dideoxy-2-aminoglycosidic variants of 4'-O-demethyl-1-epipodophyllotoxin were synthesized by glycosidation of 4'-O-benzyloxycarbonyl- or 4'-O-chloroacetyl-4'-O-demethyl-1-epipodophyllotoxin (6 or 14) with the corresponding aminosugar derivatives. 1-O-(2-Amino-2-deoxy-4 : 6-O-ethylidene-β-D-glucopyranosyl)-4'-O-demethyl-1-epipodophyllotoxin (18) reacted with aldehydes in the presence of sodium cyanoborohydride, or reacted with α, β-unsaturated esters, or with α, β-unsaturated nitriles to yield the corresponding N-alkyl analogs. A number of the 4'-O-demethyl-1-epipodopyllotoxin β-D-aminoglycoside derivatives gave significant survival time increases in mice with leukemia L-1210. In particular, 1-O-(2-dimethylamino-2-deoxy-4 : 6-O-ethylidene-β-D-glucopyranosyl)-4'-O-demethyl-1-epipodophyllotoxin (19) showed superior activity to VP-16-213 (etoposide, 1).

著者

近藤信一 著

出版者

文求堂

巻号頁・発行日

1906

著者

斉藤 仁 好川 博 西村 吉雄 近藤 信一 竹内 富雄 梅澤 濱夫

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.34, no.9, pp.3733-3740, 1986-09-25 (Released:2008-03-31)

参考文献数

42

被引用文献数

8 14

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D-(and L-)Aminoglycosidic variants of 4'-O-demethyl-1-epipodophyllotoxin were synthesized by glycosidation of 4'-O-benzyloxycarbonyl- or 4'-O-chloroacetyl-4'-O-demethyl-1-epipodophyllotoxin (8 or 22) with the corresponding aminosugar derivatives. Cyclic acetals of 1-O-(2-amino-2-deoxy- and 3-amino-3-deoxy-β-D-glucopyranosyl)-4'-O-demethyl-1-epipodophyllotoxins (13 and 21) gave a significant survival time increase in mice with leukemia L-1210, and showed superior activity to VP-16-213 (etoposide, 5).

著者

近藤 信一 池田 大四郎

出版者

The Society of Synthetic Organic Chemistry, Japan

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.40, no.10, pp.902-911, 1982 (Released:2010-01-22)

参考文献数

79

被引用文献数

2 2

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Several 1, 4-diaminocyclitol-containing aminoglycoside antibiotics have been discovered by four Japanese research groups during the past five years. Fortimicin A, C, D and KG3 produced by Micromonospora, sporaricin A and C by Saccharopolyspora, istamycin A, B, C and A2, 2″- N-form-imidoylistamycin A and B by Streptomyces, and dactimicin by Dactylosporangium inhibit strongly the growth of Grampositive and -negative bacteria including most aminoglycosides-resistant strains. These antibiotics are pseudodisaccharides consisting of a diaminosugar and a 1, 4-diaminocyclitol acylated with glycine at the 4-methylamino group. Fortimicin A and some derivatives of this group antibiotics have been evaluated their clinical usefulness. In this review, chemical studies and structure-activty relationships of the 1, 4-diaminocyclitol-aminoglycoside antibiotics are discussed.

著者

近藤 信一

出版者

公益財団法人 日本感染症医薬品協会

雑誌

The Japanese Journal of Antibiotics (ISSN:03682781)

巻号頁・発行日

vol.47, no.6, pp.561-574, 1994-06-25 (Released:2013-05-17)

参考文献数

29

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アミノグリコシド抗生物質(AGs)の酵素学的耐性機構の研究と, それに基づく化学変換の研究によって合成したアルベカシン(ABK)は, ほとんどのAGs修飾酵素に安定で広範囲に優れた抗菌活性を示した。現在, メチシリン耐性黄色ブドウ球菌(MRSA)による肺炎と敗血症に限って臨床使用されている。僅かに分離されるABKに中等度耐性のMRSAによる不活性化の主体が, 2-OHの酵素的リン酸化であることを解明し, そのABKの2-OHをNH2に化学変換した誘導体と, さらにその5-OHを修飾した誘導体を種々合成し, 評価した。それらのうち, 2-Amino-5, 2-dideoxy-5-epiamino-ABKはABKより弱い腎毒性であったので, 低毒性の2-Amino-2-deoxy-ABKと共に抗MRSA薬として注目される化合物である。