著者

藤盛 真樹 鳥谷部 純行 角 伸博 嶋﨑 康相 宮澤 政義 宮手 浩樹 北田 秀昭 佐藤 雄治 三澤 肇 山下 徹郎 中嶋 頼俊 針谷 靖史 小林 一三 西方 聡 太子 芳仁 杉浦 千尋 笠原 和恵 浅香 雄一郎 榊原 典幸 岡田 益彦 柴山 尚大 末次 博 鈴木 豊典 阿部 貴洋 谷村 晶広 工藤 章裕 道念 正樹 川口 泰 野島 正寛 牧野 修治郎

出版者

公益社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.68, no.4, pp.168-183, 2022-04-20 (Released:2022-06-20)

参考文献数

38

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Tooth extraction is reported as the main trigger of bisphosphonate (BP) -related osteonecrosis of the jaw (BRONJ). A method to prevent BRONJ has not been scientifically proven. The American Association of Oral and Maxillofacial Surgeons (AAOMS) differs from the International Task Force on Osteonecrosis of the Jaw with regard to the prevention of BRONJ via prophylactic withdrawal before tooth extraction. We performed a multicenter prospective study regarding the development of BRONJ after tooth extraction in BP-treated patients for the purpose of determining factors associated with the frequency of BRONJ. We extracted teeth from patients with a history of current or prior treatment with BP preparations; teeth were extracted using a common treatment protocol. The presence or absence of BRONJ and adverse events were evaluated. A total of 1,323 cases were targeted for this study; 2,371 teeth were extracted. The overall incidence of BRONJ was 1.74%; in the prophylactic withdrawal group it was 1.73%, whereas in the prophylactic non-withdrawal group it was 1.75%. Factors associated with the onset of BRONJ were sex, preparation adaptation classification, oral hygiene state, site of tooth extraction, and Denosumab usage. From analysis that considered the effect of confounding using the propensity score, prophylactic BP withdrawal did not result in a reduction of BRONJ (onset odds ratio with withdrawal: 1.13, 95%CI 0.36-3.57).

著者

牧野 修治郎

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.61, no.5, pp.261-261, 2015-05-20 (Released:2015-10-11)

著者

小村 健 武宮 三三 牧野 修治郎 嶋田 文之

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.39, no.4, pp.445-451, 1993-04-20 (Released:2011-07-25)

参考文献数

18

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Mandibular reconstruction remains one of the most challenging problems for the head and neck surgeon. Various methods of mandibular reconstruction have been described, including free bone grafts, osteomyocutaneous flaps, free vascularized bone grafts, reimplantation of treated mandibles, and reconstruction using alloplastic materials with particulate cancellous bone and marrow grafts.This paper describes the author's experience using a Dacron-urethane mandibular mesh tray filled with particulate cancellous bone and marrow for mandibular reconstruction.Six patients underwent resection of the mandible for malignant tumors, 7 for benign tumors, and 1 for radiation osteomyelitis.Immediate reconstruction was performed in 7 patients, and 5 of the 7 were successful. Delayed reconstruction was performed in another 7 patients, and 5 of the 7 were successful. The overall success rate was 71%. Mandibular reconstruction was successfully accomplished even following radiotherapy in 4 of 6 patients. The majority of the failures occurred in the first 10 days following surgery and the major factor in failure seemed to be related to intraoperative wound infection.The Dacron-urethane mandibular mesh tray has the advantage of being malleable but stiff, and can be easily cut with scissors to fit the defect. The tray is radiolucent, faciliting follow-up examinations by routine roentgenograms and radionuclide scans. It can be used either before or after radiotherapy.This reconstructive procedure is not technically difficult and does not require expertise in microvascular surgery. In selected patients, this procedure may significantly contribute to cosmetic and functional improvement following radical surgery of the mandible.

著者

小村 健 武宮 三三 牧野 修治郎 嶋田 文之

出版者

社団法人 日本口腔外科学会

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.38, no.4, pp.604-614, 1992-04-20 (Released:2011-07-25)

参考文献数

31

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A retrospective review of 6 patients with adenoid cystic carcinoma (ACC) of the submandibular gland treated between 1978 and 1991 was presented. Two patients who underwent aggressive surgery were disease-free, local control failed in 2 patients, and pulmonary metastasis developed in 2 patients without locoregional disease.This study supports the following conclusions:1. The perimeters of ACC are always more extensive than they appear to be clinically, because ACC has a strong tendency to invade the perineural space and extend for long distance.2. In preoperative diagnosis, aspiration cytology is essential for accurate diagnosis. Diagnostic imagings such as sialography, X-ray CT and MRI are helpful in detecting the size and extent of the tumor. RI study is indispensable in detecting the perineural spread3. Surgery is the treatment of choice, and it should be as extensive as possible, with a wide margin of healthy tissue. Radiation therapy, although not curative, plays an important role in prolonging survival and pain relief.4. ACC is characterized by slow growth, frequent recurrence, and systemic spread even after long-term survival without disease, therefore adjuvant chemotherapy should be taken into consideration.

著者

小村 健 牧野 修治郎 小野 貢伸 和田 重人

雑誌

日本口腔科学会雜誌 (ISSN:00290297)

巻号頁・発行日

vol.45, no.1, pp.72-79, 1996-01-10

被引用文献数

8

著者

小村 健 武宮 三三 牧野 修治郎 嶋田 文之

出版者

Japanese Society of Oral and Maxillofacial Surgeons

雑誌

日本口腔外科学会雑誌 (ISSN:00215163)

巻号頁・発行日

vol.38, no.4, pp.604-614, 1992

被引用文献数

2

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A retrospective review of 6 patients with adenoid cystic carcinoma (ACC) of the submandibular gland treated between 1978 and 1991 was presented. Two patients who underwent aggressive surgery were disease-free, local control failed in 2 patients, and pulmonary metastasis developed in 2 patients without locoregional disease.<BR>This study supports the following conclusions:<BR>1. The perimeters of ACC are always more extensive than they appear to be clinically, because ACC has a strong tendency to invade the perineural space and extend for long distance.<BR>2. In preoperative diagnosis, aspiration cytology is essential for accurate diagnosis. Diagnostic imagings such as sialography, X-ray CT and MRI are helpful in detecting the size and extent of the tumor. RI study is indispensable in detecting the perineural spread<BR>3. Surgery is the treatment of choice, and it should be as extensive as possible, with a wide margin of healthy tissue. Radiation therapy, although not curative, plays an important role in prolonging survival and pain relief.<BR>4. ACC is characterized by slow growth, frequent recurrence, and systemic spread even after long-term survival without disease, therefore adjuvant chemotherapy should be taken into consideration.