著者

藤盛 真樹 鳥谷部 純行 角 伸博 嶋﨑 康相 宮澤 政義 宮手 浩樹 北田 秀昭 佐藤 雄治 三澤 肇 山下 徹郎 中嶋 頼俊 針谷 靖史 小林 一三 西方 聡 太子 芳仁 杉浦 千尋 笠原 和恵 浅香 雄一郎 榊原 典幸 岡田 益彦 柴山 尚大 末次 博 鈴木 豊典 阿部 貴洋 谷村 晶広 工藤 章裕 道念 正樹 川口 泰 野島 正寛 牧野 修治郎

出版者

公益社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.68, no.4, pp.168-183, 2022-04-20 (Released:2022-06-20)

参考文献数

38

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Tooth extraction is reported as the main trigger of bisphosphonate (BP) -related osteonecrosis of the jaw (BRONJ). A method to prevent BRONJ has not been scientifically proven. The American Association of Oral and Maxillofacial Surgeons (AAOMS) differs from the International Task Force on Osteonecrosis of the Jaw with regard to the prevention of BRONJ via prophylactic withdrawal before tooth extraction. We performed a multicenter prospective study regarding the development of BRONJ after tooth extraction in BP-treated patients for the purpose of determining factors associated with the frequency of BRONJ. We extracted teeth from patients with a history of current or prior treatment with BP preparations; teeth were extracted using a common treatment protocol. The presence or absence of BRONJ and adverse events were evaluated. A total of 1,323 cases were targeted for this study; 2,371 teeth were extracted. The overall incidence of BRONJ was 1.74%; in the prophylactic withdrawal group it was 1.73%, whereas in the prophylactic non-withdrawal group it was 1.75%. Factors associated with the onset of BRONJ were sex, preparation adaptation classification, oral hygiene state, site of tooth extraction, and Denosumab usage. From analysis that considered the effect of confounding using the propensity score, prophylactic BP withdrawal did not result in a reduction of BRONJ (onset odds ratio with withdrawal: 1.13, 95%CI 0.36-3.57).

著者

大井 一浩 井上 農夫男 金子 真梨 道念 正樹 松下 和裕 山口 博雄 戸塚 靖則

出版者

THE JAPANESE SOCIETY FOR JAW DEFORMITIES

雑誌

日本顎変形症学会雑誌 (ISSN:09167048)

巻号頁・発行日

vol.20, no.1, pp.1-7, 2010-04-15 (Released:2012-03-02)

参考文献数

26

被引用文献数

1

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The purpose of this study is to evaluate the incidence, risk factors and postoperative nausea and vomiting (PONV) in patients who underwent orthognathic surgery.The subjects were 139 patients aged 17-52 years (47 males and 92 females) who underwent orthognathic surgery in the Hokkaido University Hospital from January 2001 to December 2003. Ninety-four Sagittal splitting ramus osteotomy (SSRO), 34 Le Fort I osteotomy and SSRO (Le Fort I+SSRO), and 11 surgically assisted rapid palatal expansion (SARPE) were performed. Anesthesia was maintained with sevoflurane and nitrous oxide in oxygen. There were no cases of maxillomandibular fixation. The factors investigated included age, gender, type of surgery, amount of bleeding, operation time, anesthesia time, anesthesia induction drugs, fentanyl dose and incidence of PONV. A statistical study was performed using logistic regression analysis to confirm the statistical significance among age, gender, amount of bleeding, operation time, anesthesia time, difference of anesthesia induction drugs, fentanyl dose, and incidence of PONV. A Chi-square test for independence was used to confirm the statistical significance between the type of surgery and incidence of PONV. Differences were considered significant for a P<.05.Nausea was observed in 44.6% females and 17.1% males. The incidence of nausea was significantly higher in females. A significantly higher amount of vomiting was observed in 23.5% of Le Fort I+SSRO compared with 7.4% of SSRO and 9.1% of SARPE. Statistically significant differences for vomiting were also noted in the operation time and anesthesia time.